Early intervention of long-acting nifedipine GITS reduces brachial–ankle pulse wave velocity and improves arterial stiffness in Chinese patients with mild hypertension: a 24-week, single-arm, open-label, prospective study

Figures & data

Table 1 Baseline characteristics

Characteristic	Mean	ra	P-valuea
Age (years), mean ± standard deviation	48.43±11.92	0.069	0.232
Male, n (%)	71 (60.6)	0.122	0.098
BMI (kg/m^2), mean ± standard deviation	26.00±2.90	0.118	0.106
Smoking, n (%)	32 (31.6)	0.053	0.289
Alcohol consumption, n (%)	42 (35.89)	0.120	0.103
GLU (mmol/L), mean ± standard deviation	5.44±0.75	0.090	0.171
TG (mmol/L), mean ± standard deviation	1.88±1.00	0.004	0.482
CHOL (mmol/L), mean ± standard deviation	4.70±0.89	0.044	0.321
HDL (mmol/L), mean ± standard deviation	1.32±0.39	0.051	0.294
LDL (mmol/L), mean ± standard deviation	2.54±0.85	0.021	0.413

Note:

a n=117.

Abbreviations: BMI, body mass index; CHOL, cholesterol; HDL, high-density lipoprotein; LDL, low-density lipoprotein; TG, triglyceride; GLU, glucose.

Figure 1 Study flowchart.

Table 2 Changes in hemodynamic parameters and baPWV during the follow-up perioda

Variable	Baseline	4 weeks	12 weeks	24 weeks
SBP (mmHg)	153.56±11.75	135.85±10.10	134.08±8.52	134.04±9.93
DBP (mmHg)	94.65±9.54	84.94±7.59	83.85±7.90	83.39±9.31
PP (mmHg)	58.90±10.71	50.90±7.47	50.23±7.07	50.65±7.67
MAP (mmHg)	114.29±9.00	101.91±7.74	100.59±7.40	100.27±8.81
PWV (cm/s)	1,598.87±239.82	1,500.89±241.15	1,482.24±215.14	1,472.58±205.01
HR (bpm)	74.44±12.59	75.40±10.57	75.57±11.15	75.60±13.10
A-SBP (mmHg)	144.59±22.62	–	–	134.12±22.29
A-DBP (mmHg)	90.25±15.89	–	–	82.99±14.75

Notes:

a n=117. Data are presented as mean ± standard deviation.

Abbreviations: DBP, diastolic blood pressure; HR, heart rate; MAP, mean arterial pressure; SBP, systolic blood pressure; PP, pulse pressure; baPWV, brachial–ankle pulse wave velocity.

Figure 2 Correlation of baPWV with BP changes.

Abbreviations: baPWV, brachial–ankle pulse wave velocity; BP, blood pressure; SBP, systolic blood pressure; PWV, pulse wave velocity; MAP, mean arterial pressure; DBP, diastolic blood pressure; PP, pulse pressure.

Figure 3 Changes in hemodynamic parameters.

Abbreviations: BP, blood pressure; SBP, systolic blood pressure; MAP, mean arterial pressure; DBP, diastolic blood pressure; PP, pulse pressure.