Serotype Distribution of Streptococcus pneumoniae Isolates Causing Invasive and Non-Invasive Infections Using Whole-Genome Sequencing in Ethiopia

Figures & data

Table 1 Distribution of S. pneumoniae Serotypes According to Source of Strain Isolation, Vaccination Status and Age Group at Addis Ababa and Amhara Region Referral Hospitals, Ethiopia, 2018–2019

Serotype/Serogroup(s)	Total No. (%) of Particular Serotype	% of Serotype by Source		% of Serotype by Vaccine Status		% of Serotype by Age Group
		Invasive	Non-Invasive	PCV10 Eligible Children	PCV10 Non-Eligible Patients	Children	Adults
15A/B/C^c	5 (8.8)	8.8	0.0	3.5	5.3	3.5	5.3
6A	4 (7.0)	7.0	0.0	1.8	5.2	3.5	3.5
10A/F^d	4 (7.0)	1.7	5.3	1.8	5.2	5.2	1.8
23A	4 (7.0)	0.0	7.0	0.0	7.0	3.5	3.5
7C	3 (5.3)	3.5	1.8	1.8	3.5	3.5	1.8
11A/B^e	3 (5.3)	1.8	3.5	0.0	5.5	1.8	3.5
13, 20, 21^a	3 (5.3)	0.0	5.3	0.0	5.5	0.0	5.3
35A/B^f	3 (5.3)	1.8	3.5	1.8	3.5	5.3	0.0
NT^b	3 (5.3)	3.5	1.8	5.3	0.0	5.3	0.0
8	2 (3.5)	3.5	0.0	0.0	3.5	1.8	1.8
14	2 (3.5)	3.5	0.0	1.8	1.8	1.8	1.8
16F	2 (3.5)	3.5	0.0	0.0	3.5	3.5	0.0
17F	2 (3.5)	0.0	3.5	1.8	1.8	1.8	1.8
19A	2 (3.5)	0.0	3.5	1.8	1.8	3.5	0.0
24, 29^a	2 (3.5)	1.8	1.8	3.5	0.0	3.5	0.0
1	2 (3.5)	3.5	0.0	0.0	3.5	1.8	1.8
3	2 (3.5)	3.5	0.0	3.5	0.0	3.5	0.0
38	2 (3.5)	1.8	1.8	0.0	3.5	3.5	0.0
45, 46^a	2 (3.5)	3.5	0.0	1.8	1.8	1.8	1.8
7F	1 (1.8)	1.8	0.0	0.0	1.8	1.8	0.0
18A	1 (1.8)	1.8	0.0	1.8	0.0	1.8	0.0
19F	1 (1.8)	1.8	0.0	0.0	1.8	0.0	1.8
23F	1 (1.8)	1.8	0.0	1.8	0.0	1.8	0.0
41F	1 (1.8)	0.0	1.8	1.8	0.0	1.8	0.0
Total No. (% of vaccinated children)	57 (35.1)	35 (40.0)	22 (27.3)	20 (100)	37 (0.0)	37 (54.1)	20 (0.0)
% of PCV10 vaccine coverage	12.3	20.0	0.0	10.0	13.5	10.8	15.0
% of PCV13 vaccine coverage	26.3	37.1	9.1	30.0	24.3	27.0	25.0

Notes: ^aExpected to serotypes/serogroups (strains were positive with one of the pooled sera only). ^bNon-typable strains. ^cSerogroup 15 included serotypes: 15A (= 1); 15B (= 3); and 15C (= 1). ^dSerogroup 10 included serotypes: 10A (= 3) and 10F (= 1). ^eSerogroup 11 included serotypes: 11A (= 1) and 11B (= 2). ^fSerogroup 35 included serotypes: 35A (= 1) and 35B (= 2).

Figure 1 Distribution of S. pneumoniae serotypes isolated from invasive pneumococcal diseases at Addis Ababa and Amhara Region Referral Hospitals, Ethiopia, 2018–2019.

Figure 2 Distribution of Streptococcus pneumoniae serotypes isolated from non-invasive pneumococcal diseases at Addis Ababa and Amhara Region Referral Hospitals, Ethiopia, 2018–2019.