Effect of Helicobacter Pylori Infection on Glucose Metabolism, Lipid Metabolism and Inflammatory Cytokines in Nonalcoholic Fatty Liver Disease Patients

Figures & data

Table 1 Comparison of Baseline Data Between Two Groups

Clinical Data	Study Group (n=73)	Control Group (n=67)	χ^2/t	95% CI	P
Gender (Male/Female)	37/36	32/35	0.119	0.579–2.183	0.730
Age (years, x±s)	51.21± 9.76	53.0±12.0	1.371	−5.433–1.853	0.252
Height (cm, x±s)	158.45±9.73	159.66±10.37	1.122	−4.549–2.129	0.275
BMI (kg/m^2, x±s)	19.52±7.63	20.32±8.75	0.798	−3.530–1.930	0.440
Disease duration (years, x±s)	9.51±2.53	9.75±2.56	1.735	−1.084–0.604	0.145
Smoking history (cases)	31	29	0.010	0.495–1.890	0.922
History of hypertension (cases)	28	30	0.593	0.391–1.506	0.441
History of diabetes (cases)	14	17	0.778	0.313–1.555	0.378
ALT (μ mol/L)	53.13±9.36	53.99±9.97	0.132	−4.071–2.351	0.600
AST (μ mol/L)	52.08±10.12	51.39±10.26	0.576	−2.690–4.070	0.690

Abbreviations: CI, Confidence interval; BMI, Body mass index; ALT, Alanine aminotransferase; AST, Aspartate aminotransferase.

Table 2 Comparison of Glucose Metabolism Indicators Between Two Groups (x±s)

Glucose Metabolism Indicator	Study Group (n=73)	Control Group (n=67)	t value	95% CI	P value
FBG (mmol/L)	5.84±0.49	5.40±0.51	2.535	0.274–0.606	0.012
2hPG (mmol/L)	7.26±1.30	6.50±1.53	3.321	0.288–1.233	<0.001
FINS (mIU/L)	11.13±4.13	9.12±3.72	3.224	0.710–3.310	<0.001
HOMA-IR	2.97±0.35	2.13±0.54	3.761	0.688–0.992	<0.001
HbAlc (%)	5.25±0.56	6.12±0.57	5.473	−1.057--0.683	<0.001

Abbreviations: CI, Confidence interval; FBG, Fasting blood glucose; 2hPG, 2-hour postprandial glucose; FINS, Fasting insulin; HbA1c, Glycated hemoglobin; HOMA-IR, Insulin resistance index.

Table 3 Comparison of Lipid Metabolism Indicators Between Two Groups (x±s)

Lipid Metabolism Indicator	Study Group (n=73)	Control Group (n=67)	t value	95% CI	P value
TC (mmol/L)	5.64±1.49	5.01±1.32	3.332	0.165–1.096	<0.001
TG (mmol/L)	1.89±0.34	1.32±0.43	3.411	0.441–0.699	<0.001
LDL-C (mmol/L)	3.31±0.43	2.12±0.29	4.142	1.069–1.311	<0.001
HDL-C (mmol/L)	1.45±0.21	1.78±0.42	4.347	−0.442--0.219	<0.001

Abbreviations: CI, Confidence interval; TC, Total cholesterol; TG, Triglycerides; LDL-C, Low-density lipoprotein cholesterol; HDL-C, High-density lipoprotein cholesterol.

Table 4 Comparison of Inflammatory Indicators Between Two Groups (x±s)

Inflammatory Indicator	Study Group (n=73)	Control Group (n=67)	t value	95% CI	P value
IL-37 (pg/mL)	45.56±6.02	34.02±3.28	9.332	9.951–13.129	<0.001
IL-18 (pg/mL)	73.57±5.82	60.34±4.84	10.141	11.462–14.998	<0.001

Abbreviations: CI, Confidence interval; IL-37, Interleukin-37; IL-18, Interleukin-18.