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Drug Design, Development and Therapy Volume 10, 2016 - Issue
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Original Research

In vitro stress effect on degradation and drug release behaviors of basic fibroblast growth factor – poly(lactic-co-glycolic-acid) microsphere

Yan Xiong1 Department of Orthopedics, West China Hospital, Sichuan University, Chengdu, Sichuan, People’s Republic of China
,
Zeping Yu1 Department of Orthopedics, West China Hospital, Sichuan University, Chengdu, Sichuan, People’s Republic of China
,
Yun Lang1 Department of Orthopedics, West China Hospital, Sichuan University, Chengdu, Sichuan, People’s Republic of China
,
Juanyu Hu1 Department of Orthopedics, West China Hospital, Sichuan University, Chengdu, Sichuan, People’s Republic of China
,
Hong Li2 Laboratory of Biomechanical Engineering, Sichuan University, Chengdu, Sichuan, People’s Republic of China
,
Yonggang Yan2 Laboratory of Biomechanical Engineering, Sichuan University, Chengdu, Sichuan, People’s Republic of China
,
Chongqi Tu1 Department of Orthopedics, West China Hospital, Sichuan University, Chengdu, Sichuan, People’s Republic of China
,
Tianfu Yang1 Department of Orthopedics, West China Hospital, Sichuan University, Chengdu, Sichuan, People’s Republic of China
,
Yueming Song1 Department of Orthopedics, West China Hospital, Sichuan University, Chengdu, Sichuan, People’s Republic of China
,
Hong Duan1 Department of Orthopedics, West China Hospital, Sichuan University, Chengdu, Sichuan, People’s Republic of ChinaCorrespondence[email protected] [email protected]
&
Fuxing Pei1 Department of Orthopedics, West China Hospital, Sichuan University, Chengdu, Sichuan, People’s Republic of ChinaCorrespondence[email protected] [email protected]
 show all
Pages 431-440 | Published online: 25 Jan 2016

Figures & data

Figure 1 The morphology of bFGF-PLGA MS (observed by an FEI Quanta 200 scanning electron microscope; FEI, Hillsboro, OR, USA).

Note: Scale bar, 5 μm.
Abbreviation: bFGF-PLGA MS, basic fibroblast growth factor – poly(lactic-co-glycolic-acid) microsphere.
Figure 1 The morphology of bFGF-PLGA MS (observed by an FEI Quanta 200 scanning electron microscope; FEI, Hillsboro, OR, USA).

Figure 2 The equipment and experimental process of bFGF-PLGA MS degradation and drug release in static pressure loading experiment.

Abbreviation: bFGF-PLGA MS, basic fibroblast growth factor – poly(lactic-co-glycolic-acid) microsphere.
Figure 2 The equipment and experimental process of bFGF-PLGA MS degradation and drug release in static pressure loading experiment.

Figure 3 The shearing force load experiment equipment and experimental process of bFGF-PLGA MS degradation and drug release.

Notes: 1a closeup details the vertical section of the filter board on the left and the cross section of the filter board on the right.
Abbreviations: bFGF-PLGA MS, basic fibroblast growth factor – poly(lactic-co-glycolic-acid) microsphere; PBS, phosphate-buffered saline.
Figure 3 The shearing force load experiment equipment and experimental process of bFGF-PLGA MS degradation and drug release.

Figure 4 The scanning electron microscope images of bFGF-PLGA MS in shaking flask oscillation group.

Notes: (A) Before degradation. B–D are 2, 5, and 8 weeks after degradation, respectively. Scale bars, 5 μm for (A–D).
Abbreviation: bFGF-PLGA MS, basic fibroblast growth factor – poly(lactic-co-glycolic-acid) microsphere.
Figure 4 The scanning electron microscope images of bFGF-PLGA MS in shaking flask oscillation group.

Figure 5 The scanning electron microscope images of bFGF-PLGA MS in 4.0 pressure loading group.

Notes: (A, B) 5, 8 weeks after degradation. Scale bars, 5 μm for (A), 10 μm for (B).
Abbreviation: bFGF-PLGA MS, basic fibroblast growth factor – poly(lactic-co-glycolic-acid) microsphere.
Figure 5 The scanning electron microscope images of bFGF-PLGA MS in 4.0 pressure loading group.

Figure 6 The scanning electron microscope images of bFGF-PLGA MS in shearing force loading experiment group.

Notes: (A) Before degradation, (B) 3 weeks, (C) 5 weeks, and (D) 7 weeks after degradation. Scale bars 5 μm for (A, D), 10 μm for (B, C).
Abbreviation: bFGF-PLGA MS, basic fibroblast growth factor – poly(lactic-co-glycolic-acid) microsphere.
Figure 6 The scanning electron microscope images of bFGF-PLGA MS in shearing force loading experiment group.

Figure 7 The molecular weight changes of bFGF-PLGA MS during degradation in the static pressure loading experiment.

Note: The average of initial Mw was 11.32±0.11 kDa.
Abbreviations: bFGF-PLGA MS, basic fibroblast growth factor – poly(lactic-co-glycolic-acid) microsphere; Mw, molecular weight.
Figure 7 The molecular weight changes of bFGF-PLGA MS during degradation in the static pressure loading experiment.

Figure 8 The molecular weight changes of bFGF-PLGA MS during degradation in shearing force loading experiment.

Abbreviations: bFGF-PLGA MS, basic fibroblast growth factor – poly(lactic-co-glycolic-acid) microsphere; Mw, molecular weight.
Figure 8 The molecular weight changes of bFGF-PLGA MS during degradation in shearing force loading experiment.

Figure 9 Mass loss of bFGF-PLGA MS during degradation in the static pressure loading experiment.

Abbreviation: bFGF-PLGA MS, basic fibroblast growth factor – poly(lactic-co-glycolic-acid) microsphere.
Figure 9 Mass loss of bFGF-PLGA MS during degradation in the static pressure loading experiment.

Figure 10 Mass loss of bFGF-PLGA MS during degradation in shearing force loading experiment.

Abbreviation: bFGF-PLGA MS, basic fibroblast growth factor – poly(lactic-co-glycolic-acid) microsphere.
Figure 10 Mass loss of bFGF-PLGA MS during degradation in shearing force loading experiment.

Figure 11 Drug release of bFGF-PLGA MS during degradation in the static pressure loading experiment.

Abbreviation: bFGF-PLGA MS, basic fibroblast growth factor – poly(lactic-co-glycolic-acid) microsphere.
Figure 11 Drug release of bFGF-PLGA MS during degradation in the static pressure loading experiment.

Figure 12 Drug release of bFGF-PLGA MS during degradation in shearing force loading experiment.

Abbreviation: bFGF-PLGA MS, basic fibroblast growth factor – poly(lactic-co-glycolic-acid) microsphere.
Figure 12 Drug release of bFGF-PLGA MS during degradation in shearing force loading experiment.

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