Predictive Value of the Platelet-to-Albumin Ratio (PAR) on the Risk of Death at Admission in Patients Suffering from Severe Fever with Thrombocytopenia Syndrome

Figures & data

Table 1 The Basic Characteristics of the Patients

Variables	Survival (n=91)	Fatal (n=36)	P value
Gender [n (%)]
Male	41 (67.2)	20 (32.8)	0.328
Female	50 (75.8)	16 (24.2)
Age (years)	60.36±10.97	67.14±8.78	0.001
WBC (10 9 /L)	2.75 (1.84, 4.62)	2.42 (1.29, 4.48)	0.301
NEU (10 9 /L)	1.55 (0.88, 2.56)	1.46 (0.79, 3.67)	0.877
LYM (10 9 /L)	0.8 (0.5, 1.12)	0.5 (0.35, 0.867)	0.007
MON (10 9 /L)	0.12 (0.07, 0.27)	0.07 (0.05, 0.16)	0.014
Hb (g/L)	126 (115, 140)	129.5 (120, 139)	0.454
PLT (10 9 /L)	48 (36, 66)	36 (31, 45.75)	<0.001
ALT (U/L)	71 (47, 113)	130 (65.5, 199.5)	0.003
AST (U/L)	147 (93, 242)	396 (200, 679.75)	<0.001
ALB (g/L)	33.4 (29.6, 37.3)	32.6 (30.5, 34.08)	<0.001
UA (μmol/L)	237 (189, 308)	364.5 (235, 487)	<0.001
BUN (mmol/L)	4.87 (3.58, 6.36)	8.92 (6.08, 15.13)	<0.001
PT (s)	13 (12.4, 13.6)	13.6 (12.85, 14.65)	0.001
APTT (s)	50.7 (43.2, 55.7)	65.95 (58.45, 83.33)	<0.001
PAR	1.46 (1.11, 1.87)	1.12 (0.95, 1.35)	<0.001

Abbreviations: WBC, white blood cell; NEU, neutrophil; LYM, lymphocyte; MON, monocyte; Hb, hemoglobin; PLT, platelet count; BUN, blood urea nitrogen; PT, prothrombin time; APTT, activated partial thromboplastin time; ALT, alanine aminotransferase; AST, aspartate aminotransferase; ALB, albumin; UA, uric acid; PAR, platelet-to-albumin ratio.

Figure 1 The number of confirmed cases was grouped by year and quarter.

Table 2 The Variables and Assignments of SFTS Risk Factors Analysis

Variable Name	Assignment Description
Sex	Male =1	Female =2
Age (years)	≥65=1	<65=0
WBC (10 9 /L)	>10=1	≤10=0
NEU (10 9 /L)	>7.5=1	≤7.5=0
LYM (10 9 /L)	<0.8=1	≥ 0.8=0
MON (10 9 /L)	<0.3=1	≥ 0.3=0
Hb (g/L)	<110=1	≥ 110=0
ALT (U/L)	>120=1	≤120=0
AST (U/L)	>120=1	≤120=0
ALB (g/L)	<25=1	≥25=0
UA (μmol/L)	>420=1	≤420=0
BUN (mmol/L)	>7=1	≤7=0
PT (s)	>17=1	≤17=0
APTT (s)	>47=1	≤47=0
PAR	>1.43=1	≤1.43=0

Abbreviations: WBC, white blood cell; NEU, neutrophil; LYM, lymphocyte; MON, monocyte; Hb, hemoglobin; BUN, blood urea nitrogen; PT, prothrombin time; APTT, activated partial thromboplastin time; ALT, alanine aminotransferase; AST, aspartate aminotransferase; ALB, albumin; UA, uric acid; PAR, platelet-to-albumin ratio.

Table 3 Univariable and Multivariable Logistic Regression Analyses of the Various Features Associated with the Fatal Outcomes in Patients with SFTS

	Univariable Analysis				Multivariable Analysis
	OR	P	95% CI for HR		OR	P	95% CI for HR
			Lower	Upper			Lower	Upper
Sex	1.524	0.287	0.701	3.313
Age	0.275	0.002	0.12	0.628	0.208	0.005	0.069	0.63
WBC	1.025	0.726	0.893	1.177
NE	0.995	0.947	0.858	1.154
LYM	0.376	0.022	0.163	0.869
MON	0.474	0.205	0.149	1.505
Hb	1.671	0.449	0.442	6.31
PLT	1.062	<0.001	1.028	1.096
BUN	0.123	<0.001	0.052	0.292	0.236	0.014	0.074	0.751
UA	0.194	0.001	0.074	0.511
PT	0.122	0.073	0.012	1.217
APTT	0.108	0.003	0.024	0.481
ALT	0.268	0.002	0.119	0.607
AST	0.127	0.001	0.036	0.444
ALB	1.065	0.16	0.976	1.162
PAR	7.561	<0.001	2.697	21.198	4.023	0.024	1.204	13.436

Note: Adjusted for age, sex, AST, ALT, BUN and UA.

Abbreviations: WBC, white blood cell; NEU, neutrophil; LYM, lymphocyte; MON, monocyte; Hb, hemoglobin; PLT, platelet count; BUN, blood urea nitrogen; PT, prothrombin time; APTT, activated partial thromboplastin time; ALT, alanine aminotransferase; AST, aspartate aminotransferase; ALB, albumin; UA, uric acid; PAR, platelet-to-albumin ratio.

Figure 2 The distribution of SFTS in high or low PAR groups.