Roles of Exosomes and Exosomal MicroRNAs in Postoperative Sleep Disturbance

Figures & data

Table 1 Passways and Pathomechanisms of miRNAs in Postoperative Sleep Disturbance

	Expression	Signaling Pathway(s)	Pathomechanism(s)	Reference
miR-26b	Up	Binds to IL-6 mRNA 3ʹUTR to hinder IL-6 transcription	Suppress microglia activation	Kang et al^Citation86
	Up	Inactivates BCL-2-related mitochondrial apoptosis pathway	Neuronal apoptosis	Gao et al^Citation111
miR-188-5p	Up	Increases IL-6mRNA by targeting HNRNPA1	Induce cytokine transcription	Mosakhani et al^Citation87
miR-155	Up	Induces TLR signalling pathway by suppressing c-Maf, SOCS1	Activate inflammation signaling pathway	Surbhi et al^Citation92
miR-146a	Down	Down-regulates NF-κB by repressing IRAK1 and TRAF6	Inflammatory regulation	Nakano et al^Citation93
miR-21	Down	Inhibits TLR4/TNF-α/IL-6R pathway	Suppress neuroinflammatory response	Chen et al^Citation94
miR-23a	Down	Ehances TNF-α and IL-6 secretions	Induce inflammatory response	Chen et al^Citation94
miR-224-5p	Up	Inhibits MALAT1/NLRP3/IL-1β	Reduce microglia activation	Du et al^Citation95
miR-181c	Down	Reduces TLR4/NF-κB/p65 activation	Inflammatory regulation	Fang et al^Citation96
	Down	Promotes neurons remodeling by targeting TRIM2	Dendritic morphogenesis	Fang et al^Citation96
miR-132	Down	Enhances synaptic growth by down-regulating p250GAP protein	Synaptic plasticity	Xu et al^Citation99
miR-134	Down	Promotes dendrite growth by inhibiting Pumilio2	Drentritic growth	Fiore et al^Citation100
miR-206	Up	Induces BDNF level	Neurotrophic factor	Zhao et al^Citation103
miR-124	Down	Promotes the hypomethylation of BACE1 protein	Aβ production	Zhang et al^Citation107
miR-195	Down	Regulats APP and BACE1 expression at the post-transcriptional level	Aβ aggregation	Sun et al^Citation108
miR-207	Down	Modulates neurotrophins signaling	Synaptic plasticity	Gao et al^Citation111

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Gao H, Han Z, Huang S, et al. Intermittent hypoxia caused cognitive dysfunction relate to miRNAs dysregulation in hippocampus. Behav Brain Res. 2017;335:80–87. doi:10.1016/j.bbr.2017.06.025

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Mosakhani N, Sarhadi V, Panula P, et al. Narcolepsy patients’ blood-based miRNA expression profiling: miRNAexpression differences with Pandemrix vaccination. Acta Neurol Scand. 2017;136(5):462–469. doi:10.1111/ane.12749

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Surbhi, Borniger JC, Russart KLG, et al. miR-155 deletion modulates lipopolysaccharide-induced sleep in female mice. Chronobiol Int. 2019;36(2):188–202. doi:10.1080/07420528.2018.1525617

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Nakano M, Kubota K, Kobayashi E, et al. Bone marrow‑derived mesenchymal stem cells improve cognitive impairment in an Alzheimer’s disease model by increasing the expression of microRNA‑146a in hippocampus. Sci Rep. 2020;10(1):10772. doi:10.1038/s41598-020-67460-1

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Chen Y-C, Hsu P-Y, Su M-C, et al. miR-21-5p under-expression in patients with obstructive sleep apnea modulates intermittent hypoxia with re-oxygenation-induced-cell apoptosis and cytotoxicity by targeting pro-inflammatory TNF-α-TLR4 signaling. Int J Mol Sci. 2020;21(3):999. doi:10.3390/ijms21030999

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Du P, Wang J, Han Y, Feng J. Blocking the LncRNA MALAT1/miR-224-5p/NLRP3 axis inhibits the hippocampal inflammatory response in T2DM with OSA. Front Cell Neurosci. 2020;14:97. doi:10.3389/fncel.2020.00097

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Fang C, Qian L, Min G, et al. MicroRNA-181c ameliorates cognitive impairment induced by chronic cerebral hypoperfusion in rats. Mol Neurobiol. 2017;54(10):8370–8385. doi:10.1007/s12035-016-0268-6

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Nan X, Ang-Di L, Li-Li J, et al. miR-132 regulates the expression of synaptic proteins in APP/PS1 transgenic mice through C1q. Eur J Histochem. 2019;63(2):3008. doi:10.4081/ejh.2019.3008

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Fiore R, Khudayberdiev S, Christensen M, et al. Mef2-mediated transcription of the miR379–410 cluster regulates activity-dependent dendritogenesis by fine-tuning Pumilio2 protein levels. EMBO J. 2009;28(6):697–710. doi:10.1038/emboj.2009.10

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Zhao H, Yunjun L, Chen L, et al. HucMSCs-derived miR-206-knockdown exosomes contribute to neuroprotection in subarachnoid hemorrhage induced early brain injury by targeting BDNF. Neuroscience. 2019;417:11–23. doi:10.1016/j.neuroscience.2019.07.051

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Zhang X, Huang X, Fang C, et al. miR-124 regulates the expression of BACE1 in the hippocampus under chronic cerebral hypoperfusion. Mol Neurobiol. 2017;54(4):2498–2506. doi:10.1007/s12035-016-9845-y

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Sun JA-H, Che H, Zhang R, et al. MicroRNA-195 protects against dementia induced by chronic brain hypoperfusion via its anti-amyloidogenic effect in rats. J Neurosci. 2013;33(9):3989–4001. doi:10.1523/JNEUROSCI.1997-12.2013

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