Evaluating the Frequencies of CNOT3, GRIA1, NFATC2, and PNPLA3 Variant Alleles and Their Association with L-Asparaginase Hypersensitivity in Pediatric Acute Lymphoblastic Leukemia in Addis Ababa, Ethiopia

Figures & data

Table 1 Socio-Demographic Characteristics and Frequency of Asparaginase Hypersensitivity (N = 144)

		n (%)
Child’s sex	Male	94 (65.3)
	Female	50 (34.7)
Child’s age (years)	≤10	122 (84.7)
	>10	22 (15.3)
Hepatosplenomegaly	Hepatomegaly	83 (59.7)
	Splenomegaly	76 (54.7)
Risk group	Standard risk	67 (46.5)
	High risk	77 (53.5)
L-ASP hypersensitivity	Yes	18 (12.5)

Table 2 Genotype and Allele Frequencies of Candidate Gene SNP (N = 160)

	Genotype	Genotype Frequency (%)	Minor Allele Frequency of this Study	dbSNP Minor Allele Frequency (African Population)
GRIA1 rs4958351	GG	108 (67.5)	17.8% (Allele A)	25.2% (Allele A)
	GA	47 (29.4)
	AA	5 (3.1)
CNOT3 rs73062673	TT	140 (87.5)	6.9% (Allele C)	4.6% (Allele C)
	TC	18 (11.3)
	CC	2 (1.3)
NFATC2 rs6021191	AA	142 (88.8)	5.6% (Allele T)	15.2% (Allele T)
	AT	18 (11.3)
PNPLA3 rs738409	CC	111 (69.4)	16.9% (Allele G)	8.9% (Allele G)
	CG	44 (27.5)
	GG	5 (3.1)

Figure 1 Frequency of L-ASP hypersensitivity in relation to the investigated SNPs. For each SNP the reference genotype is depicted in the first bar. (A) GRIA1 rs4958351 (B) CNOT3 rs73062673 (C) NFATC2 rs6021191.