Fungistatic activity of all-trans retinoic acid against Aspergillus fumigatus and Candida albicans

Figures & data

Figure 1 Inhibitory effect of ATRA on Asperillus and Candida germination.

Notes: Resting Aspergillus fumigatus conidia or Candida albicans yeast cells were cultured in RPMI 1640 with 10% FCS at 37°C in the presence or absence of ATRA. (A) Conidia untreated, (B) conidia treated with ATRA 1 mM, (C) conidia treated with ATRA 0.5 mM, (D) Candida yeasts untreated, (E) Candida yeasts treated with ATRA 1 mM, (F) Candida yeasts treated with ATRA 0.5 mM, and (G) Candida yeasts treated with ATRA 0.25 mM. The germination of both fungi was followed using an optical microscope. Microscopic images were recorded after 8 and 4 hours of incubation for A. fumigatus conidia and C. albicans yeasts, respectively. Magnification: ×40.
Abbreviations: FCS, fetal calf serum; ATRA, all-trans retinoic acid.