Recent Advances in the Use of Mesoporous Silica Nanoparticles for the Diagnosis of Bacterial Infections

Figures & data

Figure 1 Schematic representation of the aptamer-based capture platform to identify the pathogen in human blood.

Notes: Adapted from Shen H, Wang J, Liu H, et al. Rapid and Selective Detection of Pathogenic Bacteria in Bloodstream Infections with Aptamer-Based Recognition, ACS Appl. Mater. Interfaces. 2016; 8 (30): 19371–19378. Copyright © 2016, with permission from American Chemical Society.³⁰

Figure 2 Design of organic-inorganic nanoflowers composites for integration in electrochemical detection of E. coli.

Notes: Reprinted from Li Y, Xe G, Qu J, et al. A new biosensor based on the recognition of phages and the signal amplification of organic-inorganic hybrid nanoflowers for discriminating and quantitating live pathogenic bacteria in urine. Sensors and Actuators B: Chemical 2018; 258 (30): 803–812. Copyright © 2017, with permission from Elsevier.⁴⁰

Table 1 Designs of MSNs Employed in MSN Integrated Biosensors for Detection of Bacterial Infections

Design of Nanoparticles	Bacteria	Detection Method	Limit of Detection	Ref.
Hemin encapsulated, DNA gated MSN	E. coli O157:H7 (ATCC 35150) S. aureus (ATCC 25923)	Chemiluminescence	3.0 CFU/mL 2.5 CFU/mL	[^Citation76]
Different sized SiO2-NP	E. coli	Electrochemical	–	[^Citation78]
Anti-E. coli Ab-grafted SiO2-NP	E. coli MRE 162	Electrochemical	2x10^3 CFU/mL	[^Citation79]
MSN@CUR@ZnO@pAbs nanoparticles (MCZP NPs)	S. Typhimurium	Colorimetric Fluorescence	63 CFU/mL 40 CFU/mL	[^Citation86]
Rhodamine B modified silica nanoparticles (SNP-RB)	E. coli (InaCC-B5)	Fluorescence	8 CFU/mL	[^Citation87]
Aptamer-functionalized silica magnetic nanoparticles	S. aureus	Fluorescence	682 CFU/mL	[^Citation94]

Abbreviations: MSN, mesoporous silica nanoparticle; SiO2-NP, non-porous silica nanoparticle; Ab, antibody; MSN@CUR@ZnO@pAbs, mesoporous silica nanoparticle@curcumin@zinc oxide@polyclonal antibody.

Figure 3 (A) Co-condensation of luminophores via covalent bonding and noncovalent interaction in mesoporous siliceous frameworks. (B) Post-synthesis approaches for the addition of optical units into MSN.

Notes: (A) Reprinted from Gao M, Zeng J, Liang K, Zhao D, Kong B. Interfacial Assembly of Mesoporous Silica‐Based Optical Heterostructures for Sensing Applications. Adv. Funct. Mater. 2020, 1906950. Copyright 2020 with permission from WILEY‐VCH.⁸¹

Figure 4 Strategies for incorporation of inorganic species into MSN.

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