Benefits of Combining Antiepileptic Drugs with Vitamin B12 on Redox Balance: Penicillin-Induced Experimental Epilepsy Model

Figures & data

Table 1 Total Oxidant/Antioxidant Status and Oxidative Stress Index Levels of Groups

Characteristics	Group 1 (n=7)	Group 2 (n=7)	Group 3 (n=7)	Group 4 (n=7)	Group 5 (n=7)	p value
TAS, mmol trolox Equiv. / L Median (Q1-Q3)	0.68 (0,58–0,73)	0,56 (0,52–0,66)	0,57 (0,48–0,62)	0,55 (0,39–0,66)	0,77 (0,69–0,80)	0.013 ^a
TOS, μmol H2O2 Equiv. / L Median (Q1-Q3)	222 (86–354)	68 (53–77)	59 (48–95)	36 (31–42)	30 (25–40)	˂0.001 ^b,c
OSI, AU Median (Q1-Q3)	36,5 (10,9–53,0)	10,8 (9,5–14,1)	12,1 (8,9–19,2)	7,2 (5,3–8,8)	4,2 (3,2–5,7)	0.001 ^a,b,c

Notes: Note: Bold values statistically significant at p < 0.05. ^aGroup 3 vs Group 5. ^bGroup 1 vs Group 4. ^cGroup 1 vs Group 5.

Abbreviations: TOS, Total oxidant status; TAS, Total antioxidant status; OSI, Oxidative stress index.

Table 2 Thiol Disulfide Homeostasis Parameters of Groups

Characteristics	Group 1 (n=7)	Group 2 (n=7)	Group 3 (n=7)	Group 4 (n=7)	Group 5 (n=7)	p value
Native Thiol, μmol / L Median (Q1-Q3)	82 (76–91)	77 (68–98)	80 (43–160)	73 (65–89)	121 (82–191)	0.311
Total Thiol, μmol / L Median (Q1-Q3)	208 (192–230)	246 (233–273)	243 (222–306)	218 (211–256)	270 (244–315)	0.017^c
Disulphide, μmol / L Median (Q1-Q3)	64 (56–70)	81 (70–101)	86 (59–101)	78 (65–88)	53 (43–109)	0.287
Reduced Thiol, % Median (Q1-Q3)	39 (36–42)	32 (25–41)	35 (19–48)	33 (28–38)	52 (27–68)	0.507
Oxidized Thiol, % Median (Q1-Q3)	30 (28–31)	33 (29–37)	32 (25–40)	33 (30–35)	23 (15–36)	0.507
ThiolOxidation-Reduction Median (Q1-Q3)	76 (68–86)	107 (70–148)	94 (57–214)	97 (81–128)	44 (23–133)	0.507

Notes: Bold values statistically significant at p < 0.05. ^cGroup 1 vs Group 5.

Data Sharing Statement

The data presented in this study may be requested from the corresponding author on reasonable grounds.