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Infection and Drug Resistance Volume 13, 2020 - Issue
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Original Research

Combined Interventions for Severe Novel Coronavirus Disease (COVID-19): Experience from 350 Patients

Ting Guo1 Department of Respiratory and Critical Care Medicine, The Second Xiangya Hospital of Central-South University, Changsha, Hunan, People’s Republic of China;2 Research Unit of Respiratory Disease, Central-South University, Changsha, Hunan, People’s Republic of China;3 The Respiratory Disease Diagnosis and Treatment Center of Hunan Province, Changsha, Hunan, People’s Republic of China
,
Qinxue Shen1 Department of Respiratory and Critical Care Medicine, The Second Xiangya Hospital of Central-South University, Changsha, Hunan, People’s Republic of China;2 Research Unit of Respiratory Disease, Central-South University, Changsha, Hunan, People’s Republic of China;3 The Respiratory Disease Diagnosis and Treatment Center of Hunan Province, Changsha, Hunan, People’s Republic of China
,
Zhiguo Zhou4 Department of Respiratory and Critical Care Medicine, The First Hospital of Changsha, Changsha, Hunan, People’s Republic of China
,
Jinhua Li1 Department of Respiratory and Critical Care Medicine, The Second Xiangya Hospital of Central-South University, Changsha, Hunan, People’s Republic of China;2 Research Unit of Respiratory Disease, Central-South University, Changsha, Hunan, People’s Republic of China;3 The Respiratory Disease Diagnosis and Treatment Center of Hunan Province, Changsha, Hunan, People’s Republic of China
,
Wei Guo1 Department of Respiratory and Critical Care Medicine, The Second Xiangya Hospital of Central-South University, Changsha, Hunan, People’s Republic of China;2 Research Unit of Respiratory Disease, Central-South University, Changsha, Hunan, People’s Republic of China;3 The Respiratory Disease Diagnosis and Treatment Center of Hunan Province, Changsha, Hunan, People’s Republic of China
,
Wenlong He1 Department of Respiratory and Critical Care Medicine, The Second Xiangya Hospital of Central-South University, Changsha, Hunan, People’s Republic of China;2 Research Unit of Respiratory Disease, Central-South University, Changsha, Hunan, People’s Republic of China;3 The Respiratory Disease Diagnosis and Treatment Center of Hunan Province, Changsha, Hunan, People’s Republic of China
,
Yunnian Wang5 Department of Respiratory and Critical Care Medicine, The Traditional Chinese Medicine Hospital of Liling, Zhuzhou, Hunan, People’s Republic of China
,
Zhi Xiang6 Department of Respiratory and Critical Care Medicine, The First People’s Hospital of Huaihua, Huaihua, Hunan, People’s Republic of China
,
Peng Huang7 Department of Respiratory and Critical Care Medicine, The Central Hospital of Zhuzhou, Zhuzhou, Hunan, People’s Republic of China
,
Nanyang Zeng8 Department of Infectious Disease, The Lvkou People’s Hospital of Zhuzhou, Zhuzhou, Hunan, People’s Republic of China
,
Qingwu Qin1 Department of Respiratory and Critical Care Medicine, The Second Xiangya Hospital of Central-South University, Changsha, Hunan, People’s Republic of China;2 Research Unit of Respiratory Disease, Central-South University, Changsha, Hunan, People’s Republic of China;3 The Respiratory Disease Diagnosis and Treatment Center of Hunan Province, Changsha, Hunan, People’s Republic of China
,
Ping Chen1 Department of Respiratory and Critical Care Medicine, The Second Xiangya Hospital of Central-South University, Changsha, Hunan, People’s Republic of China;2 Research Unit of Respiratory Disease, Central-South University, Changsha, Hunan, People’s Republic of China;3 The Respiratory Disease Diagnosis and Treatment Center of Hunan Province, Changsha, Hunan, People’s Republic of China
,
Hong Luo1 Department of Respiratory and Critical Care Medicine, The Second Xiangya Hospital of Central-South University, Changsha, Hunan, People’s Republic of China;2 Research Unit of Respiratory Disease, Central-South University, Changsha, Hunan, People’s Republic of China;3 The Respiratory Disease Diagnosis and Treatment Center of Hunan Province, Changsha, Hunan, People’s Republic of ChinaORCID Iconhttps://orcid.org/0000-0002-9501-651X
ORCID Icon &
Hong Peng1 Department of Respiratory and Critical Care Medicine, The Second Xiangya Hospital of Central-South University, Changsha, Hunan, People’s Republic of China;2 Research Unit of Respiratory Disease, Central-South University, Changsha, Hunan, People’s Republic of China;3 The Respiratory Disease Diagnosis and Treatment Center of Hunan Province, Changsha, Hunan, People’s Republic of ChinaCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0003-3235-3348
ORCID Icon show all
Pages 3907-3918 | Published online: 30 Oct 2020

Figures & data

Table 1 Demographics and Baseline Characteristics of Patients with SARS-CoV-2 Infection

Figure 1 Flow chart summarizing the enrollment of COVID-19 patients.

Figure 1 Flow chart summarizing the enrollment of COVID-19 patients.

Figure 2 Age distributions of confirmed COVID-19 patients.

Figure 2 Age distributions of confirmed COVID-19 patients.

Table 2 Laboratory and Image Findings of Patients Infected with SARS-CoV-2 on Admission to Hospital

Figure 3 (A) CT images showed a ground-glass opacity (GGO) in the left pulmonary lobe of a 38-year-old female with mild symptoms on the first day of hospitalization, and follow-up images showed absorption on day 6. (B) CT images showed multiple mottling GGOs in a 63-year-old male with severe symptoms on the first day of admission, and follow-up images showed absorption on day 4.

Figure 3 (A) CT images showed a ground-glass opacity (GGO) in the left pulmonary lobe of a 38-year-old female with mild symptoms on the first day of hospitalization, and follow-up images showed absorption on day 6. (B) CT images showed multiple mottling GGOs in a 63-year-old male with severe symptoms on the first day of admission, and follow-up images showed absorption on day 4.

Table 3 Treatment and Outcomes of Patients Infected with SARS-CoV-2

Table 4 Risk Factors Associated with Severe COVID-19

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