Significance of preoperative C-reactive protein as a parameter in patients with small cell carcinoma of the esophagus

Figures & data

Table 1 The baseline characteristics of 43 patients with SCCE

	Cases (n, %)
Age (mean ± SD, years)	58.7 ± 7.8
Gender
Female	13 (30.2)
Male	30 (69.8)
Tumor size (mean ± SD, cm)	4.1 ± 1.9
Tumor location
Upper	2 (4.7)
Middle	23 (53.5)
Lower	18 (41.8)
Depth of invasion
T1	9 (20.9)
T2	10 (23.3)
T3	22 (51.1)
T4	2 (4.7)
Nodal metastasis
N0	15 (34.9)
N1	13 (30.2)
N2	8 (18.6)
N3	7 (16.3)

Abbreviations: SCCE, small cell carcinoma of the esophagus; SD, standard deviation.

Table 2 The characteristics between patients with CRP ≤10 mg/L and >10 mg/L

	CRP ≤10 mg/L (n, %)	CRP >10 mg/L (n, %)	P-value
Age (years)			0.965
≤60	15 (55.6)	9 (56.3)
>60	12 (44.4)	7 (43.7)
Gender			0.086
Female	11 (40.7)	2 (12.5)
Male	16 (59.3)	14 (87.5)
Tumor length (cm)			0.278
≤3.0	13 (48.1)	5 (31.3)
>3.0	14 (51.9)	11 (68.7)
Tumor location			0.141
Upper/middle	18 (66.7)	7 (43.7)
Lower	9 (33.3)	9 (56.3)
Vessel involvement			0.719
Negative	20 (74.1)	13 (81.3)
Positive	7 (25.9)	3 (18.7)
Depth of invasion			0.018
T1–2	15 (55.6)	3 (18.7)
T3–4a	12 (44.4)	13 (81.3)
Nodal metastasis			0.018
Negative	13 (48.1)	2 (12.5)
Positive	14 (51.9)	14 (87.5)

Abbreviation: CRP, C-reactive protein.

Figure 1 Patients with CRP ≤10 mg/L had a significantly better 5-year overall survival rate than patients with CRP >10 mg/L (25.9% vs 6.3%, P = 0.004).

Abbreviation: CRP, C-reactive protein.

Table 3 Univariate and multivariate analyses of overall survival in SCCE patients

	Survival (%)	Chi-square	P-value	HR (95% CI)	P-value
Age (years)		0.686	0.408
≤60	16.7
>60	21.1
Gender		1.841	0.175
Female	38.5
Male	10.0
Tumor length (cm)		6.846	0.009		0.582
≤3	33.3			1.000
>3	8.0			1.267 (0.546–2.937)
Tumor location		0.024	0.877
Upper/middle	20.0
Lower	16.7
CRP (mg/L)		8.115	0.004		0.028
≤10	25.9			1.000
>10	6.3			2.756 (1.115–6.813)
Vessel involvement		1.068	0.301
Negative	21.2
Positive	10.0
Depth of invasion		7.433	0.006		0.232
T1–2	33.3			1.000
T3–4a	8.0			1.716 (0.708–4.161)
Nodal metastasis		9.687	0.002		0.189
Negative	40.0			1.000
Positive	7.1			1.891 (0.731–4.892)
Chemoradiotherapy		5.577	0.018		0.004
No	5.9			1.000
Yes	26.9			0.294 (0.129–0.673)

Abbreviations: CI, confidence interval; CRP, C-reactive protein; HR, hazard ratio; SCCE, small cell carcinoma of the esophagus.