Figures & data
Figure 2 SEM micrographs of the prepared liposomes of DNP.
Abbreviations: SEM, scanning electron microscopy; DNP, donepezil.
![Figure 2 SEM micrographs of the prepared liposomes of DNP.](/cms/asset/a6c93ed8-f30e-4f5b-9cb4-5e5b70747741/dddt_a_12177810_f0002_b.jpg)
Figure 3 In vitro release of DNP from liposomes (mean ± standard deviation, n=3).
![Figure 3 In vitro release of DNP from liposomes (mean ± standard deviation, n=3).](/cms/asset/41675e12-43bb-4e28-92b5-97336b46d680/dddt_a_12177810_f0003_c.jpg)
Table 1 Encapsulation efficiency and vesicle size of the prepared liposomes during storage at 4°C and 25°C over a period of 3 months
Table 2 Pharmacokinetic parameters of DNP in plasma post various routes of administration (mean ± SD, n=6)
Figure 4 Mean plasma concentration and time profile of donepezil with various routes of administration (mean ± standard deviation, n=6).
![Figure 4 Mean plasma concentration and time profile of donepezil with various routes of administration (mean ± standard deviation, n=6).](/cms/asset/50d303e3-fdcf-4e28-9f97-2e3de6b21cb4/dddt_a_12177810_f0004_c.jpg)
Table 3 Pharmacokinetic parameters of DNP in brain post various routes of administration (mean ± SD, n=6)
Figure 5 Mean brain concentrations and time profile of donepezil with various routes of administration (mean ± standard deviation, n=6).
![Figure 5 Mean brain concentrations and time profile of donepezil with various routes of administration (mean ± standard deviation, n=6).](/cms/asset/d058fff6-998e-4fde-8e84-494451739b8c/dddt_a_12177810_f0005_c.jpg)
Figure 6 Histopathological examinations of heart, lung, kidney, spleen, and liver.
![Figure 6 Histopathological examinations of heart, lung, kidney, spleen, and liver.](/cms/asset/a0090cf5-b007-4992-8f26-0ce0b1d18ed9/dddt_a_12177810_f0006_c.jpg)
Figure 7 Histopathological examinations of brain and olfactory bulb.
![Figure 7 Histopathological examinations of brain and olfactory bulb.](/cms/asset/dcfc8be6-caaa-42a6-ba6c-d5d880f8e639/dddt_a_12177810_f0007_c.jpg)
Table 4 Dissolution kinetic parameters for the DNP release from liposomal formulation