Patient satisfaction and acceptability of an on-demand and on-prophylaxis device for factor VIII delivery in patients with hemophilia A

Figures & data

Table 1 Demographic data of subjects (N=84)

Variable
Mean age (years)	37.7
Education, n (%)
Middle school	28 (33.3)
High school	44 (52.4)
University	12 (14.3)
Employment status, n (%)
Employed	37 (44)
Casual job	4 (4.8)
Self-employed	13 (15.5)
Unemployed	21 (25.0)
Invalid	1 (1.2)
Student	6 (7.1)
Retired	2 (2.4)
Severity based on Factor VIII level, n (%)
Mild	2 (2.4)
Moderate	10 (11.9)
Severe	72 (85.7)
Regimen, n (%)
On-demand	17 (20.2)
Prophylaxis	67 (79.8)

Figure 1 Percentage of positive responses on TSQM items related to effectiveness, convenience, and overall satisfaction.

Abbreviation: TSQM, Treatment Satisfaction Questionnaire for Medication.

Figure 2 Percentage of patients with positive responses in the HemoPREF questionnaire at V1 (current treatment) and V2 (follow-up with the DCS device).

Note: The improvements from V1 were significant (P<0.01 Wilcoxon signed ranks test) for all questions.
Abbreviation: DCS, dual-chamber syringe.

Figure 3 Percentage of patients with positive responses for the “ease of use” items of the HemoPREF questionnaire at V1 (current treatment) and V2 (follow-up with the DCS device).

Note: *P<0.05 for all between-group comparisons.
Abbreviation: DCS, dual-chamber syringe.

Table 2 Adverse events during the study

Event description	Classification	Intensity
Gastroenteritis	Not serious	Moderate
Anemia	Not serious	Moderate
Cough	Not serious	Mild
High fever (bronchitis)	Not serious	Mild
Esophageal varices	Not serious	Mild
Hyperuricemia	Not serious	Mild
Insomnia and nightmares	Not serious	Moderate
Flu	Not serious	Moderate
Pulpitis	Not serious	Mild
Anal bleeding from hemorrhoids	Not serious	Mild