Absence of Herpesvirus DNA in Aqueous Humor from Asymptomatic Subjects

Figures & data

Table 1 Previous Publications with Herpes Virus PCR-Analysis of Aqueous Humor in Asymptomatic Patients Taken in Conjunction with Intraocular Surgery

	PCR	Sample Size	Results
Rothova 2008^Citation10	HSV1, HSV2, VZV, CMV, (toxoplasma)	20	Negative
Yamamoto 1996^Citation14	HSV, VZV, CMV	10	Negative
Laaks 2015^Citation15	HSV1, HSV2, VZV CMV, EBV, HHV-6	57	Negative
Pendergast 2000^Citation16	HSV1, HSV2, VZV, CMV, EBV	35	Negative
Kerochana 2018^Citation17	HSV1, HSV2, VZV, CMV, EBV	66	Negative
Cimino 2013^Citation18	HSV, VZV, CMV, (rubella virus)	27	Positive: 1 CMV, 1 HSV

Abbreviations: CMV, cytomegalovirus; EBV, Epstein Barr virus; HHV-6, human herpes virus 6; HSV, herpes simplex virus; PCR, polymerase chain reaction; VZV, varicella zoster virus.

Rothova A, de Boer JH, Ten Dam-van Loon NH, et al. Usefulness of aqueous humor analysis for the diagnosis of posterior uveitis. Ophthalmology. 2008;115(2):306–311. doi:10.1016/j.ophtha.2007.05.014

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Yamamoto S, Pavan-Langston D, Kinoshita S, Nishida K, Shimomura Y, Tano Y. Detecting herpesvirus DNA in uveitis using the polymerase chain reaction. Br J Ophthalmol. 1996;80(5):465–468. doi:10.1136/bjo.80.5.465

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Laaks D, Smit DP, Harvey J. Polymerase chain reaction to search for Herpes viruses in uveitic and healthy eyes: a South African perspective. Afr Health Sci. 2015;15(3):748–754. doi:10.4314/ahs.v15i3.7

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Pendergast SD, Werner J, Drevon A, Wiedbrauk DL. Absence of herpesvirus DNA by polymerase chain reaction in ocular fluids obtained from immunocompetent patients. Retina. 2000;20(4):389–393. doi:10.1097/00006982-200007000-00012

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Keorochana N, Intaraprasong W, Choontanom R. Herpesviridae prevalence in aqueous humor using PCR. Clin Ophthalmol. 2018;12:1707–1711. doi:10.2147/OPTH.S174694

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Cimino L, Aldigeri R, Parmeggiani M, et al. Searching for viral antibodies and genome in intraocular fluids of patients with Fuchs uveitis and non-infectious uveitis. Graefes Arch Clin Exp Ophthalmol. 2013;251(6):1607–1612. doi:10.1007/s00417-013-2287-6

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