Figures & data
Table 1 Dose-dependent effects of cisplatin on body, testicular, epididymis, seminal vesicle, prostate and kidney weights
Table 2 Dose-dependent effects of cisplatin on sperm count, motility, and apoptosis
Table 3 Dose-dependent effects of cisplatin on ROS/RNS and MDA in blood plasma
Table 4 Dose-dependent effects of cisplatin on RBC count, hemoglobin, and hematocrit
Figure 1 Effect of cisplatin on testosterone and testicular tissue.
Abbreviations: CIS-2, cisplatin 2 mg/kg i.p.; CIS-4, cisplatin 4 mg/kg i.p.; CIS-6, cisplatin 6 mg/kg i.p.; CIS-8, cisplatin 8 mg/kg i.p.; CIS-10, cisplatin 10 mg/kg i.p.; i.p., intraperitoneally; StAR, steroidogenic acute regulatory.
![Figure 1 Effect of cisplatin on testosterone and testicular tissue.](/cms/asset/8cbf0186-2bd5-4811-b4b8-5861da79b93d/dddt_a_12176271_f0001_b.jpg)
Figure 2 Effect of cisplatin on epididymal sperm.
Abbreviations: CIS-2, cisplatin 2 mg/kg i.p.; CIS-4, cisplatin 4 mg/kg i.p.; CIS-6, cisplatin 6 mg/kg i.p.; CIS-8, cisplatin 8 mg/kg i.p.; CIS-10, cisplatin 10 mg/kg i.p.; i.p., intraperitoneally.
![Figure 2 Effect of cisplatin on epididymal sperm.](/cms/asset/bef44da4-a589-4f75-92ef-1af51cd23e36/dddt_a_12176271_f0002_b.jpg)
Figure 3 Effect of cisplatin on endoplasmic reticulum stress markers.
Abbreviations: ATF, activating transcription factor; CIS-2, cisplatin 2 mg/kg i.p.; CIS-4, cisplatin 4 mg/kg i.p.; CIS-6, cisplatin 6 mg/kg i.p.; CIS-8, cisplatin 8 mg/kg i.p.; CIS-10, cisplatin 10 mg/kg i.p.; GRP-78, glucose-regulated protein-78; i.p., intraperitoneally; pIRE, phosphorylated inositol-requiring transmembrane kinase/endoribonuclease; pPERK, phosphorylated protein kinase RNA-like endoplasmic reticulum kinase.
![Figure 3 Effect of cisplatin on endoplasmic reticulum stress markers.](/cms/asset/ecbc567d-aa7c-4699-85ea-5bb1351d7c2b/dddt_a_12176271_f0003_b.jpg)
Table 5 Dose-dependent effects of cisplatin on renal index, BUN, and renal tubular necrosis
Figure 4 Light micrographs of tissue stained with hematoxylin and eosin (×400).
![Figure 4 Light micrographs of tissue stained with hematoxylin and eosin (×400).](/cms/asset/2b858519-17da-4f87-a6b2-54a1fe1bb274/dddt_a_12176271_f0004_c.jpg)
Table 6 Dose-dependent effects of cisplatin in spermatogenic cell density and Johnsen’s score of seminiferous tubules
Figure 5 Relation between cisplatin dose-dependent effect on ROS and ER stress.
![Figure 5 Relation between cisplatin dose-dependent effect on ROS and ER stress.](/cms/asset/472378fd-5ed2-4b68-993c-4bbeac7d59fa/dddt_a_12176271_f0005_c.jpg)