Class II Human Leukocyte Antigen (HLA) and Susceptibility to Polypoidal Choroidal Vasculopathy in Afro-Caribbean Descent

Figures & data

Table 1 Frequency and Measure of DRB1 Allele Association

			PCV vs Controls
HLA Alleles	PCV n=47 (%)	Controls n=457 (%)	OR	95% CI	X^2	p	cp<0.004
DRB1*01	8 (6.30)	84 (9.42)	0.65	[0.31;1.38]	0.74	0.32	ns
DRB1*02	0 (0)	1 (0.11)	0	–	–	–	–
DRB1*03	25 (19.69)	105 (11.77)	1.84	[1.14;2.98]	6.26	0.016	ns
DRB1*04	10 (7.87)	78 (8.74)	0.89	[0.45;1.77]	0.11	0.866	ns
DRB1*07	4 (3.15)	75 (8.41)	0.51	[0.18;1.43]	1.73	0.225	ns
DRB1*08	8 (6.30)	51 (5.72)	1.11	[0.51;2.4]	0.07	0.838	ns
DRB1*09	3 (2.36)	29 (3.25)	0.72	[0.22;2.4]	0.24	0.788	ns
DRB1*10	0 (0)	21 (2.35)	–	–	–	–	–
DRB1*11	16 (12.60)	112 (12.56)	1	[0.57;1.75]	0	1	ns
DRB1*12	2 (1.57)	26 (2.91)	0.53	[0.12;2.26]	0.75	0.564	ns
DRB1*13	33 (25.98)	132 (14.80)	2.02	[1.3;3.13]	10.25	0.003	< 0.004
DRB1*14	4 (3.15)	34 (3.81)	0.82	[0.29;2.35]	0.14	1	ns
DRB1*15	13 (10.24)	127 (14.24)	0.69	[0.38;1.26]	1.5	0.27	ns
DRB1*16	1 (0.79)	17 (1.91)	0.41	[0.05;3.11]	0.8	0.715	ns

Abbreviations: HLA, human leucocyte antigen; PCV, polypoidal choroidal vasculopathy; OR, odds ratio; CI, confidence interval; p, p-value; cp, p-value of Bonferroni correction; ns, not significant.

Table 2 Frequency and Measure of DQB1 Allele Association

			PCV vs Controls
HLA Alleles	PCV n=32 (%)	Controls n=457 (%)	OR	95% CI	X^2	p	cp<0.006
DQB1*01	1 (0.95)	0 (0.00)	0	–	–	–	–
DQB1*02	16 (15.24)	42 (21.21)	0.67	[0.36;1.26]	1.58	0.224	ns
DQB1*03	22 (20.95)	46 (23.23)	0.88	[0.5;1.56]	0.2	0.772	ns
DQB1*04	15 (14.29)	9 (4.55)	3.5	[1.48;8.3]	8.93	0.006	< 0.006
DQB1*05	19 (18.10)	43 (21.72)	0.8	[0.44;1.46]	0.55	0.55	ns
DQB1*06	30 (28.57)	57 (28.79)	0.99	[0.59;1.67]	0	1	ns
DQB1*08	2 (1.90)	0 (0.00)	–	–	–	–	ns
DQB1*13	0 (0.00)	1 (0.51)	–	–	–	–	ns

Abbreviations: HLA, human leucocyte antigen; PCV, polypoidal choroidal vasculopathy; OR, odds ratio; CI, confidence interval; p, p-value; cp, p-value of Bonferroni correction; ns, not significant.