Detection of NDM-1-Positive Aeromonas caviae from Bacteremia by Using Whole-Genome Sequencing

Figures & data

Table 1 Antimicrobial Susceptibility Profiles of NDM-Producing Aeromonas caviae of Isolates

Isolate	MIC (mg/L)^a
	AMC	TZP	CAZ	CRO	CPM	ETP	IPM	AMK	LVX	TGC	SXT
HZ574	32	128	64	64	16	8	16	2	8	8	20
HZ578	32	128	32	64	16	8	8	2	8	4	20

Notes: ^aMICs were determined by VITEK 2 system with AST-GN16 panel.

Abbreviations: AMC, amoxicillin/clavulanic acid; TZP, piperacillin/tazobactam; CAZ, ceftazidime; CRO, ceftriaxone; CPM, cefepime; ETP, ertapenem; IPM, imipenem; AMK, amikacin; LVX, levofloxacin; TE, tetracycline; TGC, tigecycline, SXT, trimethoprim/sulfamethoxazole.

Figure 1 Construction of phylogenetic trees of A. caviae. The figure includes the sample source of the isolate, MLST, antibiotic resistance gene, and the comparison result of the virulence gene.

Figure 2 S1 Nuclease-pulsed field gel electrophoresis (S1-PFGE) and southern blot. The number and size of the plasmid of the two isolates were characterized by the S1 Nuclease-pulsed field gel electrophoresis (S1-PFGE).

Figure 3 The genetic environment of the bla_NDM-1 gene in A. caviae was isolated from clinical sources. The arrows represent the direction of transcription. The red open reading frame (ORF) indicates the bla_NDM-1 gene, the yellow ORF indicates the mobile element, the green ORF indicates enzymes, and the grey ORF indicates other genes or genes of unknown function.