Individualized Drug Repositioning For Rheumatoid Arthritis Using Weighted Kolmogorov–Smirnov Algorithm

Figures & data

Table 1 The Differential Pathways In Rheumatoid Arthritis Based On The Individualized Pathway Aberrance Score

Category	Pathway	p	Altered Frequency
Hsa00520	Amino sugar and nucleotide sugar metabolism	0.019	11
Hsa04260	Cardiac muscle contraction	0.021	14
Hsa04141	Protein processing in endoplasmic reticulum	0.024	10
Hsa05146	Amoebiasis	0.047	12

Table 2 The Candidate Therapeutic Drugs Of Rheumatoid Arthritis

Candidate Drug	Mean ES	Rank Score	CAS Number	Stage	Current Drug Indication
Suloctidil	0.245	0.783	54063-56-8	Withdrawn	Vasodilator
Prenylamine	0.245	0.783	390-64-7	Withdrawn	Vasodilator
Mebendazole	0.253	0.780	31431-39-7	Approved	Anthelmintic
Danazol	0.247	0.778	17230-88-5	Approved	Endometriosis
Piperlongumine	0.249	0.775	20069-09-4	Investigated	Anticancer
Harmine	0.254	0.773	442-51-3	Investigated	Osteogenic differentiation
Celecoxib	0.247	0.770	169590-42-5	Approved	Arthritis
Sanguinarine	0.246	0.769	2447-54-3	Investigated	Anticancer
Parthenolide	0.250	0.767	20554-84-1	Investigated	Anti-inflammatory

Abbreviation: ES, enrichment score.

Table 3 The Good Mimics Of Rheumatoid Arthritis

Candidate Drug	Mean ES	Rank Score	CAS Number	Stage	Current Drug Indication
Camptothecin	0.608	0.088	2114454	Experimental	Anticancer
Doxorubicin	0.583	0.104	23214-92-8	Approved	Anticancer
Daunorubicin	0.582	0.132	20830-81-3	Approved	Anticancer
Ampicillin	0.531	0.221	69-53-4	Approved	Anti-infection
Cloxacillin	0.518	0.241	61-72-3	Approved	Anti-infection
Streptomycin	0.500	0.271	57-92-1	Approved	Anti-infection
Cortisone	0.501	0.271	53-06-5	Approved	Anti-inflammatory
Estradiol	0.499	0.271	50-28-2	Approved	Estrogen deficiency
Mitoxantrone	0.487	0.278	65271-80-9	Approved	Anticancer

Abbreviation: ES, enrichment score.