Determination of ED90s of Phenylephrine and Norepinephrine Infusion for Prevention of Spinal Anesthesia-Induced Hypotension in Patients with Preeclampsia During Cesarean Delivery

Figures & data

Figure 1 The Consolidated Standards of Reporting Trials flow diagram.

Table 1 Maternal Characteristics

	Phenylephrine Group (n=30)	Norepinephrine Group (n=30)	P value
Age, years	30.73 ± 6.20	31.17 ± 5.26	0.771
Body mass index, kg/m^2	31.19 ± 4.71	29.89 ± 4.11	0.260
Baseline systolic blood pressure, mmHg	149.27 ± 13.40	146.53 ± 13.62	0.437
Baseline diastolic blood pressure, mmHg	92.07 ± 10.27	93.00 ± 9.09	0.711
Baseline mean arterial pressure, mmHg	111.17 ± 10.25	110.83 ± 9.84	0.898
Baseline heart rate, bpm	86.03 ± 13.86	90.90 ± 14.13	0.183
Sensory block	T6 (T5 - T6)	T5 (T5 - T6)	0.181
Anesthesia to fetal delivery, min	14.60 ± 3.56	14.67 ± 2.62	0.934

Note: Values are mean ± SD or median (IQR).

Figure 2 The sequence number of responses to phenylephrine and norepinephrine infusion in the two groups of women with preeclampsia.

Figure 3 The dose-response curves and ED 90s (represented with the dotted lines) obtained from Probit regression analysis for both groups of women with preeclampsia in preventing spinal anesthesia-induced hypotension.

Table 2 Maternal and Neonatal Outcomes

	Phenylephrine Group (n=30)	Norepinephrine Group (n=30)	P value
Anesthesia induced-hypotension, n (%)	15 (50.0)	14 (46.67)	0.796
Bradycardia, n (%)	8 (26.67)	3 (10.0)	0.182
Hypertension, n (%)	2 (6.6)	1 (3.3)	0.550
Nausea or vomiting, n (%)	8 (26.67)	7 (23.3)	0.766
pH	7.31 ± 0.03	7.31 ± 0.03	0.308
Base excess (mmol/L)	−4.17 ± 1.51	−4.40 ± 1.42	0.535
Apgar score (1 min)	9 (8–9)	9 (8–9)	0.399
Apgar score (5 min)	10 (9–10)	9 (9–10)	0.800

Note: Values are n (%), mean ± SD or median (IQR).

Data Sharing Statement

The data that support the study findings are available from the corresponding author upon reasonable request.