Figures & data
Figure 1 Common osteoporosis risk factors involved in pathways associated with bone formation and osteoporotic fractures.
Note: RA, smoking, glucocorticoids, diabetes mellitus and tumors, the most common risk factors, negatively control the bone organization pathway, resulting in osteoporotic fractures.
Abbreviations: IL, interleukin; M-CSF, macrophage colony stimulating factor; OPG, osteoprotegerin; PPARγ, peroxisome proliferator-activated receptor-γ; PTH, parathyroid hormone; RA, rheumatoid arthritis; RANKL, RANK with its ligand; TNF, tumor necrosis factor; DM, diabetes mellitus; AP2, adipocyte fatty acid binding protein 2; RANK, receptor activator of nuclear factor κ.
Abbreviations: IL, interleukin; M-CSF, macrophage colony stimulating factor; OPG, osteoprotegerin; PPARγ, peroxisome proliferator-activated receptor-γ; PTH, parathyroid hormone; RA, rheumatoid arthritis; RANKL, RANK with its ligand; TNF, tumor necrosis factor; DM, diabetes mellitus; AP2, adipocyte fatty acid binding protein 2; RANK, receptor activator of nuclear factor κ.
![Figure 1 Common osteoporosis risk factors involved in pathways associated with bone formation and osteoporotic fractures.](/cms/asset/08beea25-ef6d-42f0-8ae1-1d4b0f122769/dtcr_a_138000_f0001_c.jpg)
Table 1 Candidate genes associated with osteoporosis