A Vaccine Against Group B Streptococcus: Recent Advances

Figures & data

Table 1 Summary of Different Vaccine Candidates

Vaccine Candidate	Preclinical	Phase I	Phase II	Trials in Pregnant Women	Phase III
Monovalent and bivalent conjugates (tetanus toxoid/CRM197-CPS)	x	x	x	x
Trivalent CRM197-CPS conjugates	x	x	x	x
Hexavalent CRM197-CPS conjugates	x	x	x	x
N-terminal domains of the Rib and AlphaC proteins	x	x
Pilus proteins	x
Other proteins	x
Biotinylated CPS conjugates	x

Table 2 Alp Family Proteins Commonly Expressed in Different GBS Serotypes

GBS Serotype	Alp Family Protein Commonly Expressed
Ia	AlphaC, Alp1, Alp2
Ib	AlphaC
II	AlphaC, Rib
III	Rib, Alp2
V	Alp2, Alp3

Notes: This table includes only the Alp family proteins that are mostly expressed by the common serotypes causing infant GBS disease; The uncommon serotypes IV, VI–IX have not been included as their expression of proteins in the Alp family have not yet been characterized. Alp1 can also be referred to as Epsilon and Alp3 as R28.