Clonal Dissemination of Multiple Carbapenemase Genes in Carbapenem-Resistant Enterobacterales Mediated by Multiple Plasmids in China

Figures & data

Figure 1 Distribution of CRE isolates in the Hunan province and proportion of carbapenemase genes.

Table 1 Antimicrobial Susceptibility Rates of Clinical CRE Strains (MICs, mg/L)

Antimicrobial Agents	Number (%) of isolates
	R	S
Piperacillin	96.2	3.8
Cefoperazone-sulbactam	95.7	4.3
Piperacillin-tazobactam	94.7	5.3
Cefazolin	100.0	0
Cefatriaxone	98.5	1.5
Ceftazidime	98.0	2.0
Cefepime	98.2	1.8
Imipenem	98.7	1.3
Meropenem	97.7	2.3
Amikacin	46.1	53.9
Gentamicin	61.4	38.6
Ciprofloxacin	73.7	26.3
Levofloxacin	66.9	33.1
Trimethoprim- sulfamethoxazole	46.1	53.9
Tigecycline	6.0	94.0

Abbreviations: S, susceptible; R, resistant.

Figure 2 Distribution of carbapenemase among different CRE strains from adults and pediatric patients. The vertical axis represents the percent of each strain.

Figure 3 The bla_KPC-2-positive ST11 K. pneumoniae in Hunan province (part). Red and green squares indicate the presence or absence of the indicated resistance genes, respectively. Isolates with ≥90% genetic similarity were classified in the same group.

Abbreviations: Hos, hospital; G, Xiangya Hospital of Central South University; F, The First People’s Hospital of Xiangtan City; C, People’s Hospital of Ningxiang; D, The Third Hospital of Changsha; J, People’s Hospital of Shaoyang County; NA, not detected.

Figure 4 Clonal distribution of bla_IMP-38-positive ST307 K. pneumoniae and bla_NDM-1-positive ST2407 K. pneumoniae in Hunan Children’s Hospital. Red and green squares indicate the presence and absence of the indicated resistance genes, respectively.

Abbreviations: Hos, hospital; B, Hunan Children’s Hospital; Rt, replicon typing; NA, not detected.