Potential clinical applications of adult human mesenchymal stem cell (Prochymal®) therapy

Figures & data

Table 1 Surface markers for isolation and characterization of bone marrow mesenchymal stem cells

Positive	Negative
CD13	CD11a,b
CD29	CD14
CD44	CD18 integrin β2
CD49b integrin α2	CD31 PECAN
CD49e integrin α5	CD34
CD54 ICAM1	CD38
CD71 transferrin receptor	CD45
CD73	CD49d integrin α4
CD90	CD50 ICAM3
CD105	CD62E E-selectin
CD106	CD117
CD146	CD133
CD166	CD135
Nestin	HLA-DR
p75 LNGR
HLA-ABC

Figure 1 Key mechanisms involved in beneficial effects of cell therapy using allogeneic mesenchymal stem cells.

Table 2 Clinical evaluation of autologous and allogeneic MSCs*

Trial ID	Sponsor	Condition	Intervention	Phase	Status
NCT00294112	Osiris Therapeutics	Crohn’s disease	Prochymal™ adult human mesenchymal stem cells	II	Completed
NCT00136903	Osiris Therapeutics	Graft versus host disease	Prochymal, 2 and 8 million cells	II	Completed
NCT00543374	Osiris Therapeutics	Crohn’s disease	Adult human mesenchymal stem cells	II	Completed
NCT00826046	Osiris Therapeutics–Quintiles	Graft versus host disease	Prochymal adult human mesenchymal stem cells	NV	NV
NCT00482092	Osiris Therapeutics	Crohn’s disease	Adult human mesenchymal stem cells and placebo	III	Recruiting
NCT00683722	Osiris Therapeutics	Chronic obstructive pulmonary disease, emphysema Chronic bronchitis	Prochymal adult human mesenchymal stem cells and placebo	II	Ongoing
NCT00690066	Osiris Therapeutics and Juvenile Diabetes Research Foundation	Type 1 diabetes mellitus	Prochymal adult human mesenchymal stem cells and placebo	II	Ongoing
NCT00366145	Osiris Therapeutics	Graft versus host disease	Adult human mesenchymal stem cells and placebo	III	Completed
NCT00395200	University of Cambridge	Multiple sclerosis	Adult human mesenchymal stem cells	I and II	NV
NCT01233960	Osiris Therapeutics	Crohn’s disease	Adult human mesenchymal stem cells	III	Recruiting
NCT00759018	Osiris Therapeutics	Graft versus host disease in pediatric patients	Prochymal adult human mesenchymal stem cells		Expanded access
NCT00284986	Osiris Therapeutics	Graft versus host disease	Prochymal adult human mesenchymal stem cells	II	Completed
NCT00877903	Osiris Therapeutics	Myocardial infarction	Prochymal adult human mesenchymal stem cells and placebo	II	Ongoing
NCT00702741	Osiris Therapeutics	Recovery following partial medial meniscectomy	Cultured adult human mesenchymal stem cells	I and II	Ongoing
NCT01087996	NHLBI	Chronic ischemic left ventricular dysfunction	Autologous and allogeneic adult human mesenchymal stem cells	I and II	Recruiting
NCT00587990	NHLBI	Chronic ischemic left ventricular dysfunction	Low and high doses of autologous human mesenchymal stem cells	I and II	Ongoing
NCT00114452	Osiris Therapeutics	Myocardial infarction	Ex vivo cultured adult human mesenchymal stem cells (Provacel™)	I	NV
NCT00768066	University of Miami	Left ventricular dysfunction	Autologous human mesenchymal stem cells, bone marrow cells, and placebo	I and II	Recruiting
NCT01206179	Royan institute	Bone defects	Autologous human mesenchymal stem cells	I	NV
NCT00827398	UMC Utrecht	Graft versus host disease	Mesenchymal stem cells expanded with human plasma and platelet lysate	I and II	Recruiting
NCT00956891	Sun Yat-Sen University	Liver failure	Autologous bone marrow mesenchymal stem cells	I and II	Completed
NCT01318330	HomeoTherapy Co, Ltd	Graft versus host disease	Ex vivo cultured adult human clonal mesenchymal stem cells	I	Recruiting
NCT00885729	Oslo University Hospital	Cartilage defect of the knee	Autologous mesenchymal stem cells	I	Recruiting
NCT00767260	Fuzhou General Hospital	Type 2 diabetes mellitus	Autologous mesenchymal stem cell and bone marrow stem cells	I and II	NV
NCT00749164	Hadassah Medical Organization	Graft versus host disease	Allogeneic mesenchymal stem cells	I and II	Recruiting
NCT00221130	Translational Research Informatics, Japan	Adult periodontitis	Ex vivo cultured mesenchymal stem cells	I and II	Completed
NCT01076920	University Hospital, Toulouse	Chronic myocardial ischemia and left ventricular dysfunction	Autologous mesenchymal stem cells	I and II	Recruiting
NCT00891501	Cairo University	Degenerative arthritis and chondral defects	Autologous mesenchymal stem cells	II and III	Recruiting
NCT00790764	TCA Cellular Therapy	Ischemic heart disease	Bone marrow-derived mononuclear and mesenchymal stem cells	II	Ongoing
NCT01223664	Sun Yat-Sen University	Liver cirrhosis	Allogeneic bone marrow stem cell transplantation	II	Ongoing
NCT01221454	Sun Yat-Sen University	Liver failure	Allogeneic bone marrow stem cell transplantation	II	Ongoing

Note:

* ClinicalTrials.gov.