Figures & data
Table 1 Rheological properties of DCT-loaded nanomicelles without or with 0.1% NaTC
Figure 2 (A) TEM image of DCT-loaded nanomicelles containing NaTC. (B) Optical images of DCT-loaded nanomicelles at room temperature (liquid; a,b) and biological temperature (solid; c,d). Images correspond to nanomicelles without (a,c) and with NaTC (b,d).
Abbreviations: TEM, transmission electron microscope; DCT, docetaxel; NaTC, sodium taurocholate.
![Figure 2 (A) TEM image of DCT-loaded nanomicelles containing NaTC. (B) Optical images of DCT-loaded nanomicelles at room temperature (liquid; a,b) and biological temperature (solid; c,d). Images correspond to nanomicelles without (a,c) and with NaTC (b,d).Abbreviations: TEM, transmission electron microscope; DCT, docetaxel; NaTC, sodium taurocholate.](/cms/asset/85128f81-9756-40e8-9efa-24e894da8a82/dijn_a_64794_f0002_c.jpg)
Figure 3 Rheological behavior of DCT-loaded nanomicelles for rectal administration at 36.5°C.
Abbreviations: DCT, docetaxel; NaTC, sodium taurocholate.
![Figure 3 Rheological behavior of DCT-loaded nanomicelles for rectal administration at 36.5°C.Abbreviations: DCT, docetaxel; NaTC, sodium taurocholate.](/cms/asset/5a5e5348-92ec-4e19-a454-40dadec92469/dijn_a_64794_f0003_b.jpg)
Figure 4 Plasma concentration-time profiles of DCT-loaded nanomicelles with and without NaTC in rats after rectal administration.
Notes: The DCT-loaded nanomicelle with NaTC was composed of DCT/P407/P188/Tween 80/NaTC (0.25%/11%/15%/10%/0.1%). IV DCT solution was used as a control and each value represents the mean ± standard deviation (n=6). *Significantly higher than plain nanomicelle group (P<0.05).
Abbreviations: DCT, docetaxel; NaTC, sodium taurocholate; IV, intravenous; Na, sodium.
![Figure 4 Plasma concentration-time profiles of DCT-loaded nanomicelles with and without NaTC in rats after rectal administration.Notes: The DCT-loaded nanomicelle with NaTC was composed of DCT/P407/P188/Tween 80/NaTC (0.25%/11%/15%/10%/0.1%). IV DCT solution was used as a control and each value represents the mean ± standard deviation (n=6). *Significantly higher than plain nanomicelle group (P<0.05).Abbreviations: DCT, docetaxel; NaTC, sodium taurocholate; IV, intravenous; Na, sodium.](/cms/asset/6439b91d-c8a3-49d8-9725-2596ecc383bd/dijn_a_64794_f0004_c.jpg)
Table 2 Pharmacokinetic parameters of rectally administered DCT-loaded nanomicelles (without or with 0.1% NaTC) and intravenous DCT solution at a dose of 5 mg/kg