Figures & data
Table 1 Demographic, Antimicrobial Susceptibility and Genotypic Data for the Clinical Isolates of P. aeruginosa Harboring OXA-10 Natural Variants
Figure 1 The genomic context of the blaOXA-677 (A), blaOXA-101 (B), blaOXA-246 (C). Genes are denoted by arrows. Genes, MGEs, and other features are colored based on their functional classification.
Figure 2 Amino acid alignment of OXA-10 and three OXA-10-like enzymes identified in this study. A dash indicates synonymous substitution without amino acid change. Key amino acid motifs conserved among OXA-10 are highlighted in red.
Figure 3 Superposition of OXA-10/OXA-101/ OXA-246 (blue), OXA-655 (yellow), and OXA-677 (red) with detailed view of active site. Leu155 and the omega loop are shown and labeled by the three mixed colors. Meropenem is depicted in green as a substrate. In the OXA-677 enzyme, the phenylalanine117 is closer to leucine155 in the omega loop.
Table 2 β-Lactam Resistance Profile Conferred by OXA-677 in E. coli DH5α Under Isogenic Conditions