Figures & data
Figure 1 The canonical Wnt-β-catenin signaling pathway and the effects of inhibition through loss of function mutations and sclerostin inhibition.
Abbreviation: LRP, LDL-receptor-related protein.
![Figure 1 The canonical Wnt-β-catenin signaling pathway and the effects of inhibition through loss of function mutations and sclerostin inhibition.](/cms/asset/f012b3a8-e0ac-4640-a263-7042a5cafa53/dddt_a_127568_f0001_c.jpg)
Figure 2 Mechanism of action of romosozumab.
Abbreviation: LRP, LDL-receptor-related protein.
![Figure 2 Mechanism of action of romosozumab.](/cms/asset/8ead7790-3887-42dc-9a60-2099350d98cf/dddt_a_127568_f0002_c.jpg)
Table 1 Important Phase I, Phase II, and Phase III studies of romosozumab
Figure 3 Changes in the levels of bone formation markers and bone resorption markers with subcutaneous injections of TPTD (20 μg daily) or ROMO (210 mg once monthly) for 1 year.
Abbreviations: ROMO, romosozumab; TPTD, teriparatide.
![Figure 3 Changes in the levels of bone formation markers and bone resorption markers with subcutaneous injections of TPTD (20 μg daily) or ROMO (210 mg once monthly) for 1 year.](/cms/asset/b79deac1-174a-4371-89c2-42506fe70606/dddt_a_127568_f0003_c.jpg)