Influence of Long Non-Coding RNAs on Human Oocyte Development

Figures & data

Table 1 Up-Regulated lncRNAs That Regulate miRNA in GCs of Patients with PCOS

LncRNA	Regulated miRNA	Functions	Reference
PWRN2	miR-92b-3p	Influence oocyte nuclear maturation in PCOS	[43]
PVT1	miR-17-5p	Regulate the proliferation and the apoptosis of GCs	[44]
ZFAS1	miR-129	Prevent the degradation of HMGB1 and affect the endocrine disorder, proliferation and apoptosis of GCs	[45]
NEAT1	miR-16, miR-483 and miR-324-3p	Promote cell proliferation and inhibit cell apoptosis	[46]
HOTAIRM1	miR-433-5p	Promote PIK3CD expression, thereby regulating the growth and apoptosis of GCs	[47]
PLAC2	miR-19a	Participate in the occurrence of PCOS	[48]
XIST	miR-30c-5p	Inhibit cell proliferation and inducing apoptosis, and is associated with adverse pregnancy outcomes.	[49]
H19	miR-19b	Regulate the proliferation and apoptosis of GCs	[50,51]
CDKN2B-AS1	miR-181a	Affect the proliferation of GCs	[52]

Table 2 LncRNAs in GCs of Patients with PCOS

LncRNA	Up/Down regulation	Functions	Reference
HCG26	Up	Affect cell proliferation and cell cycle progression along with increased aromatase gene (CYP19A1) expression and estradiol production	[54]
BANCR	Up	Promote the expression of pro-apoptotic markers Bax and P53 to inhibit cell proliferation and induce cell apoptosis	[55]
HUPCOS	Up	Induce the excess of androgens in follicular fluid in PCOS patients	[56]
TUG1	Up	Inhibit apoptosis and autophagy of GCs by ERK/MAPK pathway, thus leading to antral follicle increase	[57]
HAS2-AS1	Up	Induce the hypermethylation in the promoter region of TGFBR2 to inhibit TGF-β signaling	[58]
MAP3K13-7:1	Up	Resulted in cell cycle arrest at G0 / G1 phase and inhibit GCs proliferation	[59]
OC1	Up	Affect the cell viability, apoptosis and production of estradiol	[60]

Table 3 LncRNAs in GCs of Patients with Ovarian Insufficiency

LncRNA	Up/Down Regulation	Regulate or Interact with miRNA or protein	Functions	Reference
GULP1-2:1	Down	COL3A1	Affect the proliferation of GCs	[69]
ZNF674-AS1	Down	PCNA and ALDOA	Inhibit glycolysis and proliferation of GCs.	[70]
DLEU1	Up	miR-146b-5p	Promote cell proliferation	[72]
BBOX1-AS1	Up	miR-146b	Affect the cell apoptosis	[73]
HCP5	Down	YB1	Regulate the transcription of MSH5 and DNA damage repair	[74]
PVT1	Down	Foxo3a	Promote the apoptosis of GCs	[75]
DANCR	Down	hNRNPC-p53 interaction	Inhibit cell growth and cause a G1 arrest in the cell cycle	[76]
H19	Down	Let-7	Regulate AMH expression	[77]

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