Recent Advances of Circular RNAs as Biomarkers for Osteosarcoma

Figures & data

Figure 1 Function of circular RNA; potential application of circular RNA in the diagnosis and treatment of osteosarcoma.

Table 1 Expression and Association of CircRNAs in Osteosarcoma

CircRNA	Dysregulation	Functions/Mechanisms	Genes/Proteins Affected	Signaling Pathway	(Refs.)
CircTCF25	Up	Promotes the proliferation, migration, and invasion	Upregulation: cyclinD1/CDK6/MMP2/MMP9/vimentin; down-regulation: miR-206/TIMI-1	MEK/ERK, AKT/mTOR	[21]
CircMMP9	Up	Higher viability, colony-forming ability, migration and invasion ability, TMN stage, the lower overall survival rate	Upregulation: CHI3L1; down-regulation: miR-1265	circMMP9/miR-1265/CHI3L1	[23]
Circ001621	Up	Promotes the proliferation and migration, higher TNM stage, shorter overall survival	Upregulation: VEGF/CDK4/MMP9; down-regulation: miR-578	mir-578/VEGF	[25]
Circ0001658	Up	Promotes the proliferation, migration, and invasion, hinder apoptosis	Upregulation: YB-1; down-regulation: mir-382-5p	circ0001658/miR-382-5p/YB-1	[26]
CircEPSTI1	Up	Cell proliferation and migration	Upregulation: MCL1; down-regulation: miR-892b	circEPSTI1-miR-892b- MCL1	[27]
CircANKIB1	Up	Cell proliferation, invasion, and inhibit apoptosis	Upregulation: miR-19b; down-regulation: SOCS3	circANKIB1/miR-19b/SOCS3	[28]
Circ-LARP4	Down	Decreased Enneking stage, prolonged survival profiles, and elevated chemosensitivity to cisplatin and doxorubicin	Downregulation: mir-424	_	[29]
Circ0002052	Down	Suppresses proliferation, migration and invasion while promoting apoptosis	Upregulation: APC2; down-regulation: miR-1205	circ0002052/miR-1205/APC2/Wnt/b-catenin	[30]
CircROCK1-E3/E4	Down	Suppresses proliferation and migration ability	Upregulation: PTEN; down-regulation: miR-532-5p	circROCK1-E3/E4/miR-532-5p/PTEN	[31]
CircNRIP1	Down	Suppresses migration, invasion and proliferation	Upregulation: MIA2; down-regulation: miR-1200	circNRIP1/miR-1200/MIA2	[32]
CircITCH (multifunctional)	Up	Promotes the migration, invasion, and growth	Upregulation: EGFR; down-regulation: miR-7	circITCH /miR-7/EGFR	[36]
	Down	Suppresses cell growth, migration, and invasion capacity promotes apoptosis	Upregulation: PTEN; down-regulation: miR-22	PTEN/PI3K/AKT and SP-1	[37]

Wang Y, Shi S, Zhang Q, Dong H, Zhang J. MicroRNA-206 upregulation relieves circTCF25-induced osteosarcoma cell proliferation and migration. J Cell Physiol. 2020;2020:114.

 Google Scholar

Pan G, Hu T, Chen X, Zhang C. Upregulation of circMMP9 promotes osteosarcoma progression via targeting miR-1265/CHI3L1 axis. Cancer Manag Res. 2019;11:9225–9231. doi:10.2147/CMAR.S226264

 PubMed Web of Science ®Google Scholar

Ji X, Shan L, Shen P, He M. Circular RNA circ_001621 promotes osteosarcoma cells proliferation and migration by sponging miR-578 and regulating VEGF expression. Cell Death Dis. 2020;11(1):18. doi:10.1038/s41419-019-2204-y

 PubMed Web of Science ®Google Scholar

Wang L, Wang P, Su X, Zhao B. Circ_0001658 promotes the proliferation and metastasis of osteosarcoma cells via regulating miR-382-5p/YB-1 axis. Cell Biochem Funct. 2020;38(1):77–86. doi:10.1002/cbf.3452

 PubMed Web of Science ®Google Scholar

Tan X, Tan D, Li H, Lin Y, Wen Z, Zeng C. circEPSTI1 acts as a ceRNA to regulate the progression of osteosarcoma. Curr Cancer Drug Targets. 2020;20(4):288–294. doi:10.2174/1568009619666191107140948

 PubMed Web of Science ®Google Scholar

Du Y, Guo L, Pan H, Liang Y, Li X. Circ_ANKIB1 stabilizes the regulation of miR-19b on SOCS3/STAT3 pathway to promote osteosarcoma cell growth and invasion. Hum Cell. 2020;33(1):252–260. doi:10.1007/s13577-019-00298-6

 PubMed Web of Science ®Google Scholar

Hu Y, Gu J, Shen H, et al. Circular RNA LARP4 correlates with decreased Enneking stage, better histological response, and prolonged survival profiles, and it elevates chemosensitivity to cisplatin and doxorubicin via sponging microRNA-424 in osteosarcoma. J Clin Lab Anal. 2020;34(2):e23045. doi:10.1002/jcla.23045

 PubMed Web of Science ®Google Scholar

Wu Z, Shi W, Jiang C. Overexpressing circular RNA hsa_circ_0002052 impairs osteosarcoma progression via inhibiting Wnt/β-catenin pathway by regulating miR-1205/APC2 axis. Biochem Biophys Res Commun. 2018;502(4):465–471. doi:10.1016/j.bbrc.2018.05.184

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Liu Y, Qiu G, Luo Y, et al. Circular RNA ROCK1, a novel circRNA, suppresses osteosarcoma proliferation and migration via altering the miR-532-5p/PTEN axis. Exp Mol Med. 2022;54(7):1024–1037. doi:10.1038/s12276-022-00806-z

 PubMed Web of Science ®Google Scholar

Hei R, Chen J, Zhang X, et al. CircNRIP1 acts as a sponge of miR-1200 to suppress osteosarcoma progression via upregulation of MIA2. Am J Cancer Res. 2022;12(6):2833–2849.

 PubMed Web of Science ®Google Scholar

Li H, Lan M, Liao X, Tang Z, Yang C. cir-ITCHCircular RNA promotes osteosarcoma migration and invasion through /miR-7/EGFR pathway. Technol Cancer Res Treat. 2020;19:1533033819898728.

 Web of Science ®Google Scholar

Ren C, Liu J, Zheng B, Yan P, Sun Y, Yue B. The circular RNA circ-ITCH acts as a tumour suppressor in osteosarcoma via regulating miR-22. Artif Cells. 2019;47(1):3359–3367. doi:10.1080/21691401.2019.1649273

 PubMed Web of Science ®Google Scholar