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Original Research

Presence of HPV, EBV and HMTV Viruses Among Egyptian Breast Cancer Women: Molecular Detection and Clinical Relevance

ORCID Icon, ORCID Icon, , , , ORCID Icon, , , , ORCID Icon & ORCID Icon show all
Pages 2327-2339 | Published online: 23 Jun 2021

Figures & data

Table 1 Sequences of Primers Used for Human Papillomavirus (HPV), EpsteinBarr Virus (EBV) and Human Mammary Tumor Virus (HMTV) by Both Qualitative and Quantitative Polymerase Chain Reaction (PCR)

Table 2 Pathological Findings of Breast Cancer (BC) Patients

Table 3 HPV, EBV, and HMTV Frequency in FFPE Tissue and Fresh Tissue Samples of 80 BC Patients

Table 4 Agreement of Viral Detection Between Fresh Tissues and Corresponding WBCs of 40 BC Women

Figure 1 Detection of single and multiple HPV, EBV and HMTV infection among 40 BC fresh tissue samples. HPV/EBV/HMTV together found in 30%, followed by EBV/HMTV in 17.5%, HPV/HMTV in 10%, and HPV/EBV in 10%. HMTV DNA was the only virus present alone in 12.5% of BC fresh tissues.

Figure 1 Detection of single and multiple HPV, EBV and HMTV infection among 40 BC fresh tissue samples. HPV/EBV/HMTV together found in 30%, followed by EBV/HMTV in 17.5%, HPV/HMTV in 10%, and HPV/EBV in 10%. HMTV DNA was the only virus present alone in 12.5% of BC fresh tissues.

Figure 2 Detection of single and multiple HPV, EBV and HMTV infection among 40 BC WBCs samples. HPV/EBV/HMTV DNAs together were found in only 5%. The most frequent viruses present in co-infection were HPV/HMTV in 25% followed by EBV/HMTV in 2.5% and EBV/HPV in 2.5%. HMTV was the predominating single virus present in 25% followed by HPV in 7.5%.

Figure 2 Detection of single and multiple HPV, EBV and HMTV infection among 40 BC WBCs samples. HPV/EBV/HMTV DNAs together were found in only 5%. The most frequent viruses present in co-infection were HPV/HMTV in 25% followed by EBV/HMTV in 2.5% and EBV/HPV in 2.5%. HMTV was the predominating single virus present in 25% followed by HPV in 7.5%.

Table 5 Relation Between Presence of HPV, EBV or HMTV Qualitative PCR and Clinico-Pathological Findings of 40 BC Patients

Table 6 Relation Between Co-Existence of Viruses and Clinico-Pathological Findings of 40 BC Patients