Two grams of sarcosine in schizophrenia – is it too much? A potential role of glutamate-serotonin interaction

Figures & data

Table 1 Psychiatric assessment scores

	Before sarcosine	Sarcosine 2 g	Sarcosine end of 2 g	Sarcosine 1 g
PANSS P	9	9	12	9
PANSS N	22	19	16	17
PANSS G	42	29	34	28
PANSS T	73	57	63	54
Calgary	4	5	4	3
HAMA	7	16	12	9

Notes: The first visit was before the start of sarcosine. The second visit was after 2 weeks of taking the 2 g dose of aminoacid. On the third visit, after a further 2 weeks, the dose was reduced. After a further 2 weeks, on the fourth visit, the patient was taking 1 g of sarcosine.

Abbreviations: PANSS, Positive and Negative Symptoms of Schizophrenia; P, positive; N, negative; G, general psychopathology; T, total score; Calgary, Calgary Scale for Depression in Schizophrenia; HAMA, Hamilton Anxiety Scale.