Absence of Herpesvirus DNA in Aqueous Humor from Asymptomatic Subjects

Joanna von Hofsten1 Department of Clinical Neuroscience, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, SE-405 30, Sweden;2 Department of Ophthalmology, Halland Hospital Halmstad, Halmstad, SE- 301 85, SwedenCorrespondence[email protected]

https://orcid.org/0000-0002-9352-8183

Tomas Bergström3 Department of Infectious Diseases, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, SE-413 46, Sweden

Madeleine Zetterberg1 Department of Clinical Neuroscience, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, SE-405 30, Sweden;4 Department of Ophthalmology, Sahlgrenska University Hospital, Mölndal, SE-431 30, Sweden

Pages 959-962 | Published online: 30 Mar 2022

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Grose C. Pangaea and the out-of-Africa model of varicella-zoster virus evolution and phylogeography. J Virol. 2012;86(18):9558–9565. doi:10.1128/JVI.00357-12
PubMed Web of Science ®Google Scholar
Depledge DP, Kundu S, Jensen NJ, et al. Deep sequencing of viral genomes provides insight into the evolution and pathogenesis of varicella zoster virus and its vaccine in humans. Mol Biol Evol. 2014;31(2):397–409. doi:10.1093/molbev/mst210
PubMed Web of Science ®Google Scholar
Wertheim JO, Smith MD, Smith DM, Scheffler K, Kosakovsky Pond SL. Evolutionary origins of human herpes simplex viruses 1 and 2. Mol Biol Evol. 2014;31(9):2356–2364. doi:10.1093/molbev/msu185
PubMed Web of Science ®Google Scholar
Richter ER, Dias JK, Gilbert JE 2nd, Atherton SS. Distribution of herpes simplex virus type 1 and varicella zoster virus in ganglia of the human head and neck. J Infect Dis. 2009;200(12):1901–1906. doi:10.1086/648474
PubMed Web of Science ®Google Scholar
von Hofsten J, Ringlander J, Norberg P, et al. Deep sequencing of varicella-zoster virus in aqueous humor from a patient with acute retinal necrosis presenting with acute glaucoma. Open Forum Infect Dis. 2020;7(6):ofaa198. doi:10.1093/ofid/ofaa198
PubMed Web of Science ®Google Scholar
Higaki S, Fukuda M, Shimomura Y. Virological and molecular biological evidence supporting herpes simplex virus type 1 corneal latency. Jpn J Ophthalmol. 2015;59(2):131–134. doi:10.1007/s10384-014-0369-6
PubMed Web of Science ®Google Scholar
Kaufman HE, Azcuy AM, Varnell ED, Sloop GD, Thompson HW, Hill JM. HSV-1 DNA in tears and saliva of normal adults. Invest Ophthalmol Vis Sci. 2005;46(1):241–247. doi:10.1167/iovs.04-0614
PubMed Web of Science ®Google Scholar
Ramchandani M, Kong M, Tronstein E, et al. Herpes simplex virus type 1 shedding in tears and nasal and oral mucosa of healthy adults. Sex Transm Dis. 2016;43(12):756–760. doi:10.1097/OLQ.0000000000000522
PubMed Web of Science ®Google Scholar
Mehta SK, Cohrs RJ, Forghani B, Zerbe G, Gilden DH, Pierson DL. Stress-induced subclinical reactivation of varicella zoster virus in astronauts. J Med Virol. 2004;72(1):174–179. doi:10.1002/jmv.10555
PubMed Web of Science ®Google Scholar
Rothova A, de Boer JH, Ten Dam-van Loon NH, et al. Usefulness of aqueous humor analysis for the diagnosis of posterior uveitis. Ophthalmology. 2008;115(2):306–311. doi:10.1016/j.ophtha.2007.05.014
PubMed Web of Science ®Google Scholar
Namvar L, Olofsson S, Bergstrom T, Lindh M. Detection and typing of herpes simplex virus (HSV) in mucocutaneous samples by TaqMan PCR targeting a gB segment homologous for HSV types 1 and 2. J Clin Microbiol. 2005;43(5):2058–2064. doi:10.1128/JCM.43.5.2058-2064.2005
PubMed Web of Science ®Google Scholar
Persson A, Bergstrom T, Lindh M, Namvar L, Studahl M. Varicella-zoster virus CNS disease–viral load, clinical manifestations and sequels. J Clin Virol. 2009;46(3):249–253. doi:10.1016/j.jcv.2009.07.014
PubMed Web of Science ®Google Scholar
Koizumi N, Yamasaki K, Kawasaki S, et al. Cytomegalovirus in aqueous humor from an eye with corneal endotheliitis. Am J Ophthalmol. 2006;141(3):564–565. doi:10.1016/j.ajo.2005.09.021
PubMed Web of Science ®Google Scholar
Yamamoto S, Pavan-Langston D, Kinoshita S, Nishida K, Shimomura Y, Tano Y. Detecting herpesvirus DNA in uveitis using the polymerase chain reaction. Br J Ophthalmol. 1996;80(5):465–468. doi:10.1136/bjo.80.5.465
PubMed Web of Science ®Google Scholar
Laaks D, Smit DP, Harvey J. Polymerase chain reaction to search for Herpes viruses in uveitic and healthy eyes: a South African perspective. Afr Health Sci. 2015;15(3):748–754. doi:10.4314/ahs.v15i3.7
PubMed Web of Science ®Google Scholar
Pendergast SD, Werner J, Drevon A, Wiedbrauk DL. Absence of herpesvirus DNA by polymerase chain reaction in ocular fluids obtained from immunocompetent patients. Retina. 2000;20(4):389–393. doi:10.1097/00006982-200007000-00012
PubMed Web of Science ®Google Scholar
Keorochana N, Intaraprasong W, Choontanom R. Herpesviridae prevalence in aqueous humor using PCR. Clin Ophthalmol. 2018;12:1707–1711. doi:10.2147/OPTH.S174694
PubMed Web of Science ®Google Scholar
Cimino L, Aldigeri R, Parmeggiani M, et al. Searching for viral antibodies and genome in intraocular fluids of patients with Fuchs uveitis and non-infectious uveitis. Graefes Arch Clin Exp Ophthalmol. 2013;251(6):1607–1612. doi:10.1007/s00417-013-2287-6
PubMed Web of Science ®Google Scholar
Kumar M, Hill JM, Clement C, Varnell ED, Thompson HW, Kaufman HE. A double-blind placebo-controlled study to evaluate valacyclovir alone and with aspirin for asymptomatic HSV-1 DNA shedding in human tears and saliva. Invest Ophthalmol Vis Sci. 2009;50(12):5601–5608. doi:10.1167/iovs.09-3729
PubMed Web of Science ®Google Scholar
Okinaga S. Shedding of herpes simplex virus type 1 into tears and saliva in healthy Japanese adults. Kurume Med J. 2000;47(4):273–277. doi:10.2739/kurumemedj.47.273
PubMedGoogle Scholar
Chee SP, Bacsal K, Jap A, Se-thoe SY, Cheng CL, Tan BH. Corneal endotheliitis associated with evidence of cytomegalovirus infection. Ophthalmology. 2007;114(4):798–803. doi:10.1016/j.ophtha.2006.07.057
PubMed Web of Science ®Google Scholar
Martin C, Enbom M, Soderstrom M, et al. Absence of seven human herpesviruses, including HHV-6, by polymerase chain reaction in CSF and blood from patients with multiple sclerosis and optic neuritis. Acta Neurol Scand. 1997;95(5):280–283. doi:10.1111/j.1600-0404.1997.tb00210.x
PubMed Web of Science ®Google Scholar

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