Intraoperative radiotherapy in stage IIB adenocarcinoma of the uterine cervix: a retrospective study

Figures & data

Table 1 Patient characteristics

Characteristics	N
Median age (range)	46.2 years (21–74)
Histologic subtype
Adenocarcinoma	16
Adenosquamous carcinoma	10
Other subtypes of adenocarcinoma	1
Treatment
EBRT + IOERT	4
EBRT + IOERT + CT (4–6 cycles)	17
EBRT + IOERT + CT (2 cycles)	6
Lymph node status
Positive	2
Negative	9
Unknown	16
Margins
Positive	2
Negative	19
Close	6

Abbreviations: CT, computed tomography; EBRT, external beam radiation therapy; IOERT, intraoperative electron beam radiation therapy.

Figure 1 Survival analysis in advanced adenocarcinoma of the uterine cervix after IOERT.

Notes: (A) Overall survival curve stratified for EBRT + IOERT + CT (4–6 cycles) versus EBRT + IOERT + CT (≤2 cycles) (P>0.05). (B) Disease-free survival curve stratified for EBRT + IOERT + CT (4–6 cycles) versus EBRT + IOERT + CT (≤2 cycles) (P>0.05). (C) Overall survival curve stratified for adenocarcinoma versus decreased adenosquamous carcinoma (P<0.05). (D) Disease-free survival curve stratified for adenocarcinoma versus decreased adenosquamous carcinoma (P<0.05).
Abbreviations: CT, computed tomography; Cum, cumulative; EBRT, external beam radiation therapy; IOERT, intraoperative electron beam radiation therapy.

Table 2 Five-year disease-free and overall survival rates stratified by patient group

	Treatment		P-value	Histologic subtype		P-value
	EBRT + IOERT + CT (4–6 cycles)	EBRT + IOERT + CT (<2 cycles)		Adenocarcinoma	Adenosquamous carcinoma
Overall survival	76.4% (13/17)	80% (8/10)	0.832	87.5% (15/16)	70% (6/10)	0.034
Disease-free survival	70.6% (12/17)	70% (7/10)	0.852	81.3% (14/16)	0% (5/10)	0.031

Abbreviations: CT, computed tomography; EBRT, external beam radiation therapy; IOERT, intraoperative electron beam radiation therapy.