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Journal of Inflammation Research Volume 14, 2021 - Issue
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Original Research

The Influence of an Occult Infection on the Outcome of Autologous Bone Grafting During Surgical Bone Reconstruction: A Large Single-Center Case-Control Study

Michael C Tanner1 HTRG – Heidelberg Trauma Research Group, Center for Orthopedics, Trauma Surgery and Spinal Cord Injury, Trauma and Reconstructive Surgery, Heidelberg University Hospital, Heidelberg, D-69118, GermanyORCID Iconhttps://orcid.org/0000-0003-0243-8113View further author information
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Raban Arved Heller1 HTRG – Heidelberg Trauma Research Group, Center for Orthopedics, Trauma Surgery and Spinal Cord Injury, Trauma and Reconstructive Surgery, Heidelberg University Hospital, Heidelberg, D-69118, Germany;2 Institute for Experimental Endocrinology, Charité - Universitätsmedizin Berlin, Freie Universität Berlin, Humboldt Universität Zu Berlin, Berlin Institute of Health, Berlin, D-13353, Germany;3 Department of General Practice and Health Services Research, Heidelberg University Hospital, Heidelberg, D-69120, GermanyORCID Iconhttps://orcid.org/0000-0001-8006-9742View further author information
ORCID Icon,
Andreas Grimm1 HTRG – Heidelberg Trauma Research Group, Center for Orthopedics, Trauma Surgery and Spinal Cord Injury, Trauma and Reconstructive Surgery, Heidelberg University Hospital, Heidelberg, D-69118, GermanyView further author information
,
Stefan Zimmermann4 Division Bacteriology, Department of Infectious Diseases, Heidelberg University Hospital, Heidelberg, D-69120, GermanyView further author information
,
Maximilian Pilz5 Institute of Medical Biometry and Informatics, Heidelberg University Hospital, Heidelberg, D-69120, GermanyView further author information
,
Louisa Jurytko1 HTRG – Heidelberg Trauma Research Group, Center for Orthopedics, Trauma Surgery and Spinal Cord Injury, Trauma and Reconstructive Surgery, Heidelberg University Hospital, Heidelberg, D-69118, GermanyView further author information
,
Matthias Miska1 HTRG – Heidelberg Trauma Research Group, Center for Orthopedics, Trauma Surgery and Spinal Cord Injury, Trauma and Reconstructive Surgery, Heidelberg University Hospital, Heidelberg, D-69118, GermanyView further author information
,
Lars Helbig1 HTRG – Heidelberg Trauma Research Group, Center for Orthopedics, Trauma Surgery and Spinal Cord Injury, Trauma and Reconstructive Surgery, Heidelberg University Hospital, Heidelberg, D-69118, GermanyORCID Iconhttps://orcid.org/0000-0002-5648-2657View further author information
ORCID Icon,
Gerhard Schmidmaier1 HTRG – Heidelberg Trauma Research Group, Center for Orthopedics, Trauma Surgery and Spinal Cord Injury, Trauma and Reconstructive Surgery, Heidelberg University Hospital, Heidelberg, D-69118, GermanyORCID Iconhttps://orcid.org/0000-0002-6711-7380View further author information
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Patrick Haubruck1 HTRG – Heidelberg Trauma Research Group, Center for Orthopedics, Trauma Surgery and Spinal Cord Injury, Trauma and Reconstructive Surgery, Heidelberg University Hospital, Heidelberg, D-69118, Germany;6 Raymond Purves Bone and Joint Research Laboratory, Institute of Bone and Joint Research, Kolling Institute, Royal North Shore Hospital, University of Sydney, St. Leonards, New South Wales, A-2068, AustraliaCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0002-7045-0387View further author information
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Pages 995-1005 | Published online: 22 Mar 2021

Figures & data

Table 1 Patients’ Characteristics of the Entire Collective

Table 2 Patients Characteristics of the Study Group (SG)

Figure 1 The patient allocation and inclusion process into individual analyses is visualized.

Abbreviation: OP, operative procedure.
Figure 1 The patient allocation and inclusion process into individual analyses is visualized.

Figure 2 (A) shows the healing and outcome of patients suffering from an OI (study) and patients without OI (control). Duration is shown in years, while outcome is shown as percentages (here 1 equals 100%). (B) visualizes the predictive performance of different computational models that were compared. While 1 shows the final model included into our study, 2 and 3 depict the performance of models including merely one variable.

Figure 2 (A) shows the healing and outcome of patients suffering from an OI (study) and patients without OI (control). Duration is shown in years, while outcome is shown as percentages (here 1 equals 100%). (B) visualizes the predictive performance of different computational models that were compared. While 1 shows the final model included into our study, 2 and 3 depict the performance of models including merely one variable.

Figure 3 (A) shows the individual pathogens found during microbiological analysis of intraoperative tissue samples for responder (consolidation) and non-responder (no consolidation) of treatment. (B) Pathogens were summarized into coherent groups of bacteria by an experienced microbiologist.

Figure 3 (A) shows the individual pathogens found during microbiological analysis of intraoperative tissue samples for responder (consolidation) and non-responder (no consolidation) of treatment. (B) Pathogens were summarized into coherent groups of bacteria by an experienced microbiologist.

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