255
Views
0
CrossRef citations to date
0
Altmetric
ORIGINAL RESEARCH

Pre-S1 Mutations as Indicated by Serum Pre-S1 Antigen Negative is Associated with an Increased Risk of Hepatocellular Carcinoma in Chronic Hepatitis B Patients

, , , , , , ORCID Icon & ORCID Icon show all
Pages 599-609 | Received 02 Feb 2023, Accepted 06 Apr 2023, Published online: 11 Apr 2023

References

  • Stanaway JD, Flaxman AD, Naghavi M, et al. The global burden of viral hepatitis from 1990 to 2013: findings from the Global Burden of Disease Study 2013. Lancet. 2016;388:1081–1088. doi:10.1016/S0140-6736(16)30579-7
  • Zhang S, Wang F, Zhang Z. Current advances in the elimination of hepatitis B in China by 2030. Front Med. 2017;11:490–501. doi:10.1007/s11684-017-0598-4
  • Cai Y, Jia J. Update on epidemiology of hepatitis B and C in China. J Gastroenterol Hepatol. 2013;28:7–10. doi:10.1111/jgh.12220
  • Fattovich G. Natural history of hepatitis B. J Hepatol. 2003;39:S50–S58. doi:10.1016/S0168-8278(03)00139-9
  • Trépo C, Chan HL, Lok A. Hepatitis B virus infection. Lancet. 2014;384:2053–2063. doi:10.1016/S0140-6736(14)60220-8
  • Sarin SK, Kumar M, Eslam M, et al. Liver diseases in the Asia-Pacific region: a Lancet Gastroenterology & Hepatology Commission. Lancet Gastroenterol Hepatol. 2020;5:167–228. doi:10.1016/S2468-1253(19)30342-5
  • Liu CJ, Kao JH. Global perspective on the natural history of chronic hepatitis B: role of hepatitis B virus genotypes A to J. Semin Liver Dis. 2013;33:97–102. doi:10.1055/s-0033-1345716
  • Zhang Q, Cao GW, Zhang H. Genotypes, mutations, and viral load of hepatitis B virus and the risk of hepatocellular carcinoma: HBV properties and hepatocarcinogenesis. Hepat Mon. 2011;11:86–91. doi:10.1002/cncr.25522
  • Tian QJ, Jia JD. Hepatitis B virus genotypes: epidemiological and clinical relevance in Asia. Hepatol Int. 2016;10:854–860. doi:10.1007/s12072-016-9745-2
  • Chen BF. Hepatitis B virus pre-S/S variants in liver diseases. World J Gastroenterol. 2018;24:1507–1520. doi:10.3748/wjg.v24.i14.1507
  • Sugauchi F, Ohno T, Orito E, et al. Influence of hepatitis B virus genotypes on the development of preS deletions and advanced liver disease. J Med Virol. 2003;70:537–544. doi:10.1002/jmv.10428
  • Choi MS, Kim DY, Lee DH, et al. Clinical significance of pre-S mutations in patients with genotype C hepatitis B virus infection. J Viral Hepat. 2007;14:161–168. doi:10.1111/j.1365-2893.2006.00784.x
  • Hu JM, Liu KC. Complete and incomplete hepatitis B virus particles: formation, function, and application. Viruses. 2017;9:56. doi:10.3390/v9030056
  • Meier A, Mehrle S, Weiss TS, et al. Myristoylated PreS1-domain of the hepatitis B virus L-protein mediates specific binding to differentiated hepatocytes. Hepatology. 2013;58(1):31–42. PMID: 23213046. doi:10.1002/hep.26181
  • Yan H, Zhong G, Xu G, et al. Sodium taurocholate cotransporting polypeptide is a functional receptor for human hepatitis B and D virus. eLife. 2012;1:e00049. doi:10.7554/eLife.00049
  • Hadziyannis S, Gerber MA, Vissoulis C, et al. Cytoplasmic hepatitis B antigen in “ground-glass” hepatocytes of carriers. Arch Pathol. 1973;96:327–330.
  • Popper H. The ground glass hepatocyte as a diagnostic hint. Hum Pathol. 1975;6:517–520. doi:10.1016/S0046-8177(75)80069-4
  • Jiang B, Wu Q, Kuhnhenn L, et al. Formation of semi-enveloped particles as a unique feature of a hepatitis B virus PreS1 deletion mutant. Aliment Pharmacol Ther. 2019;50:940–954. doi:10.1111/apt.15381
  • Ogura S, Tameda M, Sugimoto K, et al. A substitution in the pre-S1 promoter region is associated with the viral regulation of hepatitis B virus. Virol J. 2019;16:59. doi:10.1186/s12985-019-1169-x
  • Fan YF, Lu CC, Chen WC, et al. Prevalence and significance of hepatitis B virus (HBV) pre-S mutants in serum and liver at different replicative stages of chronic HBV infection. Hepatology. 2001;33:277–286. doi:10.1053/jhep.2001.21163
  • Gao ZY, Li T, Wang J, et al. Mutations in preS genes of genotype C hepatitis B virus in patients with chronic hepatitis B and hepatocellular carcinoma. J Gastroenterol. 2007;42:761–768. doi:10.1007/s00535-007-2085-1
  • Jang JS, Kim HS, Kim HJ, et al. Association of concurrent hepatitis B surface antigen and antibody to hepatitis B surface antigen with hepatocellular carcinoma in chronic hepatitis B virus infection. J Med Virol. 2009;81:1531–1538. doi:10.1002/jmv.21577
  • van Ditzhuijsen TJ, Kuijpers LP, Koens MJ, et al. Hepatitis B pre-S1 and pre-S2 proteins: clinical significance and relation to hepatitis B virus DNA. J Med Virol. 1990;32(2):87–91. doi:10.1002/jmv.1890320204
  • Locarnini S, Zoulim F. Molecular genetics of HBV infection. Antivir Ther. 2010;15(Suppl 3):3–14. doi:10.3851/IMP1619
  • Lin WL, Hung JH, Huang W. Association of the hepatitis B virus large surface protein with viral infectivity and endoplasmic reticulum stress-mediated liver carcinogenesis. Cells. 2020;9:2052. doi:10.3390/cells9092052
  • Liu W, Cai S, Pu R, et al. HBV preS mutations promote hepatocarcinogenesis by inducing endoplasmic reticulum stress and upregulating inflammatory signaling. Cancers. 2022;14(13):3274. doi:10.3390/cancers14133274
  • Su IJ, Wang HC, Wu HC, et al. Ground glass hepatocytes contain pre-S mutants and represent preneoplastic lesions in chronic hepatitis B virus infection. J Gastroenterol Hepatol. 2008;23:1169–1174. doi:10.1111/j.1440-1746.2008.05348.x
  • Chen BF, Liu CJ, Jow GM, et al. High prevalence and mapping of pre-S deletion in hepatitis B virus carriers with progressive liver diseases. Gastroenterology. 2006;130(4):1153–1168. doi:10.1053/j.gastro.2006.01.011
  • Huy TT, Ushijima H, Win KM, et al. High prevalence of hepatitis B virus pre-S mutant in countries where it is endemic and its relationship with genotype and chronicity. J Clin Microbiol. 2003;41:5449–5455. doi:10.1128/JCM.41.12.5449-5455.2003
  • Yin J, Xie J, Zhang H, et al. Significant association of different preS mutations with hepatitis B-related cirrhosis or hepatocellular carcinoma. J Gastroenterol. 2010;45(10):1063–1071. doi:10.1007/s00535-010-0253-1
  • Teng CF, Wu HC, Su IJ, et al. Hepatitis B virus pre-S mutants as biomarkers and targets for the development and recurrence of hepatocellular carcinoma. Viruses. 2020;12:945. doi:10.3390/v12090945
  • Teng CF, Li TC, Huang HY, et al. Next-generation sequencing-based quantitative detection of hepatitis B virus pre-S mutants in plasma predicts hepatocellular carcinoma recurrence. Viruses. 2020;12:796. doi:10.3390/v12080796
  • Choi YM, Lee SY, Kim BJ. Naturally occurring hepatitis B virus mutations leading to endoplasmic reticulum stress and their contribution to the progression of hepatocellular carcinoma. Int J Mol Sci. 2019;20:597. doi:10.3390/ijms20030597
  • Sarin SK, Kumar M, Lau GK, et al. Asian-Pacific clinical practice guidelines on the management of hepatitis B: a 2015 update. Hepatol Int. 2016;10:1–98. doi:10.1007/s12072-015-9675-4
  • World Health Organization. Guidelines for the Prevention, Care and Treatment of Persons with Chronic Hepatitis B Infection. Geneva, Switzerland: World Health Organization; 2015. PMID: 26225396 Bookshelf ID: NBK305553.
  • European Association for the Study of the Liver. EASL 2017 Clinical Practice Guidelines on the management of hepatitis B virus infection. J Hepatol. 2017;67:370–398. doi:10.1016/j.jhep.2017.03.021
  • Terrault NA, Lok ASF, McMahon BJ, et al. Update on prevention, diagnosis, and treatment of chronic hepatitis B: AASLD 2018 hepatitis B guidance. Hepatology. 2018;67:1560–1599. doi:10.1002/hep.29800
  • Yim HJ, Kim JH, Park JY, et al. Comparison of clinical practice guidelines for the management of chronic hepatitis B: when to start, when to change, and when to stop. Clin Mol Hepatol. 2020;26:411–429. doi:10.3350/cmh.2020.0049
  • Dias JD, Sarica N, Neuveut C. Early steps of hepatitis B life cycle: from capsid nuclear import to cccDNA formation. Viruses. 2021;13:757. doi:10.3390/v13050757
  • Martinez MG, Boyd A, Combe E, et al. Covalently closed circular DNA: the ultimate therapeutic target for curing hepatitis B virus infections. J Hepatol. 2021;75:706–717. doi:10.1016/j.jhep.2021.05.013
  • Meier M, Calabrese D, Suslov A, et al. Ubiquitous expression of HBsAg from integrated HBV DNA in patients with low viral load. J Hepatol. 2021;75(4):840–847. doi:10.1016/j.jhep.2021.04.051
  • Tsai HW, Lin YJ, Wu HC, et al. Resistance of ground glass hepatocytes to oral antivirals in chronic hepatitis B patients and implication for the development of hepatocellular carcinoma. Oncotarget. 2016;7:27724–27734. doi:10.18632/oncotarget.8388
  • Coppola N, Onorato L, Minichini C, et al. Clinical significance of hepatitis B surface antigen mutants. World J Hepatol. 2015;7:2729–2739. doi:10.4254/wjh.v7.i27.2729