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Drug Design, Development and Therapy Volume 10, 2016 - Issue
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Review

Spotlight on tocilizumab and its potential in the treatment of systemic sclerosis

Lazaros I SakkasDepartment of Rheumatology and Clinical Immunology, Medical School, University of Thessaly, Larissa, GreeceCorrespondence[email protected]
Pages 2723-2728 | Published online: 29 Aug 2016

Figures & data

Figure 1 TCZ: mechanism of action.

Notes: IL-6 binds to tIL-6R (A) and sIL-6R (B), and this recruits two molecules of signal-transducing gp130 to activate cells. (C) TCZ binds to both tIL-6R and sIL-6R and blocks the action of IL-6.
Abbreviations: TCZ, tocilizumab; IL-6, interleukin-6; tIL-6R, transmembrane IL-6 receptor; sIL-6R, soluble IL-6 receptor; gp130, glycoprotein 130.
Figure 1 TCZ: mechanism of action.

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