The Relationship Between the Expression of CRBN in Peripheral Blood and the Severity and Prognosis of Adult Sepsis

Figures & data

Figure 1 Flow chart of case collection.

Table 1 Comparison of CRBN mRNA and Serum CRP and PCT Levels Between the Two Groups

Groups	Number of Cases	CRBN mRNA	CRP (mg/L)	PCT (ng/mL
Control group	130	1.05±0.12	4.55±1.32	0.35±0.12
Sepsis group	130	2.36±0.47	56.18±10.34	11.46±3.36
t	–	30.792	56.473	37.676
P	–	<0.001*	<0.001*	<0.001*

Note: *P < 0.05.

Abbreviations: CRBN, cereblon protein; CRP, C-reactive protein; PCT, procalcitonin.

Table 2 Comparison of CRBN mRNA, CRP and PCT Levels in Patients with Sepsis of Different Severity

Groups	Number of Cases	CRBN mRNA	CRP (mg/L)	PCT (ng/mL)
Mild group	52	1.97±0.35	50.37±6.28	8.54±2.61
Moderate group	45	2.41±0.43^a	57.15±9.85^a	11.32±3.05^a
Severe group	33	2.91±0.32^ab	64.01±5.69^ab	16.25±2.67^ab
F	–	64.738	33.162	77.463
P	–	<0.001*	<0.001*	<0.001*

Notes: Compared with mild group, ^aP < 0.05; Compared with the moderate group, ^bP < 0.05; *P < 0.05.

Abbreviations: CRBN, cereblon protein; CRP, C-reactive protein; PCT, procalcitonin.

Figure 2 Correlation between CRBN mRNA and CRP, PCT, APACHEII score, SOFA score (A) Correlation analysis with CRP; (B) Correlation analysis with PCT; (C) Correlation analysis with APACHEII score; (D) Correlation analysis with SOFA score.

Abbreviations: CRBN, cereblon protein; CRP, C-reactive protein; PCT, procalcitonin; PACHE II, Acute Physiological Function and Chronic Health Status Scoring System II Score; SOFA, Sequential Organ Failure Score.

Figure 3 Correlation between CRBN mRNA expression and 28-day prognosis in sepsis patients.

Abbreviation: CRBN, cereblon protein.

Table 3 Comparison of Serum CRBN mRNA, CRP and PCT Levels Between Survival Group and Death Group

Groups	Number of Cases	CRBN mRNA	CRP (mg/L)	PCT (ng/mL
Survival group	83	2.08±0.45	53.23±8.56	9.53±3.23
Death group	47	2.85±0.36	61.39±7.63	14.87±3.76
t	–	10.046	5.991	8.529
P	–	<0.001*	<0.001*	<0.001*

Note: *P < 0.05.

Abbreviations: CRBN, cereblon protein; CRP, C-reactive protein; PCT, procalcitonin.

Table 4 Prognostic Efficacy of CRBN mRNA, CRP and PCT for Sepsis Patients

Indicators	AUC	95% CI	Cutoff value	Sensitivity	Specificity	Youden Index
CRBN mRNA	0.846	0.773~0.904	2.61	76.60%	81.93%	0.585
CRP	0.822	0.745~0.883	59.60 mg/L	72.34%	84.34%	0.567
PCT	0.865	0.794~0.919	12.10ng/mL	82.98%	78.31%	0.613
Combined diagnosis	0.961	0.911~0.987	–	95.74%	86.75%	0.825

Abbreviations: CRBN, cereblon protein; CRP, C-reactive protein; PCT, procalcitonin.

Figure 4 Prognostic value of CRBN mRNA, CRP and PCT for sepsis patients.

Abbreviations: CRBN, cereblon protein; CRP, C-reactive protein; PCT, procalcitonin.