Genome-Wide Identification of m6A-Associated Single-Nucleotide Polymorphisms in Colorectal Cancer

Figures & data

Table 1 Rs112126539 (in IGF2BP1) Could Be a CRC-Associated m6A-SNP

SNP ID	Chr	Position	m6A_ID	Gene	Confidence_level	Gene_region	Modification_function	Pvalue
rs112126539	17	49050005	RMVar_ID_1070422	IGF2BP1	Prediction:(Low)	3ʹUTR	Loss	0.018

Figure 1 Flow chart of study design and analysis.

Figure 2 Manhattan plot of genome-wide identified CRC-associated m6A-SNPs (A) and 98 CRC-associated m6A-SNPs showed eQTL signals displaying a unique distribution pattern (B).

Table 2 Three Genes of the m6A-SNPs (rs178184, rs35782901, rs60571683) Were Differentially Expressed Between Controls and CRC in at Least One Data Set

SNP ID	Chr	Position	m6A_ID	Gene	DEG	eQTL	Confidence_Level	Gene_Region	Modification_Function
rs178184	14	26509987	RMVar_ID_684700	NOVA1	Yes	Yes	m6A-Label-seq:(High)	Intron	Loss
rs35782901	5	148629028	RMVar_ID_1344219	HTR4	Yes	Yes	Prediction:(Low)	Intron	Gain
rs60571683	12	20916115	RMVar_ID_945462	SLCO1B3	Yes	Yes	Prediction:(Low)	CDS	Loss

Figure 3 Expression levels of selected genes were displayed among controls and CRC of GSE32323, GSE21510, and GSE89076 datasets.