Single nucleotide polymorphisms in the mitochondrial displacement loop and age at onset of non-Hodgkin lymphoma

Figures & data

Figure 1 Comparison of age at onset for NHL patients according to (A) sex and (B) TNM classification with Kaplan–Meier methods.

Abbreviations: NHL, non-Hodgkin lymphoma; TNM, tumor node metastasis.

Table 1 Onset age distribution in NHL patients

Age	Cases (N)
	Male	Female
≤30	20	5
30~40	5	11
41~50	16	12
51~60	20	10
61~70	10	10
>70	10	4

Abbreviation: NHL, non-Hodgkin lymphoma.

Table 2 Clinical characteristics and their association with onset age in NHL patients

Characteristics	Cases (N)	P-value
Sex		0.443
Male	81
Female	52
TNM classification		0.031
I–II	43
III–IV	90

Abbreviations: NHL, non-Hodgkin lymphoma; TNM, tumor node metastasis.

Figure 2 Comparison of age at onset for NHL patients, according to the genotype of nucleotides 146, 151, 194, 16261, 315, 523, and 525 in the mitochondrial D-loop, using the Kaplan–Meier method.

Abbreviations: D-loop, displacement loop; NHL, non-Hodgkin lymphoma.

Table 3 Polymorphic sites of the D-loop and their association with onset age in NHL patients

Polymorphic sites	Cases (N)	P-value
146		0.044
C	13
T	120
151		0.006
T	7
C	126
194		0.082
T	7
C	126
16261		0.083
T	9
C	124
315		0.024
C	6
C inserta	127
523		0.001
Del	43
A	90
525		0.000
Del	46
C	87

Note:

a Including C and CC insertion.

Abbreviations: D-loop, displacement loop; NHL, non-Hodgkin lymphoma.

Table 4 Multivariate analysis of predictors associated with age at onset of NHL patients

Factors	Relative risk	95% CI	P-value
16261	0.714	0.329–1.548	0.393
146	0.403	0.182–0.895	0.026
151	0.378	0.165–0.868	0.022
194	0.515	0.192–1.381	0.187
315–316	3.554	1.344–9.400	0.011
523	1.330	0.392–4.515	0.648
525	0.400	0.121–1.322	0.133
TNM classification	1.601	0.927–2.764	0.091

Abbreviations: CI, confidence interval; NHL, non-Hodgkin lymphoma; TNM, tumor node metastasis.