The modulation of enzyme indoleamine 2,3-dioxygenase from dendritic cells for the treatment of type 1 diabetes mellitus

Figures & data

Figure 1 Kynurenine and serotonin pathway.

Note: Tryptophan participates in serotonin and kynurenine pathways. Data from.^25,28–30

Figure 2 IDO and DC in the regulation of the T cell responses through the degradation of TRP and kynurenine metabolites.

Notes: (A) Depletion of TRP by IDO increases the metabolites of kynurenine and blocks T effector cell proliferation, favoring Treg differentiation. (B) Intracellular events in T effector cells in consequence of IDO activity in DCs.
Abbreviations: AHR, aryl hydrocarbon receptor; CTLA-4, cytotoxic T-lymphocyte-associated antigen 4; DCs, dendritic cells; HAA, 3-hydroxyanthranilic acid; IDO, indoleamine 2,3-dioxygenase; KRN, kynurenine; MHC, major histocompatibility complex; NF-kB, nuclear factor kappa B; PDK-1, phosphoinositide-dependent kinase 1; TCR, T cell receptor; Treg, T regulatory; TRP, tryptophan.

SugimotoHOdaSOtsukiTHinoTYoshidaTShiroYCrystal structure of human indoleamine 2,3-dioxygenase: catalytic mechanism of O2 incorporation by a heme-containing dioxygenaseProc Natl Acad Sci U S A20061038 2611 261616477023

 PubMed Web of Science ®Google Scholar

FatokunAHuntNHBallHJIndoleamine 2,3-dioxygenase 2 (IDO2) and the kynurenine pathway: characteristics and potential roles in health and diseaseAmino Acids2013456 1319 132924105077

 PubMed Web of Science ®Google Scholar

AllegriGCostaCVBertazzoABiasioloMRagazziEEnzyme activities of tryptophan metabolism along the kynurenine pathway in various species of animalsFarmaco2003589 829 83613679176

 PubMedGoogle Scholar