The Landscape of Clinical Implementation of Pharmacogenetic Testing in Central China: A Single-Center Study

Figures & data

Table 1 Characterization of 47,265 PGx Testing

Number of PGx Testing
Year	Outpatient	Inpatient	Male	Female	CYP2C19 (*2, *3)	MTHFR C677T	CYP2C9 (*2, *3) and VKORC1 (G-1639A)	ALDH Glu504Lys	PGx	Department
2013	11	980	587	404	720	165	105	1	991	35
2014	304	6873	4167	3010	3527	2976	592	82	7177	63
2015	349	7977	4735	3591	3730	3690	826	80	8326	55
2016	296	8823	5381	3738	4603	3822	630	64	9119	52
2017	528	9731	5767	4492	5377	4217	563	102	10,259	52
2018	719	10,674	6268	5125	5791	4863	638	101	11,393	39
2013–2018	2207	45,058	26,905	20,360	23,748	19,733	3354	430	47,265	84

Notes: CYP2C19 *2, NG_008384.3:g.24179G>A, dbSNP:rs4244285; CYP2C19 *3, NG_008384.3:g.22973G>A, p.W212X, dbSNP:rs4986893; CYP2C9 *2, NG_008385.2:g.9133C>T, p.R144C, dbSNP:rs1799853; CYP2C9 *3, NG_008385.2:g.48139A>C, p.I359L, dbSNP:rs1057910.

Abbreviations: PGx, pharmacogenetics; CYP2C19, cytochrome P450 2C19; MTHFR, methylene tetrahydrofolate reductase; CYP2C9, cytochrome P450 2C9; VKORC1, vitamin K epoxide reductase complex subunit 1; ALDH, aldehyde dehydrogenase.

Figure 1 Age distribution of 47,265 pharmacogenetic testing results. Age distribution in (A) kernel density estimation and (B) histogram.

Table 2 The Detection Rate of PGx Testing in the Inpatient Departments

Year	Top Five Departments	Number of Tested Patients	Number of Inpatients	Rate (%)
2013	Cardiology	266	2724	9.8
	Psychiatry	183	608	30.1
	ICU	155	193	80.3
	Cardiac Surgery	110	570	19.3
	Intervention	90	712	12.6
2014	Psychiatry	1753	3490	50.2
	Cardiology	1583	16,852	9.4
	ICU	973	2515	38.7
	Intervention	772	3499	22.1
	Cardiac Surgery	720	6208	11.6
2015	Cardiology	1664	18,535	9.0
	Psychiatry	1445	3435	42.1
	Endovascular Surgery	1331	3422	38.9
	ICU	1040	2622	39.7
	Intervention	1033	7097	14.6
2016	Cardiology	2721	21,169	12.9
	Psychiatry	1655	3496	47.3
	Endovascular Surgery	978	4346	22.5
	Cardiac Surgery	901	4696	19.2
	Intervention	864	8372	10.3
2017	Cardiology	3165	26,274	12.0
	Psychiatry	1781	3677	48.4
	ICU	1079	4242	25.4
	Endovascular Surgery	951	5294	18.0
	Cardiac Surgery	919	3692	24.9
2018	Cardiology	2940	30,299	9.7
	Intervention	1937	6718	28.8
	Psychiatry	1873	4041	46.3
	Cardiac Surgery	1010	6526	15.5
	ICU	1005	4600	21.8

Figure 2 Departments distribution of 47,265 pharmacogenetic testing from 2013 to 2018.

Figure 3 Continue.

Figure 3 Departments distribution of annual pharmacogenetic testing results from 2013 to 2018. (A) 2013, (B) 2014, (C) 2015, (D) 2016, (E) 2017, (F) 2018.