Figures & data
Abbreviations: 5-ASA, 5-aminosalicylic acid; Ac-5-ASA, acetyl-5-aminosalicylic acid; SD, standard deviation.
Abbreviations: 5-ASA, 5-aminosalicylic acid; Ac-5-ASA, acetyl-5-aminosalicylic acid; AUCss, area under the curve for the defined interval between doses.
Notes: Numbers on the top left-hand corner of the boxes represent the compartment numbers for the population pharmacokinetic model in the NONMEM code. Hence, the two depot compartments were denoted as depot 1 and depot 3.
Abbreviations: ALAG1, absorption lag time from depot 1; 5-ASA, 5-aminosalicylic acid; Ac-5-ASA, acetyl-5-aminosalicylic acid; Ka1, absorption rate constant from depot 1; F1, fraction of dose absorbed from depot 1; Ka3, absorption rate constant from depot 3; ALAG3, absorption lag time from depot 3 in addition to the lag time from depot 1; CLM, metabolic clearance of 5-ASA; CLNRM, non-renal clearance of Ac-5-ASA; CLR, renal clearance of 5-ASA; CLRM, renal clearance of Ac-5-ASA.
Abbreviations: ALAG1, absorption lag time from depot 1; 5-ASA, 5-aminosalicylic acid; Ac-5-ASA, acetyl-5-aminosalicylic acid; Ka1, absorption rate constant from depot 1; F1, fraction of dose absorbed from depot 1; Ka3, absorption rate constant from depot 3; ALAG3, absorption lag time from depot 3 in addition to the lag time from depot 1; CLM, metabolic clearance of 5-ASA; CLNRM, non-renal clearance of Ac-5-ASA; CLR, renal clearance of 5-ASA; CLRM, renal clearance of Ac-5-ASA.
Notes: The dashed line represents the local regression (Loess) smoothing line. (A) Observed versus population predicted concentration; (B) observed versus individual predicted concentration; (C) conditional weighted residual versus population predicted concentration; (D) conditional weighted residual versus time.
Abbreviation: 5-ASA, 5-aminosalicylic acid.
Abbreviation: 5-ASA, 5-aminosalicylic acid.
Notes: The dashed line represents the local regression (Loess) smoothing line. (A) Observed versus population predicted concentration; (B) observed versus individual predicted concentration; (C) conditional weighted residual versus population predicted concentration; (D) conditional weighted residual versus time.
Abbreviation: Ac-5-ASA, acetyl-5-aminosalicylic acid.
Abbreviation: Ac-5-ASA, acetyl-5-aminosalicylic acid.