Figures & data
Table 1 Association of Pre-S1 Single Test Result with Clinical Parameters
Table 2 Association of Pre-S1 Single Test Result with Other HBV Markers
Table 3 Single and Multivariate Analysis for the Association of Clinical Factors with HCC Risk in Chronic HBV Infected Patients
Table 4 The Association Between Four Pre-S1 Follow-Up Modes with Cirrhosis and HCC, and Antiviral Treatment
Table 5 Single and Multivariate Analysis for the Association of Clinical Factors with HCC Risk in Chronic HBV Infected Patients with Sustained Pre-S1 Test Results
Table 6 Information of Pre-S1 Sequence Results of Pre-S1 Negative and Positive, Treatment Naïve Patients
Figure 1 Pre-S1 amino acid sequences of pre-S1 positive and Pre-S1 negative treatment naïve patients. (A) The pre-S1 amino acid sequence of pre-S1 positive patient 1 (Seq_1) was consistent with D-type HBV. (B) The sample of pre-S1 negative patient 2 contained two pre-S1 sequences. Compared with C-type HBV, Seq_1 of the pre-S1 amino acid sequence had only one site mutation (V90A); another pre-S1 sequence had frame shift mutation resulting the mutation and premature termination. (C) Sequence analysis showed that the sample of pre-S1 negative patient 3 contained three pre-S1 sequences. Among them, the amino acid sequence of pre-S1 Seq_1 was identical with that of C type HBV; pre-S1 Seq_2 and Seq_3 contained deletion mutations.
![Figure 1 Pre-S1 amino acid sequences of pre-S1 positive and Pre-S1 negative treatment naïve patients. (A) The pre-S1 amino acid sequence of pre-S1 positive patient 1 (Seq_1) was consistent with D-type HBV. (B) The sample of pre-S1 negative patient 2 contained two pre-S1 sequences. Compared with C-type HBV, Seq_1 of the pre-S1 amino acid sequence had only one site mutation (V90A); another pre-S1 sequence had frame shift mutation resulting the mutation and premature termination. (C) Sequence analysis showed that the sample of pre-S1 negative patient 3 contained three pre-S1 sequences. Among them, the amino acid sequence of pre-S1 Seq_1 was identical with that of C type HBV; pre-S1 Seq_2 and Seq_3 contained deletion mutations.](/cms/asset/f0b11fee-85d8-491b-a2dc-ec728d33b2ec/djhc_a_12156822_f0001_c.jpg)