Pharmacogenomics and Personalized Medicine, Volume 14, Issue (2021)

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Pharmacogenomics and Personalized Medicine, Volume 14, Issue (2021)

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Original Research

Article
Association of CETP Gene Variants with Atherogenic Dyslipidemia Among Thai Patients Treated with Statin
Pornpen Srisawasdi, Punyanuch Rodcharoen, Somlak Vanavanan, Anchalee Chittamma, Chonlaphat Sukasem, Chalitpon Na nakorn, Charungthai Dejthevaporn & Martin H Kroll
Pages: 1-13
Published online: 17 Nov 2022
AbstractforAssociation of CETP Gene Variants with Atherogenic Dyslipidemia Among Thai Patients Treated with Statin | Full Text | References | PDF (672.7 KB) | EPUB
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Open Access
Article
Identification of Four Genes as Prognosis Signatures in Lung Adenocarcinoma Microenvironment
Yan Yao, Tingting Zhang, Lingyu Qi, Ruijuan Liu, Gongxi Liu, Jie Li & Changgang Sun
Pages: 15-26
Published online: 17 Nov 2022
AbstractforIdentification of Four Genes as Prognosis Signatures in Lung Adenocarcinoma Microenvironment | Full Text | References | PDF (9.7 MB) | EPUB
  • 102 Views
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Open Access
Article
Mitochondrial DNA in Fresh versus Frozen Embryo Culture Media of Polycystic Ovarian Syndrome Patients Undergoing Invitro Fertilization: A Possible Predictive Marker of a Successful Pregnancy
Ghadir A Sayed, Hussein A Al-Sawaf, Ahmed H Al-Sawaf, Mohamed Saeid, Ahmed Maged & Iman Hassan Ibrahim
Pages: 27-38
Published online: 17 Nov 2022
AbstractforMitochondrial DNA in Fresh versus Frozen Embryo Culture Media of Polycystic Ovarian Syndrome Patients Undergoing Invitro Fertilization: A Possible Predictive Marker of a Successful Pregnancy | Full Text | References | PDF (2.9 MB) | EPUB
  • 153 Views
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Open Access
Article
The Prognostic Value of DNA Methylation, Post-Translational Modifications and Correlated with Immune Infiltrates in Gynecologic Cancers
Chunliang Shang, Yuan Li, Zhangxin Wu, Qin Han, Yuan Zhu, Tianhui He & Hongyan Guo
Pages: 39-53
Published online: 17 Nov 2022
AbstractforThe Prognostic Value of DNA Methylation, Post-Translational Modifications and Correlated with Immune Infiltrates in Gynecologic Cancers | Full Text | References | PDF (25.8 MB) | EPUB
  • 133 Views
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Open Access
Article
Genetic Variants of the MIF Gene and Susceptibility of Rectal Cancer
Dongyu Chuo, Dapeng Lin, Mingdi Yin & Yuze Chen
Pages: 55-60
Published online: 17 Nov 2022
AbstractforGenetic Variants of the MIF Gene and Susceptibility of Rectal Cancer | Full Text | References | PDF (1.1 MB) | EPUB
  • 90 Views
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Open Access

Review

Review Article
Review on Databases and Bioinformatic Approaches on Pharmacogenomics of Adverse Drug Reactions
Hang Tong, Nga V T Phan, Thanh T Nguyen, Dinh V Nguyen, Nam S Vo & Ly Le
Pages: 61-75
Published online: 17 Nov 2022
AbstractforReview on Databases and Bioinformatic Approaches on Pharmacogenomics of Adverse Drug Reactions | Full Text | References | PDF (1.2 MB) | EPUB
  • 620 Views
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Open Access

Original Research

Article
Genetic Interaction of H19 and TGFBR1 Polymorphisms with Risk of Epilepsy in a Chinese Population
Zhaoshi Zheng, Yayun Yan, Qi Guo, Libo Wang, Xuemei Han & Songyan Liu
Pages: 77-86
Published online: 17 Nov 2022
AbstractforGenetic Interaction of H19 and TGFBR1 Polymorphisms with Risk of Epilepsy in a Chinese Population | Full Text | References | PDF (1.9 MB) | EPUB
  • 108 Views
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Open Access
Article
High LARGE1 Expression May Predict Benefit from Adjuvant Chemotherapy in Resected Non-Small-Cell Lung Cancer
Yu Liu, Shirui Huang, Mengjiao Kuang, Huiyan Wang & Qipeng Xie
Pages: 87-99
Published online: 17 Nov 2022
AbstractforHigh LARGE1 Expression May Predict Benefit from Adjuvant Chemotherapy in Resected Non-Small-Cell Lung Cancer | Full Text | References | PDF (7.8 MB) | EPUB
  • 105 Views
  • 1 CrossRef citations
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Open Access
Article
STAT6 rs324015 Gene Polymorphism Increases Ulcerative Colitis Risk: A Case–Control Study
Lingying Dai, Dan Zhang, Yunzhi Qian, Yemin Wan, Shuchen Chang & Haihua Qian
Pages: 101-107
Published online: 17 Nov 2022
AbstractforSTAT6 rs324015 Gene Polymorphism Increases Ulcerative Colitis Risk: A Case–Control Study | Full Text | References | PDF (506.1 KB) | EPUB
  • 100 Views
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Open Access
Article
No Association Between FTO Gene Polymorphisms and Central Nervous System Tumor Susceptibility in Chinese Children
Yuxiang Liao, Li Yuan, Zhiping Zhang, Ao Lin, Jingying Zhou, Zhenjian Zhuo & Jie Zhao
Pages: 109-115
Published online: 17 Nov 2022
AbstractforNo Association Between FTO Gene Polymorphisms and Central Nervous System Tumor Susceptibility in Chinese Children | Full Text | References | PDF (298.6 KB) | EPUB
  • 109 Views
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Open Access
Article
Genetic Diversity of Drug-Related Genes in Native Americans of the Brazilian Amazon
Marianne Rodrigues Fernandes, Juliana Carla Gomes Rodrigues, Olalla Maroñas, Ana Latorre-Pellicer, Raquel Cruz, João Farias Guerreiro, Rommel Mario Rodriguez Burbano, Paulo Pimentel de Assumpção, Andrea Ribeiro-dos-Santos, Sidney Emanuel Batista dos Santos, Angel Carracedo & Ney Pereira Carneiro dos Santos
Pages: 117-133
Published online: 17 Nov 2022
AbstractforGenetic Diversity of Drug-Related Genes in Native Americans of the Brazilian Amazon | Full Text | References | PDF (4.5 MB) | EPUB
  • 307 Views
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Open Access
Article
CYP2C9 Variations and Their Pharmacogenetic Implications Among Diverse South Asian Populations
Sheikh Nizamuddin, Shivendra Dubey, Sakshi Singh, Saurav Sharma, Pratheusa Machha & Kumarasamy Thangaraj
Pages: 135-147
Published online: 17 Nov 2022
AbstractforCYP2C9 Variations and Their Pharmacogenetic Implications Among Diverse South Asian Populations | Full Text | References | PDF (2.5 MB) | EPUB
  • 215 Views
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Open Access

Case Report

Case Report
Genetic Polymorphism Effect on Warfarin–Rifampin Interaction: A Case Report and Review of Literature
Muhammad Salem, Islam Eljilany, Ahmed El-Bardissy & Hazem Elewa
Pages: 149-156
Published online: 17 Nov 2022
AbstractforGenetic Polymorphism Effect on Warfarin–Rifampin Interaction: A Case Report and Review of Literature | Full Text | References | PDF (593.1 KB) | EPUB
  • 282 Views
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Open Access

Original Research

Article
Relationship Between Interleukin-6 −174G/C Genetic Variant and Efficacy of Methotrexate Treatment in Psoriatic Arthritis Patients
Renata Sokolik, Milena Iwaszko, Jerzy Świerkot, Barbara Wysoczańska, Lucyna Korman, Piotr Wiland & Katarzyna Bogunia-Kubik
Pages: 157-166
Published online: 17 Nov 2022
AbstractforRelationship Between Interleukin-6 −174G/C Genetic Variant and Efficacy of Methotrexate Treatment in Psoriatic Arthritis Patients | Full Text | References | PDF (343.4 KB) | EPUB
  • 107 Views
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Open Access
Article
Assessment of the Role of Selected SMAD3 and SMAD4 Genes Polymorphisms in the Development of Colorectal Cancer: Preliminary Research
Agnieszka Wosiak, Damian Wodziński, Katarzyna Michalska, Jacek Pietrzak, Radzisław Kordek & Ewa Balcerczak
Pages: 167-178
Published online: 17 Nov 2022
AbstractforAssessment of the Role of Selected SMAD3 and SMAD4 Genes Polymorphisms in the Development of Colorectal Cancer: Preliminary Research | Full Text | References | PDF (331.7 KB) | EPUB
  • 123 Views
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Open Access
Article
The Association Between Azathioprine Genetic Polymorphisms, Clinical Efficacy and Adverse Drug Reactions Among Egyptian Patients with Autoimmune Diseases
Nermeen Abuelsoud, Hala Fayed & Engy Elkateeb
Pages: 179-187
Published online: 17 Nov 2022
AbstractforThe Association Between Azathioprine Genetic Polymorphisms, Clinical Efficacy and Adverse Drug Reactions Among Egyptian Patients with Autoimmune Diseases | Full Text | References | PDF (327.3 KB) | EPUB
  • 151 Views
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Open Access
Article
Association of CYP3A5 Gene Polymorphisms and Amlodipine-Induced Peripheral Edema in Chinese Han Patients with Essential Hypertension
Hao Liang, Xinru Zhang, Zhuo Ma, Yan Sun, Chang Shu, Yihua Zhu, Yanwei Zhang, Songnian Hu, Xiujuan Fu & Lihong Liu
Pages: 189-197
Published online: 17 Nov 2022
AbstractforAssociation of CYP3A5 Gene Polymorphisms and Amlodipine-Induced Peripheral Edema in Chinese Han Patients with Essential Hypertension | Full Text | References | PDF (327.8 KB) | EPUB
  • 185 Views
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Open Access
Article
TPMT Genetic Variability and Its Association with Hematotoxicity in Indonesian Children with Acute Lymphoblastic Leukemia in Maintenance Therapy
Dewi Selvina Rosdiana, Rianto Setiabudy, Rizka Andalusia, Djajadiman Gatot, Melva Louisa, Saptawati Bardosono & Instiaty Instiaty
Pages: 199-210
Published online: 17 Nov 2022
AbstractforTPMT Genetic Variability and Its Association with Hematotoxicity in Indonesian Children with Acute Lymphoblastic Leukemia in Maintenance Therapy | Full Text | References | PDF (2.8 MB) | EPUB
  • 163 Views
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Open Access
Article
Identification of Crucial Genes and Pathways Associated with Atherosclerotic Plaque in Diabetic Patients
Yuan-Yuan Li, Sheng Zhang, Hua Wang, Shun-Xiao Zhang, Ting Xu, Shu-Wen Chen, Yan Zhang & Yue Chen
Pages: 211-220
Published online: 17 Nov 2022
AbstractforIdentification of Crucial Genes and Pathways Associated with Atherosclerotic Plaque in Diabetic Patients | Full Text | References | PDF (5.8 MB) | EPUB
  • 120 Views
  • 1 CrossRef citations
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Open Access
Article
Correlations Between TIMD-4 Gene Variants and the Risk and Clinical Features of Rheumatoid Arthritis in a Chinese Population
Zhicheng Yang, Shuaikun Liu, Li Zhou, Hui Zhang & Nanwei Xu
Pages: 221-228
Published online: 17 Nov 2022
AbstractforCorrelations Between TIMD-4 Gene Variants and the Risk and Clinical Features of Rheumatoid Arthritis in a Chinese Population | Full Text | References | PDF (877.5 KB) | EPUB
  • 109 Views
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Open Access
Article
No Association Between Pharmacogenomics Variants and Hospital and Emergency Department Utilization: A Mayo Clinic Biobank Retrospective Study
Paul Y Takahashi, Euijung Ryu, Suzette J Bielinski, Matthew Hathcock, Gregory D Jenkins, James R Cerhan & Janet E Olson
Pages: 229-237
Published online: 17 Nov 2022
AbstractforNo Association Between Pharmacogenomics Variants and Hospital and Emergency Department Utilization: A Mayo Clinic Biobank Retrospective Study | Full Text | References | PDF (315 KB) | EPUB
  • 139 Views
  • 6 CrossRef citations
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Open Access
Article
Relevance of PD-L1 Non-Coding Polymorphisms on the Prognosis of a Genetically Admixed NSCLC Cohort
Juliana Machado-Rugolo, Tabatha Gutierrez Prieto, Alexandre Todorovic Fabro, Edwin Roger Parra Cuentas, Vanessa Karen Sá, Camila Machado Baldavira, Claudia Aparecida Rainho, Erick C Castelli, Cecilia Farhat, Teresa Yae Takagaki, Maria Aparecida Nagai & Vera Luiza Capelozzi
Pages: 239-252
Published online: 17 Nov 2022
AbstractforRelevance of PD-L1 Non-Coding Polymorphisms on the Prognosis of a Genetically Admixed NSCLC Cohort | Full Text | References | PDF (1.5 MB) | EPUB
  • 107 Views
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Open Access
Article
Optimization of Busulfan Dosing Regimen in Pediatric Patients Using a Population Pharmacokinetic Model Incorporating GST Mutations
Jinjie Yuan, Ning Sun, Xinying Feng, Huan He, Dong Mei, Guanghua Zhu & Libo Zhao
Pages: 253-268
Published online: 17 Nov 2022
AbstractforOptimization of Busulfan Dosing Regimen in Pediatric Patients Using a Population Pharmacokinetic Model Incorporating GST Mutations | Full Text | References | PDF (4.8 MB) | EPUB
  • 119 Views
  • 4 CrossRef citations
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Open Access
Article
TSC2 Mutations Were Associated with the Early Recurrence of Patients with HCC Underwent Hepatectomy
Kangjian Song, Fu He, Yang Xin, Ge Guan, Junyu Huo, Qingwei Zhu, Ning Fan, Yuan Guo, Yunjin Zang & Liqun Wu
Pages: 269-278
Published online: 17 Nov 2022
AbstractforTSC2 Mutations Were Associated with the Early Recurrence of Patients with HCC Underwent Hepatectomy | Full Text | References | PDF (1.2 MB) | EPUB
  • 116 Views
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Open Access

Case Report

Case Report
Enriching Medication Review with a Pharmacogenetic Profile – A Case of Tamoxifen Adverse Drug Reactions
Chiara Jeiziner, Céline K Stäuble, Markus L Lampert, Kurt E Hersberger & Henriette E Meyer zu Schwabedissen
Pages: 279-286
Published online: 17 Nov 2022
AbstractforEnriching Medication Review with a Pharmacogenetic Profile – A Case of Tamoxifen Adverse Drug Reactions | Full Text | References | PDF (291.1 KB) | EPUB
  • 141 Views
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Open Access

Original Research

Article
Whole-Exome Sequencing in Patients Affected by Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis Reveals New Variants Potentially Contributing to the Phenotype
Dora Janeth Fonseca, Adrien Morel, Kevin Llinás-Caballero, David Bolívar-Salazar & Paul Laissue
Pages: 287-299
Published online: 17 Nov 2022
AbstractforWhole-Exome Sequencing in Patients Affected by Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis Reveals New Variants Potentially Contributing to the Phenotype | Full Text | References | PDF (1.7 MB) | EPUB
  • 143 Views
  • 1 CrossRef citations
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Open Access

Review

Review Article
Tackling Drug Resistance in EGFR Exon 20 Insertion Mutant Lung Cancer
Laura Pacini, Andrew D Jenks, Simon Vyse, Christopher P Wilding, Amani Arthur & Paul H Huang
Pages: 301-317
Published online: 17 Nov 2022
AbstractforTackling Drug Resistance in EGFR Exon 20 Insertion Mutant Lung Cancer | Full Text | References | PDF (4 MB) | EPUB
  • 322 Views
  • 7 CrossRef citations
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Open Access

Original Research

Article
Evaluating the Impact of CYP3A5 Genotype on Post-Transplant Healthcare Resource Utilization in Pediatric Renal and Heart Transplant Recipients Receiving Tacrolimus
Amy L Pasternak, Vincent D Marshall, Christina L Gersch, James M Rae, Michael Englesbe & Jeong M Park
Pages: 319-326
Published online: 17 Nov 2022
AbstractforEvaluating the Impact of CYP3A5 Genotype on Post-Transplant Healthcare Resource Utilization in Pediatric Renal and Heart Transplant Recipients Receiving Tacrolimus | Full Text | References | PDF (1.7 MB) | EPUB
  • 110 Views
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Open Access

Review

Review Article
Challenges Involved in Incorporating Personalised Treatment Plan as Routine Care of Patients with Diabetes
Ranjit Unnikrishnan, Venkatesan Radha & Viswanathan Mohan
Pages: 327-333
Published online: 16 Mar 2021
AbstractforChallenges Involved in Incorporating Personalised Treatment Plan as Routine Care of Patients with Diabetes | Full Text | References | PDF (269.8 KB) | EPUB
  • 178 Views
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Open Access

Original Research

Article
Association of CYP2B6 Genetic Variation with Efavirenz and Nevirapine Drug Resistance in HIV-1 Patients from Botswana
Monkgomotsi J Maseng, Leabaneng Tawe, Prisca K Thami, Kaelo K Seatla, Sikhulile Moyo, Axel Martinelli, Ishmael Kasvosve, Vladimir Novitsky, Max Essex, Gianluca Russo, Simani Gaseitsiwe & Giacomo M Paganotti
Pages: 335-347
Published online: 16 Mar 2021
AbstractforAssociation of CYP2B6 Genetic Variation with Efavirenz and Nevirapine Drug Resistance in HIV-1 Patients from Botswana | Full Text | References | PDF (665.1 KB) | EPUB
  • 168 Views
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Open Access
Article
Skeletal Abnormalities and VDR1 Gene Polymorphisms in Mucopolysaccharidosis Patients
Camelia Alkhzouz, Georgiana Cabau, Cecilia Lazea, Carmen Asavoaie, Simona Bucerzan, Andreea Manuela Mirea, Marius Farcas, Maria Miclaus Jnr, Radu Popp & Diana Miclea
Pages: 349-358
Published online: 17 Mar 2021
AbstractforSkeletal Abnormalities and VDR1 Gene Polymorphisms in Mucopolysaccharidosis Patients | Full Text | References | PDF (2 MB) | EPUB
  • 167 Views
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Open Access
Article
The Association of Single-Nucleotide Polymorphism rs13181 in ERCC2 with Risk and Prognosis of Nasopharyngeal Carcinoma in an Endemic Chinese Population
Zhengbo Wei, Mengwei Yao, Sisi Ning, Yuan Wu, Xunzhao Zhou, Changtao Zhong, Kui Yan & Ying Xie
Pages: 359-367
Published online: 17 Nov 2022
AbstractforThe Association of Single-Nucleotide Polymorphism rs13181 in ERCC2 with Risk and Prognosis of Nasopharyngeal Carcinoma in an Endemic Chinese Population | Full Text | References | PDF (887.6 KB) | EPUB
  • 120 Views
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Open Access
Article
Influence of UGT1A1 *6/*28 Polymorphisms on Irinotecan-Related Toxicity and Survival in Pediatric Patients with Relapsed/Refractory Solid Tumors Treated with the VIT Regimen
Xiaoqin Zhu, Jia Zhu, Feifei Sun, Zijun Zhen, Dalei Zhou, Suying Lu, Junting Huang, Yi Que, Lian Zhang, Ruiqing Cai, Juan Wang & Yizhuo Zhang
Pages: 369-377
Published online: 23 Mar 2021
AbstractforInfluence of UGT1A1 *6/*28 Polymorphisms on Irinotecan-Related Toxicity and Survival in Pediatric Patients with Relapsed/Refractory Solid Tumors Treated with the VIT Regimen | Full Text | References | PDF (1.1 MB) | EPUB
  • 129 Views
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Open Access

Letter

Letter
Pathway to Ascertain the Role of Pharmacogenomics in Healthcare Utilization Outcomes [Letter]
Youssef M Roman
Pages: 379-380
Published online: 26 Mar 2021
CitationforPathway to Ascertain the Role of Pharmacogenomics in Healthcare Utilization Outcomes [Letter] | Full Text | References | PDF (220.5 KB) | EPUB
  • 98 Views
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Open Access

Original Research

Article
Correlation Study on HLA-DR and CD117 (c-Kit) Expressions: Its Prognosis and Treatment Response in Acute Myeloid Leukemia Patients
Yomna M El-Meligui, Heba E Abd Elrhman, Ahmad Salahuddin, Manal Ali Hamouda & Amira B Kassem
Pages: 381-393
Published online: 17 Nov 2022
AbstractforCorrelation Study on HLA-DR and CD117 (c-Kit) Expressions: Its Prognosis and Treatment Response in Acute Myeloid Leukemia Patients | Full Text | References | PDF (595.9 KB) | EPUB
  • 265 Views
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Open Access

Corrigendum

Correction
Association of CYP2B6 Genetic Variation with Efavirenz and Nevirapine Drug Resistance in HIV-1 Patients from Botswana [Corrigendum]
Page: 395
Published online: 31 Mar 2021
CitationforAssociation of CYP2B6 Genetic Variation with Efavirenz and Nevirapine Drug Resistance in HIV-1 Patients from Botswana [Corrigendum] | Full Text | PDF (163 KB) | EPUB
  • 78 Views
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Open Access

Original Research

Article
CHN1 is a Novel Prognostic Marker for Diffuse Large B-Cell Lymphoma
Jie Sun, Xiaoquan Zhu, Yanyang Zhao, Qi Zhou, Ruomei Qi & Hui Liu
Pages: 397-408
Published online: 01 Apr 2021
AbstractforCHN1 is a Novel Prognostic Marker for Diffuse Large B-Cell Lymphoma | Full Text | References | PDF (7.2 MB) | EPUB
  • 111 Views
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Open Access
Article
Non-Classical 21-Hydroxylase Deficiency: Analysis of a Mutant Gene in a Uyghur Family and Literature Review
Jimilanmu Maimaitiming, Guli Amuti, AiHeMaiTiJiang TuHuTi, Yuan Chen, Xiang-Xin Song, Jing Wang, Adila Alimu, Kaidi Zhang, Munila Abudounaiyimu, Jun Jiang, Xin-Ling Wang & Yan-Ying Guo
Pages: 409-416
Published online: 07 Apr 2021
AbstractforNon-Classical 21-Hydroxylase Deficiency: Analysis of a Mutant Gene in a Uyghur Family and Literature Review | Full Text | References | PDF (367.5 KB) | EPUB
  • 94 Views
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Open Access
Article
CYP2C9*3/*3 Gene Expression Affects the Total and Free Concentrations of Valproic Acid in Pediatric Patients with Epilepsy
Xikun Wu, Weichong Dong, Haoran Li, Xiuling Yang, Yiran Jin, Zhiqing Zhang & Ye Jiang
Pages: 417-430
Published online: 09 Apr 2021
AbstractforCYP2C9*3/*3 Gene Expression Affects the Total and Free Concentrations of Valproic Acid in Pediatric Patients with Epilepsy | Full Text | References | PDF (1.7 MB) | EPUB
  • 122 Views
  • 1 CrossRef citations
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Open Access
Article
Assessment of Weighted Gene Co-Expression Network Analysis to Explore Key Pathways and Novel Biomarkers in Muscular Dystrophy
Xiaoxue Xu, Yuehan Hao, Jiao Wu, Jing Zhao & Shuang Xiong
Pages: 431-444
Published online: 13 Apr 2021
AbstractforAssessment of Weighted Gene Co-Expression Network Analysis to Explore Key Pathways and Novel Biomarkers in Muscular Dystrophy | Full Text | References | PDF (9.3 MB) | EPUB
  • 151 Views
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Open Access
Article
CSF1R is a Prognostic Biomarker and Correlated with Immune Cell Infiltration in the Gastric Cancer Microenvironment
Di Chen, Lina Xiong, Li Zhang, Honglu Yu, Yushuang Xu, Mengmeng Wang, Xin Jiang & Zhifan Xiong
Pages: 445-457
Published online: 17 Nov 2022
AbstractforCSF1R is a Prognostic Biomarker and Correlated with Immune Cell Infiltration in the Gastric Cancer Microenvironment | Full Text | References | PDF (14 MB) | EPUB
  • 125 Views
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Open Access
Article
DNA Methylation of Fluoxetine Response in Child and Adolescence: Preliminary Results
Albert Martinez-Pinteño, Natalia Rodriguez, Ana Blázquez, Maria Teresa Plana, Eva Varela, Patricia Gassó, Amalia Lafuente, Luisa Lazaro & Sergi Mas
Pages: 459-467
Published online: 19 Apr 2021
AbstractforDNA Methylation of Fluoxetine Response in Child and Adolescence: Preliminary Results | Full Text | References | PDF (1.3 MB) | EPUB
  • 140 Views
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Open Access
Article
The EGFR Polymorphism Increased the Risk of Hepatocellular Carcinoma Through the miR-3196-Dependent Approach in Chinese Han Population
Li Zhang, Xiaoping Li, Jiang Lu, Yi Qian, Tao Qian, Xing Wu & Qinghua Xu
Pages: 469-476
Published online: 23 Apr 2021
AbstractforThe EGFR Polymorphism Increased the Risk of Hepatocellular Carcinoma Through the miR-3196-Dependent Approach in Chinese Han Population | Full Text | References | PDF (339.9 KB) | EPUB
  • 106 Views
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Open Access

Clinical Trial Report

Case Report
The Impact of ABCB1 and CES1 Polymorphisms on Dabigatran Pharmacokinetics in Healthy Chinese Subjects
Yue Liu, Chenguang Yang, Wenyuan Qi, Zuowei Pei, Wei Xue, Huolan Zhu, Min Dong, Ying Guo, Duanduan Cong & Fang Wang
Pages: 477-485
Published online: 23 Apr 2021
AbstractforThe Impact of ABCB1 and CES1 Polymorphisms on Dabigatran Pharmacokinetics in Healthy Chinese Subjects | Full Text | References | PDF (780 KB) | EPUB
  • 206 Views
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Open Access

Perspectives

Discussion
Towards a Clinical Efficacy Evaluation System Adapted for Personalized Medicine
Bing Yuan
Pages: 487-496
Published online: 28 Apr 2021
AbstractforTowards a Clinical Efficacy Evaluation System Adapted for Personalized Medicine | Full Text | References | PDF (278 KB) | EPUB
  • 157 Views
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Open Access

Original Research

Article
Reversal of Chemotherapy Resistance to Cisplatin in NSCLC by miRNA-195-5p via Targeting the FGF2 Gene
Hao Wang, Zhi-lin Sui, Xian-xian Wu, Peng Tang, Hong-dian Zhang & Zhen-tao Yu
Pages: 497-508
Published online: 28 Apr 2021
AbstractforReversal of Chemotherapy Resistance to Cisplatin in NSCLC by miRNA-195-5p via Targeting the FGF2 Gene | Full Text | References | PDF (711.8 KB) | EPUB
  • 127 Views
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Open Access
Article
Evaluation of CYP2C19 Gene Polymorphisms in Patients with Acid Peptic Disorders Treated with Esomeprazole
Lorena Díaz-Ordóñez, Diana Ramírez-Montaño, Estephania Candelo, Carolina González-Restrepo, Sebastián Silva-Peña, Carlos Arturo Rojas, Mario Sepulveda Copete, Hector Raul Echavarria & Harry Pachajoa
Pages: 509-520
Published online: 17 Nov 2022
AbstractforEvaluation of CYP2C19 Gene Polymorphisms in Patients with Acid Peptic Disorders Treated with Esomeprazole | Full Text | References | PDF (517.6 KB) | EPUB
  • 214 Views
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Open Access
Article
Digital PCR Detection of mtDNA/gDNA Ratio in Embryo Culture Medium for Prediction of Embryo Development Potential
Qing Zhang, Hong Ji, Jian Shi, Longmei Wang, Lu Ding, Yufei Jiang, Xianjing Huang, Pingping Qiu Snr & Ping Li
Pages: 521-531
Published online: 30 Apr 2021
AbstractforDigital PCR Detection of mtDNA/gDNA Ratio in Embryo Culture Medium for Prediction of Embryo Development Potential | Full Text | References | PDF (449.6 KB) | EPUB
  • 125 Views
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Open Access
Article
BRCA2 3ʹ-UTR Polymorphism rs15869 Alters Susceptibility to Papillary Thyroid Carcinoma via Binding hsa-mir-1178-3p
Nan Guo, Peng Qu, Hao Li, Liuli Liu, Hao Jin, Renqi Liu, Zhen Zhang, Xuan Zhang, Yingchun Li, Xiaobo Lu & Yuejiao Zhao
Pages: 533-544
Published online: 06 May 2021
AbstractforBRCA2 3ʹ-UTR Polymorphism rs15869 Alters Susceptibility to Papillary Thyroid Carcinoma via Binding hsa-mir-1178-3p | Full Text | References | PDF (559.1 KB) | EPUB
  • 102 Views
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Open Access

Response to Letter

Reply
Pathway to Ascertain the Role of Pharmacogenomics in Healthcare Utilization Outcomes [Response to Letter]
Paul Y Takahashi, Euijung Ryu, James R Cerhan, Suzette J Bielinski & Janet E Olson
Pages: 545-546
Published online: 06 May 2021
CitationforPathway to Ascertain the Role of Pharmacogenomics in Healthcare Utilization Outcomes [Response to Letter] | Full Text | References | PDF (207.3 KB) | EPUB
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Original Research

Article
Genetic Association Study Revealed Three Loci Were Associated Risk of Myopia Among Minors
Zixiu Zhou, Sizhen Li, Qingsong Yang, Xiaodong Yang, Kuanxiao Hao, Yating Liu & Shanshan Xu
Pages: 547-551
Published online: 17 Nov 2022
AbstractforGenetic Association Study Revealed Three Loci Were Associated Risk of Myopia Among Minors | Full Text | References | PDF (235.5 KB) | EPUB
  • 103 Views
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Open Access
Article
Circulating Level of Monocyte Chemoattractant Protein-1 and Risk of Coronary Artery Disease: A Case–Control and Mendelian Randomization Study
Jing Li, Yanqun Zhang, Xue Guo, Yuanyuan Wu, Ruo Huang & Xia Han
Pages: 553-559
Published online: 17 Nov 2022
AbstractforCirculating Level of Monocyte Chemoattractant Protein-1 and Risk of Coronary Artery Disease: A Case–Control and Mendelian Randomization Study | Full Text | References | PDF (300.5 KB) | EPUB
  • 109 Views
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Open Access
Article
Genetic Variants, Circulating Level of MCP1 with Risk of Chronic Obstructive Pulmonary Disease: A Case-Control Study
Chunyi Lin, Zhimin Wang, Lu Shen, Gao Yi, Meichan Li & Defu Li
Pages: 561-567
Published online: 17 Nov 2022
AbstractforGenetic Variants, Circulating Level of MCP1 with Risk of Chronic Obstructive Pulmonary Disease: A Case-Control Study | Full Text | References | PDF (323.7 KB) | EPUB
  • 109 Views
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Open Access

Review

Review Article
Pharmacogenomics in the United States Community Pharmacy Setting: The Clopidogrel-CYP2C19 Example
David F Kisor, Natasha J Petry & David R Bright
Pages: 569-577
Published online: 17 Nov 2022
AbstractforPharmacogenomics in the United States Community Pharmacy Setting: The Clopidogrel-CYP2C19 Example | Full Text | References | PDF (346.1 KB) | EPUB
  • 188 Views
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Open Access

Original Research

Article
Trigger-Specific Remodeling of KCa2 Potassium Channels in Models of Atrial Fibrillation
Ann-Kathrin Rahm, Dominik Gramlich, Teresa Wieder, Mara Elena Müller, Axel Schoeffel, Fadwa A El Tahry, Patrick Most, Tanja Heimberger, Steffi Sandke, Tanja Weis, Nina D Ullrich, Thomas Korff, Patrick Lugenbiel, Hugo A Katus & Dierk Thomas
Pages: 579-590
Published online: 17 Nov 2022
AbstractforTrigger-Specific Remodeling of KCa2 Potassium Channels in Models of Atrial Fibrillation | Full Text | References | PDF (611.4 KB) | EPUB
  • 154 Views
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Open Access
Article
CD24 Contributes to Treatment Effect in ABC-DLBCL Patients with R-CHOP Resistance
Li-Yan Qiao, Han-Bing Li, Yue Zhang, Di Shen, Peng Liu & Yi-Qun Che
Pages: 591-599
Published online: 17 Nov 2022
AbstractforCD24 Contributes to Treatment Effect in ABC-DLBCL Patients with R-CHOP Resistance | Full Text | References | PDF (2.3 MB) | EPUB
  • 103 Views
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Open Access
Article
Association of HMGA2 Polymorphisms with Glioma Susceptibility in Chinese Children
Jingying Zhou, Pan Wang, Ran Zhang, Xiaokai Huang, Hanqi Dai, Li Yuan & Jichen Ruan
Pages: 601-607
Published online: 17 Nov 2022
AbstractforAssociation of HMGA2 Polymorphisms with Glioma Susceptibility in Chinese Children | Full Text | References | PDF (361.9 KB) | EPUB
  • 108 Views
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Open Access
Article
Ferroptosis-Related Gene Signature: A New Method for Personalized Risk Assessment in Patients with Diffuse Large B-Cell Lymphoma
Huan Chen, Yizi He, Tao Pan, Ruolan Zeng, Yajun Li, Siwei Chen, Yufeng Li, Ling Xiao & Hui Zhou
Pages: 609-619
Published online: 17 Nov 2022
AbstractforFerroptosis-Related Gene Signature: A New Method for Personalized Risk Assessment in Patients with Diffuse Large B-Cell Lymphoma | Full Text | References | PDF (8.1 MB) | EPUB
  • 134 Views
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Open Access
Article
Angiotensin System Polymorphisms’ in SARS-CoV-2 Positive Patients: Assessment Between Symptomatic and Asymptomatic Patients: A Pilot Study
Concetta Cafiero, Felice Rosapepe, Raffaele Palmirotta, Agnese Re, Maria Pia Ottaiano, Giulio Benincasa, Romina Perone, Elisa Varriale, Gerardo D’Amato, Andrea Cacciamani, Alessandra Micera & Salvatore Pisconti
Pages: 621-629
Published online: 17 Nov 2022
AbstractforAngiotensin System Polymorphisms’ in SARS-CoV-2 Positive Patients: Assessment Between Symptomatic and Asymptomatic Patients: A Pilot Study | Full Text | References | PDF (397.4 KB) | EPUB
  • 212 Views
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Open Access

Review

Review Article
Personalizing the Care and Treatment of Alzheimer’s Disease: An Overview
Dubravka Svob Strac, Marcela Konjevod, Marina Sagud, Matea Nikolac Perkovic, Gordana Nedic Erjavec, Barbara Vuic, Goran Simic, Vana Vukic, Ninoslav Mimica & Nela Pivac
Pages: 631-653
Published online: 17 Nov 2022
AbstractforPersonalizing the Care and Treatment of Alzheimer’s Disease: An Overview | Full Text | References | PDF (2.5 MB) | EPUB
  • 533 Views
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Open Access

Original Research

Article
Physicians’ Knowledge and Attitudes Regarding Point-of-Care Pharmacogenetic Testing: A Hospital-Based Cross-Sectional Study
Suhaib Muflih, Osama Y Alshogran, Sayer Al-Azzam, Ghaith Al-Taani & Yousef S Khader
Pages: 655-665
Published online: 17 Nov 2022
AbstractforPhysicians’ Knowledge and Attitudes Regarding Point-of-Care Pharmacogenetic Testing: A Hospital-Based Cross-Sectional Study | Full Text | References | PDF (331.7 KB) | EPUB
  • 238 Views
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Open Access
Article
Identification and Validation of Immune-Related lncRNA Signature as a Prognostic Model for Skin Cutaneous Melanoma
Shuai Ping, Siyuan Wang, Jinbing He & Jianghai Chen
Pages: 667-681
Published online: 17 Nov 2022
AbstractforIdentification and Validation of Immune-Related lncRNA Signature as a Prognostic Model for Skin Cutaneous Melanoma | Full Text | References | PDF (931.4 KB) | EPUB
  • 123 Views
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Open Access
Article
Identification of Independent and Communal Differentially Expressed Genes as Well as Potential Therapeutic Targets in Ischemic Heart Failure and Non-Ischemic Heart Failure
Zuoxiang Wang, Mingyang Zhang, Yinan Xu, Yiyu Gu, Yumeng Song & Tingbo Jiang
Pages: 683-693
Published online: 17 Nov 2022
AbstractforIdentification of Independent and Communal Differentially Expressed Genes as Well as Potential Therapeutic Targets in Ischemic Heart Failure and Non-Ischemic Heart Failure | Full Text | References | PDF (7.6 MB) | EPUB
  • 97 Views
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Open Access
Article
Mitochondrial Dynamics Related Genes -MFN1, MFN2 and DRP1 Polymorphisms are Associated with Risk of Lung Cancer
Xiaohua Liang & Shengqiang Dang
Pages: 695-703
Published online: 17 Nov 2022
AbstractforMitochondrial Dynamics Related Genes -MFN1, MFN2 and DRP1 Polymorphisms are Associated with Risk of Lung Cancer | Full Text | References | PDF (328.7 KB) | EPUB
  • 139 Views
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Open Access
Article
A Functional Variant rs2072915 is Associated with the Susceptibility and Mortality of Cervical Squamous Cell Carcinoma
Ren-Liang Li, Jiao-Hong Wu, Min Guo, Li-Xiao Sha, Shu-Qi Xia & Lian Xu
Pages: 705-712
Published online: 17 Nov 2022
AbstractforA Functional Variant rs2072915 is Associated with the Susceptibility and Mortality of Cervical Squamous Cell Carcinoma | Full Text | References | PDF (1.9 MB) | EPUB
  • 87 Views
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Open Access
Article
Influence of SLCO1B1 521T>C, UGT2B7 802C>T and IMPDH1 −106G>A Genetic Polymorphisms on Mycophenolic Acid Levels and Adverse Reactions in Chinese Autoimmune Disease Patients
Qing Shu, Qingqing Fan, Bingzhu Hua, Hang Liu, Shiying Wang, Yunxing Liu, Yao Yao, Han Xie & Weihong Ge
Pages: 713-722
Published online: 17 Nov 2022
AbstractforInfluence of SLCO1B1 521T>C, UGT2B7 802C>T and IMPDH1 −106G>A Genetic Polymorphisms on Mycophenolic Acid Levels and Adverse Reactions in Chinese Autoimmune Disease Patients | Full Text | References | PDF (679.5 KB) | EPUB
  • 118 Views
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Open Access
Article
The Phenomenon of Gene Rearrangement is Frequently Associated with TP53 Mutations and Poor Disease-Free Survival in Hepatocellular Carcinoma
Fu He, Kangjian Song, Ge Guan, Junyu Huo, Yang Xin, Tianxiang Li, Chao Liu, Qingwei Zhu, Ning Fan, Yuan Guo & Liqun Wu
Pages: 723-736
Published online: 17 Nov 2022
AbstractforThe Phenomenon of Gene Rearrangement is Frequently Associated with TP53 Mutations and Poor Disease-Free Survival in Hepatocellular Carcinoma | Full Text | References | PDF (8.6 MB) | EPUB
  • 115 Views
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Open Access
Article
Acetylator Status Among Newly Diagnosed and Recurrent Tuberculosis Patients from Kupang, Eastern Part of Indonesia
Edhyana Sahiratmadja, Ika Agus Rini, Simeon Penggoam, Afandi Charles, Ani Melani Maskoen & Ida Parwati
Pages: 737-744
Published online: 17 Nov 2022
AbstractforAcetylator Status Among Newly Diagnosed and Recurrent Tuberculosis Patients from Kupang, Eastern Part of Indonesia | Full Text | References | PDF (246.2 KB) | EPUB
  • 205 Views
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Open Access
Article
A Two-Stage Study Identifies Two Novel Polymorphisms in PRKAG2 Affecting Metformin Response in Chinese Type 2 Diabetes Patients
Di Xiao, Jun-Yan Liu, Si-Min Zhang, Rang-Ru Liu, Ji-Ye Yin, Xue-Yao Han, Xi Li, Wei Zhang, Xiao-Ping Chen, Hong-Hao Zhou, Li-Nong Ji & Zhao-Qian Liu
Pages: 745-755
Published online: 17 Nov 2022
AbstractforA Two-Stage Study Identifies Two Novel Polymorphisms in PRKAG2 Affecting Metformin Response in Chinese Type 2 Diabetes Patients | Full Text | References | PDF (3.5 MB) | EPUB
  • 155 Views
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Open Access
Article
Integrative DNA Methylation and Gene Expression Analysis of Cognitive Behavioral Therapy Response in Children and Adolescents with Obsessive-Compulsive Disorder; a Pilot Study
Natalia Rodriguez, Albert Martinez-Pinteño, Ana Blázquez, Ana Encarnación Ortiz, Elena Moreno, Patricia Gassó, Amalia Lafuente, Luisa Lazaro & Sergi Mas
Pages: 757-766
Published online: 17 Nov 2022
AbstractforIntegrative DNA Methylation and Gene Expression Analysis of Cognitive Behavioral Therapy Response in Children and Adolescents with Obsessive-Compulsive Disorder; a Pilot Study | Full Text | References | PDF (1.6 MB) | EPUB
  • 234 Views
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Open Access
Article
Identification of Potential Key Genes and Regulatory Markers in Essential Thrombocythemia Through Integrated Bioinformatics Analysis and Clinical Validation
Jie Wang, Yun Wu, Md Nazim Uddin, Rong Chen & Jian-Ping Hao
Pages: 767-784
Published online: 17 Nov 2022
AbstractforIdentification of Potential Key Genes and Regulatory Markers in Essential Thrombocythemia Through Integrated Bioinformatics Analysis and Clinical Validation | Full Text | References | PDF (8.8 MB) | EPUB
  • 176 Views
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Open Access
Article
Delivery of Pharmacogenetic Testing with or without Medication Therapy Management in a Community Pharmacy Setting
Susanne B Haga, Rachel Mills, Jivan Moaddeb, Yiling Liu & Deepak Voora
Pages: 785-796
Published online: 17 Nov 2022
AbstractforDelivery of Pharmacogenetic Testing with or without Medication Therapy Management in a Community Pharmacy Setting | Full Text | References | PDF (352.9 KB) | EPUB
  • 148 Views
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Open Access
Article
Signature Panel of 11 Methylated mRNAs and 3 Methylated lncRNAs for Prediction of Recurrence-Free Survival in Prostate Cancer Patients
Jiarong Cai, Fei Yang, Xuelian Chen, He Huang & Bin Miao
Pages: 797-811
Published online: 17 Nov 2022
AbstractforSignature Panel of 11 Methylated mRNAs and 3 Methylated lncRNAs for Prediction of Recurrence-Free Survival in Prostate Cancer Patients | Full Text | References | PDF (8.1 MB) | EPUB
  • 100 Views
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Open Access
Article
Single-Nucleotide Polymorphisms Related to Leprosy Risk and Clinical Phenotypes Among Chinese Population
Si-Yu Long, Le Wang, Hai-Qin Jiang, Ying Shi, Wen-Yue Zhang, Jing-Shu Xiong, Pei-Wen Sun, Yan-Qing Chen, You-Ming Mei, Chun Pan, Gai Ge, Zhen-Zhen Wang, Zi-Wei Wu, Mei-Wen Yu & Hong-Sheng Wang
Pages: 813-821
Published online: 17 Nov 2022
AbstractforSingle-Nucleotide Polymorphisms Related to Leprosy Risk and Clinical Phenotypes Among Chinese Population | Full Text | References | PDF (357.5 KB) | EPUB
  • 137 Views
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Open Access
Article
Identification of Underlying Hub Genes Associated with Hypertrophic Cardiomyopathy by Integrated Bioinformatics Analysis
Zetao Ma, Xizhi Wang, Qingbo Lv, Yingchao Gong, Minghong Xia, Lenan Zhuang, Xue Lu, Ying Yang, Wenbin Zhang, Guosheng Fu, Yang Ye & Dongwu Lai
Pages: 823-837
Published online: 17 Nov 2022
AbstractforIdentification of Underlying Hub Genes Associated with Hypertrophic Cardiomyopathy by Integrated Bioinformatics Analysis | Full Text | References | PDF (11 MB) | EPUB
  • 181 Views
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Open Access
Article
Interactive Association Between Intronic Polymorphism (rs10506151) of the LRRK2 Gene and Type 2 Diabetes on Neurodegenerative Diseases
Mei-Hsuen Huang, Yu-Fan Liu, Oswald Ndi Nfor, Shu-Yi Hsu, Wei-Yong Lin, Yuan-Shiun Chang & Yung-Po Liaw
Pages: 839-847
Published online: 13 Jul 2021
AbstractforInteractive Association Between Intronic Polymorphism (rs10506151) of the LRRK2 Gene and Type 2 Diabetes on Neurodegenerative Diseases | Full Text | References | PDF (668.4 KB) | EPUB
  • 114 Views
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Open Access
Article
Bioinformatics Analysis of Neuroblastoma miRNA Based on GEO Data
Jiandong Shi, Piaoyan Zhang, Huarong Su, Lingyi Cai, Liang Zhao & Haixia Zhou
Pages: 849-858
Published online: 13 Jul 2021
AbstractforBioinformatics Analysis of Neuroblastoma miRNA Based on GEO Data | Full Text | References | PDF (7.9 MB) | EPUB
  • 162 Views
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Open Access
Article
IDUA Gene Variants and Response to Zoledronic Acid Treatment in Chinese Women with Postmenopausal Osteoporosis
Haiqing Lin, Jin Li, Zhonghua Xu, Ting Liu & Xindie Zhou
Pages: 859-866
Published online: 13 Jul 2021
AbstractforIDUA Gene Variants and Response to Zoledronic Acid Treatment in Chinese Women with Postmenopausal Osteoporosis | Full Text | References | PDF (328.8 KB) | EPUB
  • 110 Views
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Open Access
Article
Clinical Observation of Gene Polymorphism of Olanzapine or Aprepitant in Prevention of CINV
Yilan Jin, Gaowa Jin, Jun Zhao, Caihong Jiang, Lanzhen Zhao, Ying Jiang, Feng Chen, Hui Li, Wenjuan Wang, Yungaowa Wu, Guang Liu, Xiaorong Li, Min Gu, Xiaomei Li & Quanfu Li
Pages: 867-875
Published online: 15 Jul 2021
AbstractforClinical Observation of Gene Polymorphism of Olanzapine or Aprepitant in Prevention of CINV | Full Text | References | PDF (382.8 KB) | EPUB
  • 126 Views
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Open Access
Article
Independent Community Pharmacists’ Experience in Offering Pharmacogenetic Testing
Susanne B Haga, Rachel Mills, Jivan Moaddeb, Yiling Liu & Deepak Voora
Pages: 877-886
Published online: 15 Jul 2021
AbstractforIndependent Community Pharmacists’ Experience in Offering Pharmacogenetic Testing | Full Text | References | PDF (984.1 KB) | EPUB
  • 190 Views
  • 3 CrossRef citations
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Open Access
Article
Genome-Wide Identification of m6A-Associated Single-Nucleotide Polymorphisms in Colorectal Cancer
Hongying Zhao, Jinying Jiang, Mingshan Wang & Zixue Xuan
Pages: 887-892
Published online: 17 Jul 2021
AbstractforGenome-Wide Identification of m6A-Associated Single-Nucleotide Polymorphisms in Colorectal Cancer | Full Text | References | PDF (2.2 MB) | EPUB
  • 124 Views
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Open Access
Article
C5 Variant rs10985126 is Associated with Mortality in Patients with Symptomatic Coronary Artery Disease
Jessica Kristin Henes, Patrick Groga-Bada, Elke Schaeffeler, Stefan Winter, Luis Hack, Monika Zdanyte, Karin Mueller, Michal Droppa, Fabian Stimpfle, Meinrad Gawaz, Harald Langer, Matthias Schwab, Tobias Geisler & Dominik Rath
Pages: 893-903
Published online: 21 Jul 2021
AbstractforC5 Variant rs10985126 is Associated with Mortality in Patients with Symptomatic Coronary Artery Disease | Full Text | References | PDF (1.2 MB) | EPUB
  • 118 Views
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Open Access
Article
The Expression of miR-365 in Serum of Hypertension Patients with Left Ventricular Hypertrophy Was Up-Regulated, Which Was Positively Correlated with Left Ventricular Mass Index
Hai-bo Wu, Chen-si Yang, Yun-can Wang, Yue-tao Xie, Xue-chao Wang, Hui-liang Liu & Rong-pin Du
Pages: 905-913
Published online: 17 Nov 2022
AbstractforThe Expression of miR-365 in Serum of Hypertension Patients with Left Ventricular Hypertrophy Was Up-Regulated, Which Was Positively Correlated with Left Ventricular Mass Index | Full Text | References | PDF (966.7 KB) | EPUB
  • 95 Views
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Open Access
Article
Influence of SULT1A1*2 Polymorphism on Plasma Efavirenz Concentration in Thai HIV-1 Patients
Monpat Chamnanphon, Rattanaporn Sukprasong, Andrea Gaedigk, Weerawat Manosuthi, Pajaree Chariyavilaskul, Supeecha Wittayalertpanya, Napatrupron Koomdee, Thawinee Jantararoungtong, Apichaya Puangpetch & Chonlaphat Sukasem
Pages: 915-926
Published online: 24 Jul 2021
AbstractforInfluence of SULT1A1*2 Polymorphism on Plasma Efavirenz Concentration in Thai HIV-1 Patients | Full Text | References | PDF (1.5 MB) | EPUB
  • 110 Views
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Open Access
Article
Prognostic Role and Potential Mechanisms of the Ferroptosis-Related Metabolic Gene Signature in Hepatocellular Carcinoma
Tianxing Dai, Jing Li, Xu Lu, Linsen Ye, Haoyuan Yu, Lele Zhang, Mingbin Deng, Shuguang Zhu, Wei Liu, Guoying Wang & Yang Yang
Pages: 927-945
Published online: 03 Aug 2021
AbstractforPrognostic Role and Potential Mechanisms of the Ferroptosis-Related Metabolic Gene Signature in Hepatocellular Carcinoma | Full Text | References | PDF (19.9 MB) | EPUB
  • 117 Views
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Open Access

Case Report

Case Report
Ovarian Sertoli-Leydig Cell Tumor, Multinodular Goiter, Cystic Nephromas and DICER1 Mutations: Case Report and Literature Review
Yanglin Ni, Xuan Zhou, Ling Wu, Ping Wu, Ying Liu, Yinnan Li, Li Cai, Xueshu Fu & Chunhua Zhang
Pages: 947-953
Published online: 03 Aug 2021
AbstractforOvarian Sertoli-Leydig Cell Tumor, Multinodular Goiter, Cystic Nephromas and DICER1 Mutations: Case Report and Literature Review | Full Text | References | PDF (1.9 MB) | EPUB
  • 125 Views
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Open Access

Original Research

Article
Individualized Drugs’ Selection by Evaluation of Drug Properties, Pharmacogenomics and Clinical Parameters: Performance of a Bioinformatic Tool Compared to a Clinically Established Counselling Process
Marina Borro, Giovanna Gentile, Sally H Preissner, Leda Marina Pomes, Björn-Oliver Gohlke, Antonio Del Casale, Andreas Eckert, Paolo Marchetti, Saskia Preissner, Robert Preissner & Maurizio Simmaco
Pages: 955-962
Published online: 05 Aug 2021
AbstractforIndividualized Drugs’ Selection by Evaluation of Drug Properties, Pharmacogenomics and Clinical Parameters: Performance of a Bioinformatic Tool Compared to a Clinically Established Counselling Process | Full Text | References | PDF (991.2 KB) | EPUB
  • 179 Views
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Open Access

Case Report

Case Report
Case Report: Fatigue and Bleeding in a Polymedicated Patient Using Several Herbal Supplementations, Detected with g-Nomic® Software
Abel Saldarreaga Marin, Marc Cendros, Carlos J Ciudad & Ana Sabater
Pages: 963-970
Published online: 12 Aug 2021
AbstractforCase Report: Fatigue and Bleeding in a Polymedicated Patient Using Several Herbal Supplementations, Detected with g-Nomic® Software | Full Text | References | PDF (9.2 MB) | EPUB
  • 126 Views
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Open Access

Original Research

Article
Association Between Insomnia and Migraine Risk: A Case–Control and Bidirectional Mendelian Randomization Study
Shujuan Chu, Zhilin Wu, Zhouyang Wu, Jing Wu & Yue Qian
Pages: 971-976
Published online: 13 Aug 2021
AbstractforAssociation Between Insomnia and Migraine Risk: A Case–Control and Bidirectional Mendelian Randomization Study | Full Text | References | PDF (319.5 KB) | EPUB
  • 220 Views
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Article
Genetic Variation of Inflammatory Genes to Ischemic Stroke Risk in a Chinese Han Population
Zhongqiu Zhang, Yanping Mei, Mengqiu Xiong, Fang Lu, Xianghong Zhao, Junrong Zhu & Bangshun He
Pages: 977-986
Published online: 17 Nov 2022
AbstractforGenetic Variation of Inflammatory Genes to Ischemic Stroke Risk in a Chinese Han Population | Full Text | References | PDF (442.5 KB) | EPUB
  • 108 Views
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Open Access

Review

Review Article
The Value of Population Screening in Advancing Personalized Medicine in the Field of Lung Cancer
Alice Mogenet, Laurent Greillier & Pascale Tomasini
Pages: 987-996
Published online: 17 Nov 2022
AbstractforThe Value of Population Screening in Advancing Personalized Medicine in the Field of Lung Cancer | Full Text | References | PDF (708.2 KB) | EPUB
  • 105 Views
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Open Access

Original Research

Article
Long Non-Coding RNAs Gene Variants as Molecular Markers for Diabetic Retinopathy Risk and Response to Anti-VEGF Therapy
Hala M F Mohammad, Ahmed A Abdelghany, Essam Al Ageeli, Shahad W Kattan, Ranya Hassan, Eman A Toraih, Manal S Fawzy & Naglaa Mokhtar
Pages: 997-1014
Published online: 14 Aug 2021
AbstractforLong Non-Coding RNAs Gene Variants as Molecular Markers for Diabetic Retinopathy Risk and Response to Anti-VEGF Therapy | Full Text | References | PDF (3.1 MB) | EPUB
  • 187 Views
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Open Access
Article
Economic Impact of the Application of a Precision Medicine Model (5SPM) on Psychotic Patients
Lorena Carrascal-Laso, Manuel Ángel Franco-Martín, Elena Marcos-Vadillo, Ignacio Ramos-Gallego, Belén García-Berrocal, Eduardo Mayor-Toranzo, Santiago Sánchez-Iglesias, Carolina Lorenzo, Alfonso Sevillano-Jiménez, Almudena Sánchez-Martín, María Jesús García-Salgado & María Isidoro-García
Pages: 1015-1025
Published online: 17 Nov 2022
AbstractforEconomic Impact of the Application of a Precision Medicine Model (5SPM) on Psychotic Patients | Full Text | References | PDF (3.1 MB) | EPUB
  • 175 Views
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Article
Population Genetic Difference of Pharmacogenomic VIP Variants in the Tibetan Population
Chunjuan He, Linna Peng, Shishi Xing, Dandan Li, Li Wang & Tianbo Jin
Pages: 1027-1040
Published online: 16 Aug 2021
AbstractforPopulation Genetic Difference of Pharmacogenomic VIP Variants in the Tibetan Population | Full Text | References | PDF (522.9 KB) | EPUB
  • 116 Views
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Open Access

Case Report

Case Report
A Chinese Boy with Mowat–Wilson Syndrome Caused by a 10 bp Deletion in the ZEB2 Gene
Lin Wei, Xiao Han, Xue Li, Bingjuan Han & Wenying Nie
Pages: 1041-1045
Published online: 17 Nov 2022
AbstractforA Chinese Boy with Mowat–Wilson Syndrome Caused by a 10 bp Deletion in the ZEB2 Gene | Full Text | References | PDF (451.6 KB) | EPUB
  • 106 Views
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Original Research

Article
Genetic Polymorphisms of FCRL3, NLRP3 and IL2 are Associated with the Risk of Head and Neck Cancer in a Chinese Population
Yuhao Zhang & Dawei Sun
Pages: 1047-1053
Published online: 26 Aug 2021
AbstractforGenetic Polymorphisms of FCRL3, NLRP3 and IL2 are Associated with the Risk of Head and Neck Cancer in a Chinese Population | Full Text | References | PDF (360 KB) | EPUB
  • 132 Views
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Open Access
Article
Haematological Indicators of Response to Erythropoietin Therapy in Chronic Renal Failure Patients on Haemodialysis: Impact of Angiotensin-Converting Enzyme rs4343 Gene Polymorphism
Abdulrahman Hamdan Almaeen & Gomaa Mostafa-Hedeab
Pages: 1055-1068
Published online: 17 Nov 2022
AbstractforHaematological Indicators of Response to Erythropoietin Therapy in Chronic Renal Failure Patients on Haemodialysis: Impact of Angiotensin-Converting Enzyme rs4343 Gene Polymorphism | Full Text | References | PDF (3 MB) | EPUB
  • 238 Views
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Open Access
Article
Genetic and Non-Genetic Factors Impact on INR Normalization in Preprocedural Warfarin Management
Islam Eljilany, Mohamed Elarref, Nabil Shallik, Abdel-Naser Elzouki, Loulia Bader, Ahmed El-Bardissy, Osama Abdelsamad, Daoud Al-Badriyeh, Larisa H Cavallari & Hazem Elewa
Pages: 1069-1080
Published online: 17 Nov 2022
AbstractforGenetic and Non-Genetic Factors Impact on INR Normalization in Preprocedural Warfarin Management | Full Text | References | PDF (4.1 MB) | EPUB
  • 190 Views
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Article
Association of Genetic Variants in miR-217 Gene with Risk of Coronary Artery Disease: A Case–Control Study
Xia Han, Xiaotang Liang, Menghai Wu, Lijun Zhang & Honglei Jiang
Pages: 1081-1086
Published online: 17 Nov 2022
AbstractforAssociation of Genetic Variants in miR-217 Gene with Risk of Coronary Artery Disease: A Case–Control Study | Full Text | References | PDF (1.4 MB) | EPUB
  • 98 Views
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Article
Interactive Association Between CYP2C9 rs2860905 Polymorphism and Atrial Fibrillation on Ischemic Stroke in Taiwan Biobank Participants
Jui-Wen Peng, Oswald Ndi Nfor, Chien-Chang Ho, Shu-Yi Hsu, Chia-Chi Lung, Disline Manli Tantoh, Ming-Chih Chou & Yung-Po Liaw
Pages: 1087-1092
Published online: 31 Aug 2021
AbstractforInteractive Association Between CYP2C9 rs2860905 Polymorphism and Atrial Fibrillation on Ischemic Stroke in Taiwan Biobank Participants | Full Text | References | PDF (317.9 KB) | EPUB
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Article
Wuzhi Capsule Dosage Affects Tacrolimus Elimination in Adult Kidney Transplant Recipients, as Determined by a Population Pharmacokinetics Analysis
Lizhi Chen, Yunyun Yang, Xuebin Wang, Chenyu Wang, Weiwei Lin, Zheng Jiao & Zhuo Wang
Pages: 1093-1106
Published online: 03 Sep 2021
AbstractforWuzhi Capsule Dosage Affects Tacrolimus Elimination in Adult Kidney Transplant Recipients, as Determined by a Population Pharmacokinetics Analysis | Full Text | References | PDF (1.6 MB) | EPUB
  • 123 Views
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Article
Incidence and Risk Factors of Lower-Extremity Deep Vein Thrombosis After Thrombolysis Among Patients with Acute Ischemic Stroke
Zhuo Liu, Dandan Liu, Zhen-Ni Guo, Hang Jin, Tong Sun, Chunping Ni & Xiuli Yan
Pages: 1107-1114
Published online: 04 Sep 2021
AbstractforIncidence and Risk Factors of Lower-Extremity Deep Vein Thrombosis After Thrombolysis Among Patients with Acute Ischemic Stroke | Full Text | References | PDF (721 KB) | EPUB
  • 192 Views
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Article
Smoking, Hypertension, and GG Genotype of the IL-6 rs1800796 Polymorphism are Independent Risk Factors for Abdominal Aortic Aneurysm in Han Population
Yuchao Zhang, Gang Xu & Ping Wang
Pages: 1115-1121
Published online: 07 Sep 2021
AbstractforSmoking, Hypertension, and GG Genotype of the IL-6 rs1800796 Polymorphism are Independent Risk Factors for Abdominal Aortic Aneurysm in Han Population | Full Text | References | PDF (325.2 KB) | EPUB
  • 136 Views
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Article
Search for Possible Associations of FTO Gene Polymorphic Variants with Metabolic Syndrome, Obesity and Body Mass Index in Schizophrenia Patients
Anastasiia S Boiko, Ivan V Pozhidaev, Diana Z Paderina, Anna V Bocharova, Irina A Mednova, Olga Yu Fedorenko, Elena G Kornetova, Anton J M Loonen, Arkadiy V Semke, Nikolay A Bokhan & Svetlana A Ivanova
Pages: 1123-1131
Published online: 07 Sep 2021
AbstractforSearch for Possible Associations of FTO Gene Polymorphic Variants with Metabolic Syndrome, Obesity and Body Mass Index in Schizophrenia Patients | Full Text | References | PDF (1,010.9 KB) | EPUB
  • 200 Views
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Article
Gephyrin and CYP2C9 Genetic Polymorphisms in Patients with Pharmacoresistant Epilepsy
Hamdy N El-Tallawy, Sawsan Abuhamdah, Ahmed Y Nassar, Wafaa M A Farghaly, Tahia H Saleem, Sara A Atta, Ayat A Sayed, Amal M Tohamy & Mohammed H Hassan
Pages: 1133-1140
Published online: 09 Sep 2021
AbstractforGephyrin and CYP2C9 Genetic Polymorphisms in Patients with Pharmacoresistant Epilepsy | Full Text | References | PDF (1.7 MB) | EPUB
  • 134 Views
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Article
Genetic Polymorphism of GABRG2 rs211037 is Associated with Drug Response and Adverse Drug Reactions to Valproic Acid in Chinese Southern Children with Epilepsy
Jieluan Lu, Hanbing Xia, Wenzhou Li, Xianhuan Shen, Huijuan Guo, Jianping Zhang & Xiaomei Fan
Pages: 1141-1150
Published online: 17 Nov 2022
AbstractforGenetic Polymorphism of GABRG2 rs211037 is Associated with Drug Response and Adverse Drug Reactions to Valproic Acid in Chinese Southern Children with Epilepsy | Full Text | References | PDF (1.8 MB) | EPUB
  • 184 Views
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Article
DZIP1 Expression as a Prognostic Marker in Gastric Cancer: A Bioinformatics-Based Analysis
Yuan-Jie Liu, Jie-Pin Li, Shu-Hong Zeng, Mei Han, Shen-Lin Liu & Xi Zou
Pages: 1151-1168
Published online: 16 Sep 2021
AbstractforDZIP1 Expression as a Prognostic Marker in Gastric Cancer: A Bioinformatics-Based Analysis | Full Text | References | PDF (19 MB) | EPUB
  • 141 Views
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Article
Metabolic Processes are Potential Biological Processes Distinguishing Nonischemic Dilated Cardiomyopathy from Ischemic Cardiomyopathy: A Clue from Serum Proteomics
Guangyong Huang, Zhiqi Huang, Yunling Peng, Yuehai Wang, Weitao Liu, Yuzeng Xue & Wenbo Yang
Pages: 1169-1184
Published online: 16 Sep 2021
AbstractforMetabolic Processes are Potential Biological Processes Distinguishing Nonischemic Dilated Cardiomyopathy from Ischemic Cardiomyopathy: A Clue from Serum Proteomics | Full Text | References | PDF (15.3 MB) | EPUB
  • 182 Views
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Article
The Effects of Gene Variations of GABRA2, GABRB1, GABRG2, GAD1 and SLC1A3 on Patients with Propofol During Anesthesia Induction
Lingyi Zhang, Zhuoling Zheng, Wudi Ma, Shuyu Zhang, Faling Xue, Haini Wang, Yongqi He, Fang Ye, Shouning Zhou, Yongzi Wen, Xiaoyan Li, Wenqi Huang, Min Huang, Jiali Li & Zhongxing Wang
Pages: 1185-1192
Published online: 17 Nov 2022
AbstractforThe Effects of Gene Variations of GABRA2, GABRB1, GABRG2, GAD1 and SLC1A3 on Patients with Propofol During Anesthesia Induction | Full Text | References | PDF (1.7 MB) | EPUB
  • 213 Views
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Article
The Effects of WISP1 Polymorphisms on the Prognosis of Lung Cancer Patients with Platinum-Based Chemotherapy
Jia He, Zhan Wang, Ying Wang, Ting Zou, Xiang-Ping Li, Lei Cao & Juan Chen
Pages: 1193-1203
Published online: 18 Sep 2021
AbstractforThe Effects of WISP1 Polymorphisms on the Prognosis of Lung Cancer Patients with Platinum-Based Chemotherapy | Full Text | References | PDF (1.8 MB) | EPUB
  • 103 Views
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Article
Associations of GWAS-Identified Risk Loci with Progression, Efficacy and Toxicity of Radiotherapy of Head and Neck Squamous Cell Carcinoma Treated with Radiotherapy
Qinghuan Li, Yi Liang, Zeng Liu & Chuanyun Yu
Pages: 1205-1210
Published online: 17 Nov 2022
AbstractforAssociations of GWAS-Identified Risk Loci with Progression, Efficacy and Toxicity of Radiotherapy of Head and Neck Squamous Cell Carcinoma Treated with Radiotherapy | Full Text | References | PDF (308.9 KB) | EPUB
  • 125 Views
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Article
Associations Between Genetically Predicted Plasma N-Glycans and Prostate Cancer Risk: Analysis of Over 140,000 European Descendants
Duo Liu, Jingjing Zhu, Tianying Zhao, Sodbo Sharapov, Evgeny Tiys & Lang Wu
Pages: 1211-1220
Published online: 22 Sep 2021
AbstractforAssociations Between Genetically Predicted Plasma N-Glycans and Prostate Cancer Risk: Analysis of Over 140,000 European Descendants | Full Text | References | PDF (502.2 KB) | EPUB
  • 120 Views
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Article
Influential Factors and Efficacy Analysis of Tacrolimus Concentration After Allogeneic Hematopoietic Stem Cell Transplantation in Children with β-Thalassemia Major
Chengxin Li, Jiejiu Lu, Siru Zhou, Yinyi Wei, Chunle Lv, Taotao Liu, Yun Wu, Dongni Wu, Jianying Qi & Rongda Cai
Pages: 1221-1237
Published online: 24 Sep 2021
AbstractforInfluential Factors and Efficacy Analysis of Tacrolimus Concentration After Allogeneic Hematopoietic Stem Cell Transplantation in Children with β-Thalassemia Major | Full Text | References | PDF (8 MB) | EPUB
  • 116 Views
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Article
RETRACTED ARTICLE: FTO Gene Polymorphisms Contribute to the Predisposition and Radiotherapy Efficiency of Nasopharyngeal Carcinoma
Feng Xiao & Jianrong Zhou
Pages: 1239-1245
Published online: 28 Sep 2021
AbstractforRETRACTED ARTICLE: FTO Gene Polymorphisms Contribute to the Predisposition and Radiotherapy Efficiency of Nasopharyngeal Carcinoma | PDF (845.9 KB)
  • 14 Views
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Article
The Clinical Significance of miR-21 in Guiding Chemotherapy for Patients with Osteosarcoma
Li-Zhi Li, Zhuang-Zhuang Wu & Zhi Lv
Pages: 1247-1261
Published online: 29 Sep 2021
AbstractforThe Clinical Significance of miR-21 in Guiding Chemotherapy for Patients with Osteosarcoma | Full Text | References | PDF (7.7 MB) | EPUB
  • 89 Views
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Article
miR-7, miR-10a and miR-143 Expression May Predict Response to Bevacizumab Plus Chemotherapy in Patients with Metastatic Colorectal Cancer
Alicia Romero-Lorca, Apolonia Novillo, María Gaibar, María Fuencisla Gilsanz, Miguel Galán, Laura Beltrán, Beatriz Antón, Diego Malón, Amalia Moreno & Ana Fernández-Santander
Pages: 1263-1273
Published online: 17 Nov 2022
AbstractformiR-7, miR-10a and miR-143 Expression May Predict Response to Bevacizumab Plus Chemotherapy in Patients with Metastatic Colorectal Cancer | Full Text | References | PDF (2.9 MB) | EPUB
  • 118 Views
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Article
Analysis of Very Important Pharmacogenomics Variants in the Chinese Lahu Population
Yujing Cheng, Qi Li, Xin Yang, Heng Ding, Wanlu Chen, Run Dai & Chan Zhang
Pages: 1275-1289
Published online: 01 Oct 2021
AbstractforAnalysis of Very Important Pharmacogenomics Variants in the Chinese Lahu Population | Full Text | References | PDF (2.5 MB) | EPUB
  • 137 Views
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Article
Nuclear Pore Glycoprotein 62 Genetic Variant rs9523 is Associated with Clinical Outcomes of Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors in Lung Adenocarcinoma Patients
Ji Eun Park, Mi Jeong Hong, Shin Yup Lee, Jang Hyuck Lee, Jin Eun Choi, Hyo-Gyoung Kang, Sook Kyung Do, Ji Yun Jeong, Kyung Min Shin, Won Kee Lee, Sun Ha Choi, Yong Hoon Lee, Hye won Seo, Seung Soo Yoo, Jaehee Lee, Seung Ick Cha, Chang Ho Kim & Jae Yong Park
Pages: 1291-1302
Published online: 01 Oct 2021
AbstractforNuclear Pore Glycoprotein 62 Genetic Variant rs9523 is Associated with Clinical Outcomes of Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors in Lung Adenocarcinoma Patients | Full Text | References | PDF (3.6 MB) | EPUB
  • 107 Views
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Article
NUDT15 c.415C>T Polymorphism Predicts 6-MP Induced Early Myelotoxicity in Patients with Acute Lymphoblastic Leukemia Undergoing Maintenance Therapy
Aswin Anand Pai, Ajith Mohan, Esther Sathya Bama Benjamin, Raveen Stephen Stallon Illangeswaran, Infencia Xavier Raj, Nancy Beryl Janet, Arun Kumar Arunachalam, M L Kavitha, Uday Kulkarni, Anup J Devasia, N A Fouzia, Aby Abraham, Alok Srivastava, Biju George, Vikram Mathews, Anu Korula & Poonkuzhali Balasubramanian
Pages: 1303-1313
Published online: 17 Nov 2022
AbstractforNUDT15 c.415C>T Polymorphism Predicts 6-MP Induced Early Myelotoxicity in Patients with Acute Lymphoblastic Leukemia Undergoing Maintenance Therapy | Full Text | References | PDF (2.9 MB) | EPUB
  • 142 Views
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Article
Pharmacokinetics of Tenofovir Alafenamide Fumarate and Tenofovir in the Chinese People: Effects of Non-Genetic Factors and Genetic Variations
Xue Li, Xin-Yi Tan, Xue-Jun Cui, Ming Yang, Chao Chen & Xiao-Yun Chen
Pages: 1315-1329
Published online: 14 Oct 2021
AbstractforPharmacokinetics of Tenofovir Alafenamide Fumarate and Tenofovir in the Chinese People: Effects of Non-Genetic Factors and Genetic Variations | Full Text | References | PDF (2.7 MB) | EPUB
  • 320 Views
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Article
H/ACA snoRNP Gene Family as Diagnostic and Prognostic Biomarkers for Hepatocellular Carcinoma
Mi Zhang, Wei Zhao, Shanshan Liu, Haichuan Liu, Liang Liu, Qiling Peng, Chengyou Du & Ning Jiang
Pages: 1331-1345
Published online: 17 Nov 2022
AbstractforH/ACA snoRNP Gene Family as Diagnostic and Prognostic Biomarkers for Hepatocellular Carcinoma | Full Text | References | PDF (13.6 MB) | EPUB
  • 151 Views
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Article
Pattern Recognition Molecules of Lectin Complement Pathway in Ischemic Stroke
Gohar Tsakanova, Ani Stepanyan, Rudi Steffensen, Armine Soghoyan, Jens Christian Jensenius & Arsen Arakelyan
Pages: 1347-1368
Published online: 21 Oct 2021
AbstractforPattern Recognition Molecules of Lectin Complement Pathway in Ischemic Stroke | Full Text | References | PDF (9.6 MB) | EPUB
  • 99 Views
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Article
Exploring the Epigenetic Regulatory Role of m6A-Associated SNPs in Type 2 Diabetes Pathogenesis
Miao Chen, Weimin Lin, Jianru Yi & Zhihe Zhao
Pages: 1369-1378
Published online: 27 Oct 2021
AbstractforExploring the Epigenetic Regulatory Role of m6A-Associated SNPs in Type 2 Diabetes Pathogenesis | Full Text | References | PDF (4.2 MB) | EPUB
  • 137 Views
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Article
Analysis of Combined Effect of CYP2C19 Genetic Polymorphism and Proton Pump Inhibitors Coadministration on Trough Concentration of Voriconazole
Magesa Mafuru, Sanlan Wu, Henry Mayala, Zaituni Msengwa, Amani Phillip & Charles Mgone
Pages: 1379-1389
Published online: 02 Nov 2021
AbstractforAnalysis of Combined Effect of CYP2C19 Genetic Polymorphism and Proton Pump Inhibitors Coadministration on Trough Concentration of Voriconazole | Full Text | References | PDF (2.6 MB) | EPUB
  • 125 Views
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Article
Variation of Genomic Sites Associated with Severe Covid-19 Across Populations: Global and National Patterns
Oleg Balanovsky, Valeria Petrushenko, Karin Mirzaev, Sherzod Abdullaev, Igor Gorin, Denis Chernevskiy, Anastasiya Agdzhoyan, Elena Balanovska, Alexander Kryukov, Ilyas Temirbulatov & Dmitriy Sychev
Pages: 1391-1402
Published online: 17 Nov 2022
AbstractforVariation of Genomic Sites Associated with Severe Covid-19 Across Populations: Global and National Patterns | Full Text | References | PDF (9.8 MB) | EPUB
  • 138 Views
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Article
The Relevance of Regenerating Gene 1a Polymorphisms to Radiation Sensitivity and Survival of Nasopharyngeal Carcinoma Receiving Radiotherapy in a Southern Chinese Population
Hai-Jie Xing, Xiang-Dong Chen, Hong-Xia Sun, Yao-Zhang Dai, Yao-Feng Han, Hai-Bo Chen & Feng Liu
Pages: 1403-1413
Published online: 17 Nov 2022
AbstractforThe Relevance of Regenerating Gene 1a Polymorphisms to Radiation Sensitivity and Survival of Nasopharyngeal Carcinoma Receiving Radiotherapy in a Southern Chinese Population | Full Text | References | PDF (2.5 MB) | EPUB
  • 110 Views
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Article
Identification of Two Novel DNAAF2 Variants in Two Consanguineous Families with Primary Ciliary Dyskinesia
Chenyang Lu, Danhui Yang, Cheng Lei, Rongchun Wang, Ting Guo & Hong Luo
Pages: 1415-1423
Published online: 10 Nov 2021
AbstractforIdentification of Two Novel DNAAF2 Variants in Two Consanguineous Families with Primary Ciliary Dyskinesia | Full Text | References | PDF (4.8 MB) | EPUB
  • 121 Views
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Article
ARNTL2 is a Prognostic Biomarker and Correlates with Immune Cell Infiltration in Triple-Negative Breast Cancer
Xiaoyu Wang, Yan Li, Jianchang Fu, Kewen Zhou & Tinghuai Wang
Pages: 1425-1440
Published online: 10 Nov 2021
AbstractforARNTL2 is a Prognostic Biomarker and Correlates with Immune Cell Infiltration in Triple-Negative Breast Cancer | Full Text | References | PDF (9.8 MB) | EPUB
  • 139 Views
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Review

Review Article
Pharmacogenomics and Personalized Medicine in Type 2 Diabetes Mellitus: Potential Implications for Clinical Practice
Poongothai Venkatachalapathy, Sruthi Padhilahouse, Mohan Sellappan, Tharunika Subramanian, Shilia Jacob Kurian, Sonal Sekhar Miraj, Mahadev Rao, Ashwin Ashok Raut, Rupinder Kaur Kanwar, Jitendra Singh, Sagar Khadanga, Sukumar Mondithoka & Murali Munisamy
Pages: 1441-1455
Published online: 13 Nov 2021
AbstractforPharmacogenomics and Personalized Medicine in Type 2 Diabetes Mellitus: Potential Implications for Clinical Practice | Full Text | References | PDF (1,006.5 KB) | EPUB
  • 918 Views
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Case Report

Case Report
The Help of HPV Integration Testing to Avoid the Misdiagnosis of a Patient with Stage Ia1 Cervical Cancer: A Case Report and Literature Review
Jialu Li, Xiaoli Zhang, Pengpeng Wang & Weiping Li
Pages: 1457-1461
Published online: 18 Nov 2021
AbstractforThe Help of HPV Integration Testing to Avoid the Misdiagnosis of a Patient with Stage Ia1 Cervical Cancer: A Case Report and Literature Review | Full Text | References | PDF (229.9 KB) | EPUB
  • 149 Views
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Original Research

Article
Genetic Polymorphisms Affecting Tacrolimus Metabolism and the Relationship to Post-Transplant Outcomes in Kidney Transplant Recipients
Fang Cheng, Qiang Li, Jinglin Wang, Min Hu, Fang Zeng, Zhendi Wang & Yu Zhang
Pages: 1463-1474
Published online: 19 Nov 2021
AbstractforGenetic Polymorphisms Affecting Tacrolimus Metabolism and the Relationship to Post-Transplant Outcomes in Kidney Transplant Recipients | Full Text | References | PDF (3.1 MB) | EPUB
  • 200 Views
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Article
Association Between the Interferon-γ +874 T/A Polymorphism and the Risk and Clinical Manifestations of Systemic Lupus Erythematosus: A Preliminary Study
Shanshan Liu, Ju Li, Yongsheng Li, Yan Liu, Kai Wang & Wenyou Pan
Pages: 1475-1482
Published online: 17 Nov 2022
AbstractforAssociation Between the Interferon-γ +874 T/A Polymorphism and the Risk and Clinical Manifestations of Systemic Lupus Erythematosus: A Preliminary Study | Full Text | References | PDF (355.9 KB) | EPUB
  • 118 Views
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Article
Prognostic Value of LHFPL Tetraspan Subfamily Member 6 (LHFPL6) in Gastric Cancer: A Study Based on Bioinformatics Analysis and Experimental Validation
Yuan-Jie Liu, Sheng-Yan Yin, Shu-Hong Zeng, Yi-Dou Hu, Meng-Qi Wang, Pan Huang & Jie-Pin Li
Pages: 1483-1504
Published online: 17 Nov 2022
AbstractforPrognostic Value of LHFPL Tetraspan Subfamily Member 6 (LHFPL6) in Gastric Cancer: A Study Based on Bioinformatics Analysis and Experimental Validation | Full Text | References | PDF (22.1 MB) | EPUB
  • 131 Views
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Article
A Missense Variant in Granulysin is Associated with the Efficacy of Pegylated-Interferon-Alpha Therapy in Chinese Patients with HBeAg-Positive Chronic Hepatitis B
Jing Li, Haitao Chen, Jiaxuan Chen, Bin Zhou, Jinlin Hou & De-Ke Jiang
Pages: 1505-1515
Published online: 23 Nov 2021
AbstractforA Missense Variant in Granulysin is Associated with the Efficacy of Pegylated-Interferon-Alpha Therapy in Chinese Patients with HBeAg-Positive Chronic Hepatitis B | Full Text | References | PDF (4.6 MB) | EPUB
  • 98 Views
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Review

Review Article
Clinical Development of AKT Inhibitors and Associated Predictive Biomarkers to Guide Patient Treatment in Cancer Medicine
Niamh Coleman, Justin T Moyers, Alice Harbery, Igor Vivanco & Timothy A Yap
Pages: 1517-1535
Published online: 25 Nov 2021
AbstractforClinical Development of AKT Inhibitors and Associated Predictive Biomarkers to Guide Patient Treatment in Cancer Medicine | Full Text | References | PDF (2.3 MB) | EPUB
  • 282 Views
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Original Research

Article
Genetic Polymorphism of Drug Metabolic Gene CYPs, VKORC1, NAT2, DPYD and CHST3 of Five Ethnic Minorities in Heilongjiang Province, Northeast China
Tingting Zhang, Qiuyan Li, Bonan Dong, Xiao Liang, Mansha Jia, Jing Bai, Jingcui Yu & Songbin Fu
Pages: 1537-1547
Published online: 30 Nov 2021
AbstractforGenetic Polymorphism of Drug Metabolic Gene CYPs, VKORC1, NAT2, DPYD and CHST3 of Five Ethnic Minorities in Heilongjiang Province, Northeast China | Full Text | References | PDF (613.5 KB) | EPUB
  • 153 Views
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Article
Development and Validation of a Prognostic N6-Methyladenosine-Related Immune Gene Signature for Lung Adenocarcinoma
Lemeng Zhang, Yongzhong Luo, Tianli Cheng, Jianhua Chen, Hua Yang, Xiaoping Wen, Zhou Jiang, Haitao Li & Changqie Pan
Pages: 1549-1563
Published online: 30 Nov 2021
AbstractforDevelopment and Validation of a Prognostic N6-Methyladenosine-Related Immune Gene Signature for Lung Adenocarcinoma | Full Text | References | PDF (10.3 MB) | EPUB
  • 118 Views
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Article
Genetic Variant of PP2A Subunit Gene Confers an Increased Risk of Primary Liver Cancer in Chinese
Youxin Wang, Qiuyue Huang, Xinglei Huang, Huiliu Zhao, Bin Guan, Kechen Ban, Xuefeng Zhu, Zhixing Ma, Yanmei Tang, Zhaohui Su & Qingqing Nong
Pages: 1565-1574
Published online: 17 Nov 2022
AbstractforGenetic Variant of PP2A Subunit Gene Confers an Increased Risk of Primary Liver Cancer in Chinese | Full Text | References | PDF (1.9 MB) | EPUB
  • 131 Views
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Article
MicroRNAs as Novel Biomarkers for P2Y12 – Inhibitors Resistance Prediction
Eric Rytkin, Karin Mirzaev, Irina Bure, Kristina Akmalova, Sherzod Abdullaev, Anastasiia Kachanova, Valery Smirnov, Elena Grishina, Natalia Lyakhova, Elena Aleshkovich, Anna Saribekian, Denis Andreev, Alexey Shabunin & Dmitry Sychev
Pages: 1575-1582
Published online: 02 Dec 2021
AbstractforMicroRNAs as Novel Biomarkers for P2Y12 – Inhibitors Resistance Prediction | Full Text | References | PDF (1.8 MB) | EPUB
  • 112 Views
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Case Report

Case Report
Identification of a Novel VPS13B Mutation in a Chinese Patient with Cohen Syndrome by Whole-Exome Sequencing
Xiaoyun Hu, Tao Huang, Yun Liu, Lina Zhang, Li Zhu, Xiaohong Peng & Sufang Zhang
Pages: 1583-1589
Published online: 04 Dec 2021
AbstractforIdentification of a Novel VPS13B Mutation in a Chinese Patient with Cohen Syndrome by Whole-Exome Sequencing | Full Text | References | PDF (1.5 MB) | EPUB
  • 101 Views
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Original Research

Article
Apolipoprotein E Gene Polymorphism and Coronary Artery Disease Risk Among Patients in Northwest China
Wenbing Ma, Xiaodong Ren, Liting Zhang, Haiyan Dong, Xiaoyun Lu & Weiyi Feng
Pages: 1591-1599
Published online: 07 Dec 2021
AbstractforApolipoprotein E Gene Polymorphism and Coronary Artery Disease Risk Among Patients in Northwest China | Full Text | References | PDF (410.9 KB) | EPUB
  • 173 Views
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Retraction

Retraction
FTO Gene Polymorphisms Contribute to the Predisposition and Radiotherapy Efficiency of Nasopharyngeal Carcinoma [Retraction]
Pages: 1601-1602
Published online: 07 Dec 2021
CitationforFTO Gene Polymorphisms Contribute to the Predisposition and Radiotherapy Efficiency of Nasopharyngeal Carcinoma [Retraction] | Full Text | PDF (138.2 KB) | EPUB
  • 75 Views
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Review

Review Article
Ethnic Diversity of DPD Activity and the DPYD Gene: Review of the Literature
Cassandra White, Rodney J Scott, Christine Paul, Andrew Ziolkowski, David Mossman & Stephen Ackland
Pages: 1603-1617
Published online: 17 Nov 2022
AbstractforEthnic Diversity of DPD Activity and the DPYD Gene: Review of the Literature | Full Text | References | PDF (1 MB) | EPUB
  • 464 Views
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Original Research

Article
The Landscape of Clinical Implementation of Pharmacogenetic Testing in Central China: A Single-Center Study
Jingmin Zhang, Guangzhao Qi, Chao Han, Yubing Zhou, Yongjie Yang, Xinru Wang, Suna Liu & Xiaojian Zhang
Pages: 1619-1628
Published online: 17 Nov 2022
AbstractforThe Landscape of Clinical Implementation of Pharmacogenetic Testing in Central China: A Single-Center Study | Full Text | References | PDF (4.8 MB) | EPUB
  • 102 Views
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Article
Interleukin-16 rs4072111 Polymorphism is Associated with the Risk of Peri-Implantitis in the Chinese Population
Zongfei Chen & Guanhua Chen
Pages: 1629-1635
Published online: 17 Nov 2022
AbstractforInterleukin-16 rs4072111 Polymorphism is Associated with the Risk of Peri-Implantitis in the Chinese Population | Full Text | References | PDF (328.2 KB) | EPUB
  • 120 Views
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Article
RF1 Gene Mutation in Familial Hemophagocytic Lymphohistiocytosis 2: A Family Report and Literature Review
Yuan Shi, Zhidong Qiao, Xiaoduo Bi, Chenxin Zhang, Junxian Fu, Yuexin Jia & Guanglu Yang
Pages: 1637-1645
Published online: 17 Nov 2022
AbstractforRF1 Gene Mutation in Familial Hemophagocytic Lymphohistiocytosis 2: A Family Report and Literature Review | Full Text | References | PDF (2.1 MB) | EPUB
  • 146 Views
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Article
Genetic Polymorphisms of Very Important Pharmacogene Variants in the Blang Population from Yunnan Province in China
Yuliang Wang, Linna Peng, Hongyan Lu, Zhanhao Zhang, Shishi Xing, Dandan Li, Chunjuan He, Tianbo Jin & Li Wang
Pages: 1647-1660
Published online: 17 Nov 2022
AbstractforGenetic Polymorphisms of Very Important Pharmacogene Variants in the Blang Population from Yunnan Province in China | Full Text | References | PDF (1.7 MB) | EPUB
  • 106 Views
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Article
Combined GSTT1 Null, GSTM1 Null and XPD Lys/Lys Genetic Polymorphisms and Their Association with Increased Risk of Chronic Myeloid Leukemia
Ezeldine K Abdalhabib, Denise E Jackson, Badr Alzahrani, Elyasa M Elfaki, Alneil Hamza, Fehaid Alanazi, Elryah I Ali, Abdulrahman Algarni, Ibrahim Khider Ibrahim & Muhammad Saboor
Pages: 1661-1667
Published online: 17 Nov 2022
AbstractforCombined GSTT1 Null, GSTM1 Null and XPD Lys/Lys Genetic Polymorphisms and Their Association with Increased Risk of Chronic Myeloid Leukemia | Full Text | References | PDF (329.1 KB) | EPUB
  • 142 Views
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PFN1 Gene Polymorphisms and the Bone Mineral Density Response to Alendronate Therapy in Postmenopausal Chinese Women with Low Bone Mass
Jiao Zhao, Li Liu, Shanshan Lv, Chun Wang, Hua Yue & Zhenlin Zhang
Pages: 1669-1678
Published online: 17 Nov 2022
AbstractforPFN1 Gene Polymorphisms and the Bone Mineral Density Response to Alendronate Therapy in Postmenopausal Chinese Women with Low Bone Mass | Full Text | References | PDF (955.4 KB) | EPUB
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Isotretinoin Induced Hyperlipidemia and Impact of Leptin Gene rs 7799039 Polymorphism in Safety of Acne Patients
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Pages: 1679-1687
Published online: 17 Nov 2022
AbstractforIsotretinoin Induced Hyperlipidemia and Impact of Leptin Gene rs 7799039 Polymorphism in Safety of Acne Patients | Full Text | References | PDF (382.5 KB) | EPUB
  • 188 Views
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Review

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Fragile X Premutation: Medications, Therapy and Lifestyle Advice
Deepika Kour Sodhi & Randi Hagerman
Pages: 1689-1699
Published online: 17 Nov 2022
AbstractforFragile X Premutation: Medications, Therapy and Lifestyle Advice | Full Text | References | PDF (462 KB) | EPUB
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Original Research

Article
ADAMTS8 Expression is a Potential Prognostic Biomarker for Postoperative Metastasis in Lymph Node-Negative Early-Stage Invasive Breast Carcinoma Patients
Yao Li, Xin Yang, Jie Sun, Yangyang Zhao, Qi Zhou & Bin Hua
Pages: 1701-1713
Published online: 17 Nov 2022
AbstractforADAMTS8 Expression is a Potential Prognostic Biomarker for Postoperative Metastasis in Lymph Node-Negative Early-Stage Invasive Breast Carcinoma Patients | Full Text | References | PDF (7.6 MB) | EPUB
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Corrigendum

Correction
The EGFR Polymorphism Increased the Risk of Hepatocellular Carcinoma Through the miR-3196-Dependent Approach in Chinese Han Population [Corrigendum]
Pages: 1715-1716
Published online: 30 Dec 2021
CitationforThe EGFR Polymorphism Increased the Risk of Hepatocellular Carcinoma Through the miR-3196-Dependent Approach in Chinese Han Population [Corrigendum] | Full Text | PDF (136.1 KB) | EPUB
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Systematic Pan-Cancer Analysis of KIF23 and a Prediction Model Based on KIF23 in Clear Cell Renal Cell Carcinoma (ccRCC)
Xiaojie Bai, Yuanfei Cao, Xin Yan, Kurerban Tuoheti, Guowei Du, Zhao Chen, Huahui Wu, Linfa Guo & Tongzu Liu
Pages: 1717-1729
Published online: 17 Nov 2022
AbstractforSystematic Pan-Cancer Analysis of KIF23 and a Prediction Model Based on KIF23 in Clear Cell Renal Cell Carcinoma (ccRCC) | Full Text | References | PDF (10.5 MB) | EPUB
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Relationship Between KCNQ1 Polymorphism and Type 2 Diabetes Risk in Northwestern China
Jing Xu, Wei Zhang, Wei Song, Jiaqi Cui, Yanni Tian, Huan Chen, Pan Huang, Shujun Yang, Lu Wang, Xin He, Lin Wang, Bingyin Shi & Wei Cui
Pages: 1731-1751
Published online: 31 Dec 2021
AbstractforRelationship Between KCNQ1 Polymorphism and Type 2 Diabetes Risk in Northwestern China | Full Text | References | PDF (6.9 MB) | EPUB
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