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Original Research

Systemic Immune-Inflammatory Index as a Predictor of Lymph Node Metastasis in Endometrial Cancer

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Pages 7131-7142 | Published online: 21 Dec 2021

Figures & data

Table 1 Baseline Characteristics of EC Patients

Figure 1 Characteristics of inflammatory immune cells in EC with LNM and no LNM.

Note: *P < 0.05. P<0.05 indicates significant differences.
Abbreviations: WBC, white blood cell; NE, neutrophil; MO, monocyte; PLT, platelet count; Lym, lymphocyte; SII, systemic immune-inflammatory index; NK, natural killer.
Figure 1 Characteristics of inflammatory immune cells in EC with LNM and no LNM.

Figure 2 The ROC curve. The ROC curve for NE, MO, SII, CA125, CA199, CA153, and Ki67. The cutoff values for these indicators were identified. P<0.05 indicates significant differences.

Abbreviations: NE, neutrophil; MO, monocyte; SII, systemic immune-inflammatory index; CA125, cancer antigen 125; CA153, cancer antigen 153; CA199, cancer antigen 199.
Figure 2 The ROC curve. The ROC curve for NE, MO, SII, CA125, CA199, CA153, and Ki67. The cutoff values for these indicators were identified. P<0.05 indicates significant differences.

Figure 3 The logistic regression analyses. (A) Univariate logistic regression analyses for LNM. (B) Multivariate logistic regression analyses for LNM. P<0.05 indicates significant differences.

Figure 3 The logistic regression analyses. (A) Univariate logistic regression analyses for LNM. (B) Multivariate logistic regression analyses for LNM. P<0.05 indicates significant differences.

Figure 4 (A) The nomogram for predicting LNM with SII, CA125, CA153, and LVSI. (B) The calibration plots for the nomogram. (C) The ROC curve for the nomogram.

Figure 4 (A) The nomogram for predicting LNM with SII, CA125, CA153, and LVSI. (B) The calibration plots for the nomogram. (C) The ROC curve for the nomogram.

Table 2 Associations of SII with Clinicopathological Characteristics

Table 3 Correlations Between Clinical or Biochemical Parameters and SII in EC Patients

Figure 5 The logistic regression analyses. (A) Multivariate logistic regression analyses for myometrial invasion in premenopausal young EC. (B) Multivariate logistic regression analyses for histologic grade in premenopausal young EC. (C) Multivariate logistic regression analyses for FIGO stage in postmenopausal or age≥55 EC.

Note: P<0.05 indicates significant differences.
Abbreviations: SII, Systemic Immune-Inflammatory Index; FIGO, International Federation of Gynecology and Obstetrics; ORadjust, OR adjust for age; Padjust, P value adjusted for age.
Figure 5 The logistic regression analyses. (A) Multivariate logistic regression analyses for myometrial invasion in premenopausal young EC. (B) Multivariate logistic regression analyses for histologic grade in premenopausal young EC. (C) Multivariate logistic regression analyses for FIGO stage in postmenopausal or age≥55 EC.