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Original Research

Prognostic and Predictive Value of Circulating Inflammation Signature in Non-Metastatic Nasopharyngeal Carcinoma: Potential Role for Individualized Induction Chemotherapy

, ORCID Icon, , , & ORCID Icon
Pages 2225-2237 | Published online: 25 May 2021

Figures & data

Table 1 Patient Characteristics

Figure 1 Schematic illustration of the study design.

Figure 1 Schematic illustration of the study design.

Figure 2 Circulating inflammation signature selection using LASSO Cox regression. (A) Tuning parameter lambda (λ) selection in the LASSO method using ten-fold cross-validation via minimum criteria. (B) LASSO coefficient profiles of the candidate inflammatory markers.

Figure 2 Circulating inflammation signature selection using LASSO Cox regression. (A) Tuning parameter lambda (λ) selection in the LASSO method using ten-fold cross-validation via minimum criteria. (B) LASSO coefficient profiles of the candidate inflammatory markers.

Table 2 The Results of Univariate and Stepwise Multivariate Analyses in the Training Cohort

Figure 3 The distribution of circulating inflammation signature values in the training cohort. (A). The association between the circulating inflammation signature value and the estimated 3- and 5-year DFS probabilities (B).

Figure 3 The distribution of circulating inflammation signature values in the training cohort. (A). The association between the circulating inflammation signature value and the estimated 3- and 5-year DFS probabilities (B).

Figure 4 Crude survival curves, stratified by the circulating inflammation signature (CISIG) values in the training cohort (A) and validation cohort (B).

Figure 4 Crude survival curves, stratified by the circulating inflammation signature (CISIG) values in the training cohort (A) and validation cohort (B).

Table 3 C-Indices and Corresponding 95% CIs of All Prognostic Models

Figure 5 Circulating inflammation signature (CISIG)-based nomogram (A) for estimating the 1-, 3- and 5-year disease-free survival rates in nasopharyngeal carcinoma patients. The calibration curve at 1-, 3-, and 5-year timepoints for the CISIG-based nomogram in the training cohort (B) and validation cohort (C).

Figure 5 Circulating inflammation signature (CISIG)-based nomogram (A) for estimating the 1-, 3- and 5-year disease-free survival rates in nasopharyngeal carcinoma patients. The calibration curve at 1-, 3-, and 5-year timepoints for the CISIG-based nomogram in the training cohort (B) and validation cohort (C).