Preliminary Surgical Outcomes of a Trimmed-Plate Aurolab Aqueous Drainage Implant (AADI) in Eyes at High Risk of Hypotony

Figures & data

Figure 1 The trimmed-plate AADI is shown in relation to the standard plate size. The trimmed-plate AADI implant is achieved by trimming the two lateral wings of the AADI.

Table 1 Baseline Characteristics of Eyes/Persons in the Trimmed-Plate AADI, Standard AADI and Baerveldt-250 Groups*

Characteristic	Trimmed-AADI (19 Eyes)	Standard AADI (36 Eyes)	BGI-250 (14 Eyes)	P-value
Mean±SD age, years	25.1± 22.9	34.2± 23.8	34.0 ± 26.7	0.384
Sex, n (%)				0.537
Male	13 (68.4)	23 (63.9)	7 (50)
Female	6 (31.6)	13 (36.1)	7 (50)
Eye, n (%)				0.295
OD	12 (63.2)	19 (52.8)	5 (35.7)
OS	7 (36.8)	17 (47.2)	9 (64.3)
Lens status, n(%)				0.128
Phakic	6 (31.6)	20 (55.6)	6 (42.9)
Pseudophakic	9 (47.4)	14 (38.9)	4 (28.6)
Aphakic	4 (21.1)	2 (5.6)	4 (28.6)
Baseline visual acuity, n(%)				0.677
20/20-20/200	4 (36.4)	16 (51.6)	7 (50)
<20/200	7 (63.6)	15 (48.4)	7 (50)
Diagnosis, n(%)				0.030
Primary open angle glaucoma	1 (5.2)	9 (25)	0 (0)
Secondary open angle glaucoma	7 (36.8)	11 (30.6)	7 (50)
Primary closed angle glaucoma	1 (5.2)	2 (5.6)	0 (0)
Secondary angle closure glaucoma	3 (15.8)	1 (2.8)	3 (21.4)
Congenital glaucoma	6 (31.6)	10 (27.8)	3 (21.4)
Neovascular glaucoma	1 (5.2)	3 (8.3)	1 (7.1)
Previous glaucoma surgery				…
Trabeculectomy	4 (21.1)	12 (33.3)	2 (14.3)
DS	1 (5.3)	6 (16.7)	0 (0)
AGV	9 (47.4)	15 (41.7)	4 (28.6)
Baerveldt tube	0 (0)	1 (2.8)	0 (0)
ECP	1 (5.3)	0 (0)	0 (0)
CPC	5 (26.3)	1 (2.1)	0 (0)
Revision of glaucoma surgery	0 (0)	0 (0)	1 (7.1)
Previous other surgeries, n(%)				…
Cataract	7 (36.8)	11 (30.6)	6 (42.9)
ECCE	0 (0)	0 (0)	1 (7.1)
PPV	4 (21.1)	7 (19.4)	2 (14.3)
Corneal graft	2 (10.5)	2 (5.6)	2 (14.3)
Primary repair	0 (0)	2 (5.6)	0 (0)
Other	6 (31.6)	5 (13.9)	1 (7.1)
None	2 (10.5)	3 (8.3)	4 (28.6)

Note: *Only one eye per patient was eligible and included in the study.

Figure 2 Mean IOP for trimmed-plate AADI, standard AADI and the Baerveldt-250 groups over time.

Figure 3 Kaplan-Meier plots depicting cumulative surgical success over time for the trimmed-plate AADI, standard AADI and the Baerveldt-250 groups.

Table 2 Intra- and Post-Operative Complications in the Three Treatment Groups

Variable	Trimmed-AADI (19 Eyes)	Standard AADI (36 Eyes)	BGI-250 (14 Eyes)
Complication, n (%)
Yes	7 (36.8)	3 (8.3)	5 (35.7)
No	12 (63.2)	33 (91.7)	9 (64.3)
Complication type, n(%)	Trimmed-AADI (7 Eyes)	AADI (3 Eyes)	BGI-250 (5 Eyes)
Tube erosion	3 (42.9)	2 (66.6)	2 (40)
Tube Occlusion	1 (14.3)	0 (0)	1 (20)
Tube corneal touch	0 (0)	0 (0)	1 (20)
Choroidal effusion	4 (57.1)	1 (33.3)	0 (0)
Endophthalmitis	0 (0)	0 (0)	1 (20)
Shallow AC	0 (0)	0 (0)	1 (20)

Table 3 Subsequent Surgeries

Subsequent Surgery	Trimmed-AADI (19 Eyes)	Standard AADI (36 Eyes)	BGI-250 (14 Eyes)
CPC	0 (0)	3 (8.3)	0 (0)
Tube revision	6 (31.6)	4 (11.1)	2 (14.3)
Trab	1 (5.3)	0 (0)	1 (7.1)
Tube removal	3 (15.8)	1 (2.8)	0 (0)
None	10 (52.6)	29 (80.6)	12 (85.7)