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Original Research

The influence of bile salt on the chemotherapeutic response of docetaxel-loaded thermosensitive nanomicelles

, , , , , & show all
Pages 3815-3824 | Published online: 08 Aug 2014

Figures & data

Table 1 Rheological properties of DCT-loaded nanomicelles without or with 0.1% NaTC

Figure 1 Schematic illustration of the preparation of DCT-loaded nanomicelles containing NaTC.

Figure 1 Schematic illustration of the preparation of DCT-loaded nanomicelles containing NaTC.

Figure 2 (A) TEM image of DCT-loaded nanomicelles containing NaTC. (B) Optical images of DCT-loaded nanomicelles at room temperature (liquid; a,b) and biological temperature (solid; c,d). Images correspond to nanomicelles without (a,c) and with NaTC (b,d).

Abbreviations: TEM, transmission electron microscope; DCT, docetaxel; NaTC, sodium taurocholate.

Figure 2 (A) TEM image of DCT-loaded nanomicelles containing NaTC. (B) Optical images of DCT-loaded nanomicelles at room temperature (liquid; a,b) and biological temperature (solid; c,d). Images correspond to nanomicelles without (a,c) and with NaTC (b,d).Abbreviations: TEM, transmission electron microscope; DCT, docetaxel; NaTC, sodium taurocholate.

Figure 3 Rheological behavior of DCT-loaded nanomicelles for rectal administration at 36.5°C.

Abbreviations: DCT, docetaxel; NaTC, sodium taurocholate.

Figure 3 Rheological behavior of DCT-loaded nanomicelles for rectal administration at 36.5°C.Abbreviations: DCT, docetaxel; NaTC, sodium taurocholate.

Figure 4 Plasma concentration-time profiles of DCT-loaded nanomicelles with and without NaTC in rats after rectal administration.

Notes: The DCT-loaded nanomicelle with NaTC was composed of DCT/P407/P188/Tween 80/NaTC (0.25%/11%/15%/10%/0.1%). IV DCT solution was used as a control and each value represents the mean ± standard deviation (n=6). *Significantly higher than plain nanomicelle group (P<0.05).

Abbreviations: DCT, docetaxel; NaTC, sodium taurocholate; IV, intravenous; Na, sodium.

Figure 4 Plasma concentration-time profiles of DCT-loaded nanomicelles with and without NaTC in rats after rectal administration.Notes: The DCT-loaded nanomicelle with NaTC was composed of DCT/P407/P188/Tween 80/NaTC (0.25%/11%/15%/10%/0.1%). IV DCT solution was used as a control and each value represents the mean ± standard deviation (n=6). *Significantly higher than plain nanomicelle group (P<0.05).Abbreviations: DCT, docetaxel; NaTC, sodium taurocholate; IV, intravenous; Na, sodium.

Table 2 Pharmacokinetic parameters of rectally administered DCT-loaded nanomicelles (without or with 0.1% NaTC) and intravenous DCT solution at a dose of 5 mg/kg

Figure 5 Anti-tumor efficacy of DCT-loaded nanomicelles with and without NaTC after rectal administration.

Notes: Each value represents the mean ± standard deviation (n=7). *Significantly smaller than control group (P<0.01).

Abbreviations: DCT, docetaxel; NaTC, sodium taurocholate.

Figure 5 Anti-tumor efficacy of DCT-loaded nanomicelles with and without NaTC after rectal administration.Notes: Each value represents the mean ± standard deviation (n=7). *Significantly smaller than control group (P<0.01).Abbreviations: DCT, docetaxel; NaTC, sodium taurocholate.

Figure 6 Body weight changes of tumor-bearing nude mice after rectal administration of DCT-loaded nanomicelles with and without NaTC.

Note: Each value represents the mean ± standard deviation (n=7).

Abbreviations: DCT, docetaxel; NaTC, sodium taurocholate.

Figure 6 Body weight changes of tumor-bearing nude mice after rectal administration of DCT-loaded nanomicelles with and without NaTC.Note: Each value represents the mean ± standard deviation (n=7).Abbreviations: DCT, docetaxel; NaTC, sodium taurocholate.