Advanced search
Publication Cover
Infection and Drug Resistance Volume 13, 2020 - Issue
Submit an article Journal homepage
94
Views
2
CrossRef citations to date
0
Altmetric
Original Research

Combined Interventions for Severe Novel Coronavirus Disease (COVID-19): Experience from 350 Patients

Ting Guo1 Department of Respiratory and Critical Care Medicine, The Second Xiangya Hospital of Central-South University, Changsha, Hunan, People’s Republic of China;2 Research Unit of Respiratory Disease, Central-South University, Changsha, Hunan, People’s Republic of China;3 The Respiratory Disease Diagnosis and Treatment Center of Hunan Province, Changsha, Hunan, People’s Republic of China
,
Qinxue Shen1 Department of Respiratory and Critical Care Medicine, The Second Xiangya Hospital of Central-South University, Changsha, Hunan, People’s Republic of China;2 Research Unit of Respiratory Disease, Central-South University, Changsha, Hunan, People’s Republic of China;3 The Respiratory Disease Diagnosis and Treatment Center of Hunan Province, Changsha, Hunan, People’s Republic of China
,
Zhiguo Zhou4 Department of Respiratory and Critical Care Medicine, The First Hospital of Changsha, Changsha, Hunan, People’s Republic of China
,
Jinhua Li1 Department of Respiratory and Critical Care Medicine, The Second Xiangya Hospital of Central-South University, Changsha, Hunan, People’s Republic of China;2 Research Unit of Respiratory Disease, Central-South University, Changsha, Hunan, People’s Republic of China;3 The Respiratory Disease Diagnosis and Treatment Center of Hunan Province, Changsha, Hunan, People’s Republic of China
,
Wei Guo1 Department of Respiratory and Critical Care Medicine, The Second Xiangya Hospital of Central-South University, Changsha, Hunan, People’s Republic of China;2 Research Unit of Respiratory Disease, Central-South University, Changsha, Hunan, People’s Republic of China;3 The Respiratory Disease Diagnosis and Treatment Center of Hunan Province, Changsha, Hunan, People’s Republic of China
,
Wenlong He1 Department of Respiratory and Critical Care Medicine, The Second Xiangya Hospital of Central-South University, Changsha, Hunan, People’s Republic of China;2 Research Unit of Respiratory Disease, Central-South University, Changsha, Hunan, People’s Republic of China;3 The Respiratory Disease Diagnosis and Treatment Center of Hunan Province, Changsha, Hunan, People’s Republic of China
,
Yunnian Wang5 Department of Respiratory and Critical Care Medicine, The Traditional Chinese Medicine Hospital of Liling, Zhuzhou, Hunan, People’s Republic of China
,
Zhi Xiang6 Department of Respiratory and Critical Care Medicine, The First People’s Hospital of Huaihua, Huaihua, Hunan, People’s Republic of China
,
Peng Huang7 Department of Respiratory and Critical Care Medicine, The Central Hospital of Zhuzhou, Zhuzhou, Hunan, People’s Republic of China
,
Nanyang Zeng8 Department of Infectious Disease, The Lvkou People’s Hospital of Zhuzhou, Zhuzhou, Hunan, People’s Republic of China
,
Qingwu Qin1 Department of Respiratory and Critical Care Medicine, The Second Xiangya Hospital of Central-South University, Changsha, Hunan, People’s Republic of China;2 Research Unit of Respiratory Disease, Central-South University, Changsha, Hunan, People’s Republic of China;3 The Respiratory Disease Diagnosis and Treatment Center of Hunan Province, Changsha, Hunan, People’s Republic of China
,
Ping Chen1 Department of Respiratory and Critical Care Medicine, The Second Xiangya Hospital of Central-South University, Changsha, Hunan, People’s Republic of China;2 Research Unit of Respiratory Disease, Central-South University, Changsha, Hunan, People’s Republic of China;3 The Respiratory Disease Diagnosis and Treatment Center of Hunan Province, Changsha, Hunan, People’s Republic of China
,
Hong Luo1 Department of Respiratory and Critical Care Medicine, The Second Xiangya Hospital of Central-South University, Changsha, Hunan, People’s Republic of China;2 Research Unit of Respiratory Disease, Central-South University, Changsha, Hunan, People’s Republic of China;3 The Respiratory Disease Diagnosis and Treatment Center of Hunan Province, Changsha, Hunan, People’s Republic of ChinaORCID Iconhttps://orcid.org/0000-0002-9501-651X
ORCID Icon &
Hong Peng1 Department of Respiratory and Critical Care Medicine, The Second Xiangya Hospital of Central-South University, Changsha, Hunan, People’s Republic of China;2 Research Unit of Respiratory Disease, Central-South University, Changsha, Hunan, People’s Republic of China;3 The Respiratory Disease Diagnosis and Treatment Center of Hunan Province, Changsha, Hunan, People’s Republic of ChinaCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0003-3235-3348
ORCID Icon show all
Pages 3907-3918 | Published online: 30 Oct 2020

References

  • Na Z, Dingyu Z, Wenling W, et al. A novel coronavirus from patients with pneumonia in China, 2019. N Engl J Med. 2020;382(8):727–733. doi:10.1056/NEJMoa200101731978945
  • National Health Commission of the People’s Republic China. The latest situation of new coronavirus pneumonia. Available from: http://www.nhc.gov.cn/xcs/yqfkdt/202004/9631d3d14b514055ac74b9b4d1367904.shtml.
  • World Health Organization. WHO coronavirus disease (COVID-19) dashboard. Available from: https://covid19.who.int/.
  • World Health Organization. General’s opening remarks at the mission briefing on COVID-19-12; 2020 Available from: https://www.who.int/dg/speeches/detail/who-director-general-s-opening-remarks-at-the-mission-briefing-on-covid-19—12-march-2020.
  • Chaolin H, Yeming W, Xingwang L, et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet. 2020;395(10223):497–506. doi:10.1016/S0140-6736(20)30183-531986264
  • Dawei W, Bo H, Chang H, et al. Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected pneumonia in Wuhan, China. JAMA. 2020;e201585.
  • Nanshan C, Min Z, Xuan D, et al. Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study. Lancet. 2020;395(10223):507–513. doi:10.1016/S0140-6736(20)30211-732007143
  • Jinjin Z, Xiang D, Yiyuan C, et al. Clinical characteristics of 140 patients infected by SARS-CoV-2 in Wuhan, China. Allergy. 2020.
  • Sijia T, Nan H, Jing L, et al. Characteristics of COVID-19 infection in Beijing. J Infect. 2020;80(4):401–406.32112886
  • Xiao-Wei X, Xiao-Xin W, Xian-Gao J, et al. Clinical findings in a group of patients infected with the 2019 novel coronavirus (SARS-Cov-2) outside of Wuhan, China: retrospective case series. BMJ. 2020;368:m606.32075786
  • Jian W, Jun L, Xinguo Z, et al. Clinical characteristics of imported cases of COVID-19 in Jiangsu Province: a multicenter descriptive study. Clin Infect Dis. 2020;ciaa199.
  • Chinese National Health Committee. The diagnostic and treatment guideline for novel coronavirus pneumonia (version six). Available from: http://www.nhc.gov.cn/yzygj/s7653p/202002/8334a8326dd94d329df351d7da8aefc2.shtml.
  • Xiaolei L, Yang L, Junming L, et al. Immune characteristics distinguish patients with severe disease associated with SARS-CoV-2. Immunol Res. 2020;1–7.31970630
  • Chaochao T, Ying H, Fengxia S, et al. C‐reactive protein correlates with computed tomographic findings and predicts severe COVID‐19 early. J Med Virol. 2020;92(7):856–862. doi:10.1002/jmv.2587132281668
  • Aliye B, Hurrem B, Serpil E, et al. Clinical and laboratory features of COVID-19: predictors of severe prognosis. Int Immunopharmacol. 2020;88:106950.32919217
  • Edith S, Guillaume P, Violeta S, et al. Covid-19: contribution of clinical characteristics and laboratory features for early detection of patients with high risk of severe evolution. Acta Clin Belg. 2020;1–7.
  • Aining Z, Yan L, Yi Z, et al. Meta-analysis of coagulation parameters associated with disease severity and poor prognosis of COVID-19. Int J Infect Dis. 2020.
  • Wei Z, Zheng Z, Xingzhi X, et al. Relation between chest CT findings and clinical conditions of coronavirus disease (COVID-19) pneumonia: a multicenter study. AJR Am J Roentgenol. 2020;1–6.
  • Fei Z, Ting Y, Ronghui D, et al. Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study. Lancet. 2020;395(10229):1054–1062.32171076
  • Ling Q, Xie J, Zhifeng Q, et al. Aging of immune system: immune signature from peripheral blood lymphocyte subsets in 1068 healthy adults. Aging (Albany NY). 2016;8(5):848–859.26886066
  • Liu K, Chen Y, Lin R, Han K. Clinical features of COVID-19 in elderly patients: a comparison with young and middle-aged patients. J Infect. 2020.
  • Guan WJ, Liang WH, Zhao Y, et al. Comorbidity and its impact on 1590 patients with Covid-19 in China: a nationwide analysis. Eur Respir J. 2020;2000547.32217650
  • Simiao C, Zongjiu Z, Juntao Y, et al. Fangcang shelter hospitals: a novel concept for responding to public health emergencies. Lancet. 2020;S0140-6736(20)30744–3.
  • Grein J, Ohmagari N, Shin D, et al. Compassionate use of remdesivir for patients with severe covid-19. N Engl J Med. 2020;382(24):2327–2336. doi:10.1056/NEJMoa200701632275812
  • Chang C, Jianying H, Zhenshun C, et al. Favipiravir versus arbidol for COVID-19: a randomized clinical trial. medRxiv. 2020.
  • Gautret P, Lagier JC, Parola P, et al. Hydroxychloroquine and azithromycin as a treatment of COVID-19: results of an open-label non-randomized clinical trial. Int J Antimicrob Agents. 2020;56(1):105949. doi:10.1016/j.ijantimicag.2020.10594932205204
  • World Health Organization. Clinical management of severe acute respiratory infection when novel coronavirus (nCoV) infection is suspected: interim guidance; 2020 Available from: https://www.who.int/publications-detail/clinical-management-of-severe-acute-respiratory-infection-whennovel-coronavirus-(ncov)-infection-is-suspected.
  • Wu J, Li W, Shi X, et al. Early antiviral treatment contributes to alleviate the severity and improve the prognosis of patients with novel coronavirus disease (COVID-19). J Intern Med. 2020;288(1):128–138. doi:10.1111/joim.1306332220033
  • Lin L, Lianfeng L, Wei C, Taisheng L. Hypothesis for potential pathogenesis of SARS-CoV-2 infection-a review of immune changes in patients with viral pneumonia. Emerg Microbes Infect. 2020;9(1):727–732. doi:10.1080/22221751.2020.174619932196410
  • Jing L, Sumeng L, Jia L, et al. Longitudinal characteristics of lymphocyte responses and cytokine profiles in the peripheral blood of SARS-CoV-2 infected patients. medRxiv. 2020.
  • Russell CD, Millar JE, Baillie JK. Clinical evidence does not support corticosteroid treatment for 2019-nCoV lung injury. Lancet. 2020;395(10223):473–475. doi:10.1016/S0140-6736(20)30317-232043983
  • Xiaowei F, Qing M, Tianjun Y, et al. Low-dose corticosteroid therapy does not delay viral clearance in patients with COVID-1. J Infect. 2020.
  • Shang L, Jianping Z, Yi H, Ronghui D, Bin C. On the use of corticosteroids for 2019-nCoV pneumonia. Lancet. 2020;395(10225):683–684. doi:10.1016/S0140-6736(20)30361-532122468

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.