Figures & data
Figure 1 Evidence of lincomycin breakdown products when 0.6 mg/mL lincomycin hydrochloride was prepared in 0.1 M HCl and stored at 60°C for 432 hours.
Notes: The lincomycin peak occurred at 11.719 minutes and the peak at 11.011 minutes is lincomycin B. The benzyl alcohol peak occurred at 17.945 minutes.
Table 1 Percentage of lincomycin hydrochloride retained (initial concentration 0.6 mg/mL) in four intravenous solutions stored at 25°C±0.1°C over 744 hours (31 days)
Table 2 Data for lincomycin showing the gradient of the first-order equations, coefficient of determination, first-order rate constant, and shelf-life values obtained at 80°C
Figure 2 Logk: pH profile of lincomycin 0.6 mg/mL as lincomycin hydrochloride at 80°C in selected buffers (I =0.5).
