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Original Research

Undetected Jawbone Marrow Defects as Inflammatory and Degenerative Signaling Pathways: Chemokine RANTES/CCL5 as a Possible Link Between the Jawbone and Systemic Interactions?

ORCID Icon, ORCID Icon, &
Pages 1603-1612 | Published online: 21 Apr 2021

Figures & data

Figure 1 Example of a DVT-HU measurement of a BMDJ following clinical evaluation. The HU attenuation coefficients are shown as a curve over the measured section. In the present validation study, only the mean values (MV) are used.

Figure 1 Example of a DVT-HU measurement of a BMDJ following clinical evaluation. The HU attenuation coefficients are shown as a curve over the measured section. In the present validation study, only the mean values (MV) are used.

Figure 2 Comparison of R/C expression and cytokine pattern in degenerative (tumors) and systemic inflammatory diseases (CFS).

Abbreviations: n, number; CFS, chronic fatigue syndrome; norm, healthy controls; FGF, fibroblast growth factor; IL, interleukin; MCP, monocyte chemotactic protein; TNFa, tumor necrosis factor-alpha.
Figure 2 Comparison of R/C expression and cytokine pattern in degenerative (tumors) and systemic inflammatory diseases (CFS).

Figure 3 Typical samples of BMDJ/FDOJ with complete dissolution of the bone trabecula. Below the sample, the head of a ceramic drill with a 2 mm diameter is shown to provide a size comparison.

Figure 3 Typical samples of BMDJ/FDOJ with complete dissolution of the bone trabecula. Below the sample, the head of a ceramic drill with a 2 mm diameter is shown to provide a size comparison.

Table 1 Statistical Analysis Results of the DVT-HU Values in Each Group

Table 2 Statistical Analysis Results of the R/C Expression Levels in Each Group

Table 3 This Table Shows the Mean Values of DVT-HU and R/C Expression for Focal BMDJ/FDOJ for Each Chronic Disease Group

Figure 4 A significant reduction in HU values was observed in BMD areas, with measured values falling well below the minimum value for healthy cancellous bone (ie, 300), as represented by the green line.

Figure 4 A significant reduction in HU values was observed in BMD areas, with measured values falling well below the minimum value for healthy cancellous bone (ie, 300), as represented by the green line.

Figure 5 R/C signaling is overexpressed for all chronic disease groups compared to the common value of 149,9 pg/mL for healthy cancellous jawbone (shown by the green line).

Figure 5 R/C signaling is overexpressed for all chronic disease groups compared to the common value of 149,9 pg/mL for healthy cancellous jawbone (shown by the green line).